In Vitro Characteristics of Surface‐Modified Biphasic Calcium Phosphate/Poly(<scp>L</scp>‐Lactide) Biocomposite

Yang, Weizhong; Yin, Guangfu; Zhou, Di; Gu, Jianwen; Li, Yadong

doi:10.1002/adem.200980025

Cited by 12 publications

(10 citation statements)

References 12 publications

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“…Another research group created porous PDLLA/BCP scaffolds and coated them with a hydrophilic PEG/vancomycin composite for both drug delivery purposes and surface modification [ 414 ]. More to the point, both PLGA/BCP [ 415 , 416 ] and PLLA/BCP [ 417 ] biocomposites were fabricated and their cytotoxicity and fibroblast properties were found to be acceptable for natural bone tissue reparation, filling and augmentation [ 418 , 419 ]. Besides, PCL/BCP [ 420 , 421 ], PTMC/BCP [ 422 ] and gelatin/BCP [ 423 , 424 ] biocomposites are known as well.…”

Section: Biocomposites and Hybrid Biomaterials Containing Capo mentioning

confidence: 99%

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Dorozhkin¹

2015

JFB

131

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The state-of-the-art on calcium orthophosphate (CaPO4)-containing biocomposites and hybrid biomaterials suitable for biomedical applications is presented. Since these types of biomaterials offer many significant and exciting possibilities for hard tissue regeneration, this subject belongs to a rapidly expanding area of biomedical research. Through the successful combinations of the desired properties of matrix materials with those of fillers (in such systems, CaPO4 might play either role), innovative bone graft biomaterials can be designed. Various types of CaPO4-based biocomposites and hybrid biomaterials those are either already in use or being investigated for biomedical applications are extensively discussed. Many different formulations in terms of the material constituents, fabrication technologies, structural and bioactive properties, as well as both in vitro and in vivo characteristics have been already proposed. Among the others, the nano-structurally controlled biocomposites, those containing nanodimensional compounds, biomimetically fabricated formulations with collagen, chitin and/or gelatin, as well as various functionally graded structures seem to be the most promising candidates for clinical applications. The specific advantages of using CaPO4-based biocomposites and hybrid biomaterials in the selected applications are highlighted. As the way from a laboratory to a hospital is a long one and the prospective biomedical candidates have to meet many different necessities, the critical issues and scientific challenges that require further research and development are also examined.

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Section: Biocomposites and Hybrid Biomaterials Containing Capo mentioning

confidence: 99%

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Dorozhkin¹

2015

JFB

131

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“…490 Another research group created porous PDLLA/BCP scaffolds and coated them with a hydrophilic PEG/vancomycin composite for both drug delivery purposes and surface modification. 491 More relevantly, both PLGA/BCP 492,493 and PLLA/ BCP 494 biocomposites were fabricated, and their cytotoxicity and fibroblast properties were found to be acceptable for natural bone tissue reparation, filling and augmentation. 495,496 PCL/BCP 497 and gelatin/BCP 498,499 biocomposites are known as well.…”

Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 99%

Biocomposites and hybrid biomaterials based on calcium orthophosphates

Dorozhkin¹

2011

Biomatter

156

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“…Previous literature has demonstrated an effective approach to increase the powder solid loading in photocurable slurry through surface modification of CaP powders to convert their wettability from hydrophilic to hydrophobic [ 17–19 ]. Surfactants have been widely used to change the affinity between organic and inorganic phases, as they can reduce aqueous solution surface tension or liquid–liquid interfacial tension [ 20 ]. According to the findings of our previous research, MAEP was selected to modify CaP powders in this study.…”

Section: Discussionmentioning

confidence: 99%

Fabrication and biological evaluation of 3D-printed calcium phosphate ceramic scaffolds with distinct macroporous geometries through digital light processing technology

Wang

Tang

Cao

et al. 2022

Regenerative Biomaterials

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Digital light processing (DLP)-based 3D printing technique holds promise in fabricating scaffolds with high precision. Here raw calcium phosphate (CaP) powders were modified by 5.5% monoalcohol ethoxylate phosphate (MAEP) to ensure high solid loading and low viscosity. The rheological tests found that photocurable slurries composed of 50 wt % modified CaP powders and 2 wt % toners were suitable for DLP printing. Based on geometric models designed by CAD system, three printed CaP ceramics with distinct macroporous structures were prepared, including simple cube, octet-truss, and inverse face-centered cube (fcc), which presented the similar phase composition and microstructure, but the different macropore geometries. Inverse-fcc group showed the highest porosity and compressive strength. The in vitro and in vivo biological evaluations were performed to compare the bioactivity of three printed CaP ceramics, and the traditional foamed ceramic was used as control. It suggested that all CaP ceramics exhibited good biocompatibility, as evidence by an even bone-like apatite layer formation on the surface, and the good cell proliferation and spreading. A mouse intramuscular implantation model found that all of CaP ceramics could induce ectopic bone formation, and Foam group had the strongest osteoinduction, followed by Inverse-fcc, while Cube and Octet-truss had the weakest one. It indicated that macropore geometry was of great importance to affect the osteoinductivity of scaffolds, and spherical, concave macropores facilitated osteogenesis. These findings provide a strategy to design and fabricate high-performance orthopedic grafts with proper pore geometry and desired biological performance via DLP-based 3D printing technique.

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In Vitro Characteristics of Surface‐Modified Biphasic Calcium Phosphate/Poly(L‐Lactide) Biocomposite

Cited by 12 publications

References 12 publications

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Biocomposites and hybrid biomaterials based on calcium orthophosphates

Fabrication and biological evaluation of 3D-printed calcium phosphate ceramic scaffolds with distinct macroporous geometries through digital light processing technology

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