In vitro cancer chemopreventive properties of polysaccharide extract from the brown alga, Sargassum latifolium

Gamal‐Eldeen, Amira M.; Ahmed, Eman F.; Abo-Zeid, Mona A.M.

doi:10.1016/j.fct.2009.03.016

Cited by 102 publications

(39 citation statements)

References 34 publications

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“…In recent years a number of studies reported that seaweed extracts demonstrate strong antioxidant properties (Gamal-Eldeen, Ahmed, Abo-Zeid, 2009). A rich diversity of seaweed exists around the coast of Ireland with over 500 different species documented.…”

Section: Introductionmentioning

confidence: 99%

In vitro and cellular antioxidant activities of seaweed extracts prepared from five brown seaweeds harvested in spring from the west coast of Ireland

et al. 2011

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Section: Introductionmentioning

confidence: 99%

In vitro and cellular antioxidant activities of seaweed extracts prepared from five brown seaweeds harvested in spring from the west coast of Ireland

et al. 2011

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“…During the past decades, polysaccharides have attracted a great deal of attention due to their relatively low toxicity and broad spectrum of therapeutic properties, such as anti-oxidation, anti-tumor, anti-inflammatory and hypoglycemic activities (Chemat, Lagha, AitAmar, Bartels, & Chemat, 2004;Gamal-Eldeen, Ahmed, & Abo-Zeid, 2009;Kanagasabapathy, Chua, Malek, Vikineswary, & Kuppusamy, 2014).…”

Section: Introductionmentioning

confidence: 99%

Bioactivities and extraction optimization of crude polysaccharides from the fruits and leaves of Rubus chingii Hu

Zhang

Jiang

et al. 2015

Carbohydrate Polymers

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“…Polysaccharides isolated from algae are known to exhibit various biological activities such as antitumor, antiviral, anti-inflammatory, antiangiogenic, and immunostimulating. Thus, water-soluble polysaccharides and alginates isolated from algae of the genus Sargassum exhibited antitumor properties [16][17][18][19][20]; sulfonated polysaccharides, antiviral properties [6,[21][22][23].…”

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confidence: 99%

Composition, structural characteristics, and antitumor properties of polysaccharides from the brown algae Dictyopteris polypodioides and Sargassum sp.

et al. 2011

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The polysaccharide compositions of the brown algae Dictyopteris polypodioides and Sargassum sp. from the Mediterranean Sea were determined. The principal polysaccharide of the studied algae (about 12% of the dry alga weight) was alginic acid. The content of water-soluble polysaccharides was low. The amount of fucoidan was less than 1% of the dry alga weight; of neutral polysaccharides, less than 0.25%. The monosaccharide compositions of fucoidans and neutral polysaccharides were investigated. Experiments on soft agar-agar models showed that fucoidans from D. polypodioides and Sargassum sp. exhibited antitumor activity against RPMI-7951 human melanoma cells.The search for biologically active compounds from natural sources is currently of great interest. Polysaccharide-type compounds exhibit a broad spectrum of biological activity and low in vivo toxicity.Brown algae contain compounds with structures that differ from those in red and green algae and terrestrial plants. Mannitol and comparatively low-molecular-weight 1,3;1,6-E-D-glucans (laminarans) act as reserve material in them [1]. Salts of alginic acids (alginates) [2] and complex sulfonated polysaccharides (fucoidans) [3,4] occur in cell walls and intercellular space. The latter exhibit a broad spectrum of biological activity. Structure-activity relationships of the polysaccharides are rather difficult to establish because their structures are heterogeneous, irregular, branched, and highly sulfonated.The goal of the present work was to study the composition, structural characteristics, and antitumor activity of polysaccharides from the Mediterranean algae Dictyopteris polypodioides and Sargassum sp.Alginic acids, neutral polysaccharides, and fucoidans were isolated from these brown algae. Dried and ground algae were treated with EtOH (70%) to remove low-molecular-weight compounds and then extracted with HCl solution. The extract containing water-soluble polysaccharides was concentrated, dialyzed, and placed on a column with the hydrophobic sorbent Polychrom-1. Charged polysaccharides (Dp-F and S-F) were eluted by H 2 O; neutral polysaccharides, by aqueous EtOH (5 and 15%) to afford fractions Dp-5%, Dp-15%, S-5%, and S-15%. Remaining algae were extracted by Na 2 CO 3 solution. The extracts were dialyzed. Alginic acid was precipitated by three times the volume of EtOH (96%) to afford Dp-A and S-A. Fractions Dp-F and S-F contained fucoidans after Polychrom-1 and were separated over a column of Macro-Prep DEAE to afford Dp-F1, Dp-F2, Dp-F3, and Dp-F4 and S-F1, S-F2, S-F3, and S-F4, which were lyophilized to produce alginic acids, neutral polysaccharides, and fucoidans. Table 1 presents the yields of polysaccharides. Table 1 shows that the principal polysaccharide from the studied algae was alginic acid (greater than 12% for both algae), the content of which depended on the species, season, latitude, and ecological habitat [5]. According to the literature, the content of alginic acids in algae of the genus Sargassum varies from 3 to 17% [6,7]. The studied alga coul...

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In vitro cancer chemopreventive properties of polysaccharide extract from the brown alga, Sargassum latifolium

Cited by 102 publications

References 34 publications

In vitro and cellular antioxidant activities of seaweed extracts prepared from five brown seaweeds harvested in spring from the west coast of Ireland

In vitro and cellular antioxidant activities of seaweed extracts prepared from five brown seaweeds harvested in spring from the west coast of Ireland

Bioactivities and extraction optimization of crude polysaccharides from the fruits and leaves of Rubus chingii Hu

Composition, structural characteristics, and antitumor properties of polysaccharides from the brown algae Dictyopteris polypodioides and Sargassum sp.

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