In vitro cellular response and in vivo primary osteointegration of electrochemically modified titanium

Ravanetti, Francesca; Borghetti, Paolo; Angelis, Elena De; Chiesa, Roberto; Martini, Filippo Maria; Gabbi, C.; Cacchioli, Antonio

doi:10.1016/j.actbio.2009.09.022

Cited by 31 publications

(26 citation statements)

References 49 publications

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“…Plasma-sprayed hydroxyapatite (HA) coatings have been widely used to improve bioactivity of Ti materials aiming to enable a quicker healing process after implantation. However, these coatings have shown poor long-term performance associated to the poor adhesion of the coating to the substrate [44,51].…”

Section: Introductionmentioning

confidence: 99%

“…Several surface modification techniques such as Physical Vapor Deposition (PVD), Chemical Vapor Deposition (CVD), ion implantation, and surface oxidation have been applied upon materials in order to avoid surface damage and enhance surface properties of implants [43]. Moreover, chemical (e. g., CVD, sol-gel and alkaline treatments), thermal (e.g., thermal oxidation), and also electrochemical (e.g., electropolishing and anodic oxidation) methods have been induced on Ti-based materials in order to achieve an enhanced biological response and tissue integration [35,[44][45][46][47][48][49][50]. Plasma-sprayed hydroxyapatite (HA) coatings have been widely used to improve bioactivity of Ti materials aiming to enable a quicker healing process after implantation.…”

Section: Introductionmentioning

confidence: 99%

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Tribocorrosion Behavior of Calcium- and Phosphorous-Enriched Titanium Oxide Films and Study of Osteoblast Interactions for Dental Implants

et al. 2015

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Titanium (Ti) dental implants are frequently exposed simultaneously to a corrosive environment and cyclic micromovements at implant/abutment and implant/ bone interfaces, becoming part of a tribocorrosion system. Thus, wear debris and corrosion products/ions can be released to peri-implant tissues and induce inflammatory reactions leading to implant failure. Moreover, the poor osseointegration is also one of the main problems affecting dental implants lifetime. Surface modification strategies have been proposed to design novel Ti oxide-based multifunctional surfaces that are able to simultaneously improve cellular functions and provide enhanced tribocorrosion resistance. Hence, the main objective of this work was the synthesis of Calcium (Ca)-and Phosphorous (P)-enriched Ti oxide films aimed to display superior wear/corrosion performance and simultaneously, to enhance osteoblast-material interactions. Ca-and P-enriched films were synthesized by plasma electrolytic oxidation (PEO) and their characteristics were assessed by Field emission scanning electron microscopy, profilometry, energy-dispersive X-ray spectroscopy, X-ray diffraction, and water contact angle measurements. PEO-treated samples were subjected to pin-on-disk reciprocating sliding tests in artificial saliva at 37°C. The viability of MG63 cells cultured on PEO-treated samples was investigated by MTT assay, and their adhesion ability by SEM and confocal laser scanning microscopy. The wear/corrosion behavior of Ti was improved after PEO treatments and the electrolyte composition appeared to play a crucial role both on its corrosion tendency and mechanical wear resistance. It is believed that this improvement is related to the higher rutile/anatase ratio exhibited by Ca-and P-enriched surfaces. Osteoblasts were well spread on these surfaces displaying improved viability/proliferation compared to Ti.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tribocorrosion Behavior of Calcium- and Phosphorous-Enriched Titanium Oxide Films and Study of Osteoblast Interactions for Dental Implants

et al. 2015

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“…3). For each parameter considered the Results of static and dynamic quantitative histology (Ravanetti et al, 2010) are detailed below in the text and plotted in the figure (Fig. 4).…”

Section: Resultsmentioning

confidence: 99%

Primary Osteintegration in the Study of Biomimetic Surfaces

Ravanetti¹,

Cacchioli²

2011

On Biomimetics

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“…Last studies carried out have concluded that the PEO surface treatments enhance the biological response "in vitro", promoting early osteoblast adhesion, and the osseointegrative properties "in vivo", accelerating the primary osteogenic response, as they confirmed by the more extensive bone-implant contact reached after 2 weeks of study [94].…”

Section: Plasma Electrolytic Oxidation Treatmentmentioning

confidence: 88%

“…Surface topography plays a fundamental role in regulating cell behaviour, e.g. the shape, orientation and adhesion of cells [93] [94]. As a surface begins to contact with biological tissues, water molecules first reach the surface.…”

Section: Plasma Electrolytic Oxidation Treatmentmentioning

confidence: 99%