In vitro characterization of neurons in the ventral part of the nucleus tractus solitarius. II. Ionic basis for repetitive firing patterns

Dekin, M. S.; Getting, Peter A.

doi:10.1152/jn.1987.58.1.215

Cited by 94 publications

(37 citation statements)

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“…4B). Such behavior strongly suggested the removal of the inactivation of a slowly inactivating subthreshold current similar to the potassium I D current originally described in hippocampal neurons (Bekkers and Delaney 2001;Storm 1988) as well as other CNS neurons (Dekin and Getting 1987;Hammond and Crepel 1992;McCormick 1991;Sah and McLachlan 1992;Spain et al 1991;Storm 1988;Surmeier et al 1992) When type D PHNn were submitted to long-lasting (Ͼ5 s) depolarizing current pulses from particular hyperpolarized levels, they showed a characteristic long delay to the first action potential (dotted line and double arrowhead in Fig. 4C1) after which the membrane potential depolarized slowly and the discharge rate progressively accelerated again, suggesting the presence of an inactivating I D current.…”

Section: Intrinsic and Pharmacological Properties Of Phnnsupporting

confidence: 61%

Oscillatory and Intrinsic Membrane Properties of Guinea Pig Nucleus Prepositus Hypoglossi Neurons In Vitro

Idoux¹,

Serafin²,

Fort³

et al. 2006

Journal of Neurophysiology

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. Numerous models of the oculomotor neuronal integrator located in the prepositus hypoglossi nucleus (PHN) involve both highly tuned recurrent networks and intrinsic neuronal properties; however, there is little experimental evidence for the relative role of these two mechanisms. The experiments reported here show that all PHN neurons (PHNn) show marked phasic behavior, which is highly oscillatory in ϳ25% of the population. The behavior of this subset of PHNn, referred to as type D PHNn, is clearly different from that of the medial vestibular nucleus neurons, which transmit the bulk of head velocity-related sensory vestibular inputs without integrating them. We have investigated the firing and biophysical properties of PHNn and developed data-based realistic neuronal models to quantitatively illustrate that their active conductances can produce the oscillatory behavior. Although some individual type D PHNn are able to show some features of mathematical integration, the lack of robustness of this behavior strongly suggests that additional network interactions, likely involving all types of PHNn, are essential for the neuronal integrator. Furthermore, the relationship between the impulse activity and membrane potential of type D PHNn is highly nonlinear and frequency-dependent, even for relatively smallamplitude responses. These results suggest that some of the synaptic input to type D PHNn is likely to evoke oscillatory responses that will be nonlinearly amplified as the spike discharge rate increases. It would appear that the PHNn have specific intrinsic properties that, in conjunction with network interconnections, enhance the persistent neural activity needed for their function.

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Section: Intrinsic and Pharmacological Properties Of Phnnsupporting

confidence: 61%

Oscillatory and Intrinsic Membrane Properties of Guinea Pig Nucleus Prepositus Hypoglossi Neurons In Vitro

Idoux¹,

Serafin²,

Fort³

et al. 2006

Journal of Neurophysiology

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“…Gestrelius & Grampp, 1983;Kasai, Kameyama & Fukuda, 1986;Penner, Petersen, Pierau & Dreyer, 1986;Stansfeld, Marsh, Halliwell & Brown, 1986;Dekin & Getting, 1987;Quandt, 1988). These currents appear to differ from each other and from the slowtransient current of Betz cells in the details of their pharmacology and voltage dependence.…”

Section: Discussionmentioning

confidence: 82%

Two transient potassium currents in layer V pyramidal neurones from cat sensorimotor cortex.

Spain

Schwindt

Crill

1991

The Journal of Physiology

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4. Both transient currents were evoked by depolarizations below action potential threshold. The fast-transient current was evoked by a 7 mV smaller depolarization than the slow-transient current, but its chord conductance increased less steeply with depolarization.5. Voltage-dependent inactivation of the fast-transient was steeper than that of the slow-transient current (4 vs. 7 mV per e-fold change), and half-inactivation occurred at a less negative potential (-59 vs. -65 mV). The activation and inactivation characteristics of each current overlapped, however, implying the existence of a steady 'window current' extending over a range of 14 mV beginning negative to action potential threshold.6. The fast-transient current displayed a clear voltage dependence of both its activation and inactivation kinetics, whereas the slow-transient current did not. Recovery of either current from inactivation took about 1 s near -70 mV. The recovery of the slow-transient current became faster with hyperpolarization.7.

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“…In the NTS, postsynaptic I K is important in synaptic integration and regulating action potential frequency (Dekin and Getting, 1987;Bailey et al, 2002). Previous evidence for a functional role of Kv1.1 in the NTS comes from studies showing that microinjection of DTX into the NTS alters the baroreceptor and cardiopulmonary reflexes in the intact animal (Butcher and Paton, 1998).…”

Section: Kv11 Deletion Increases Chemosensory Activitymentioning

confidence: 99%

Kv1.1 Deletion Augments the Afferent Hypoxic Chemosensory Pathway and Respiration

Kline¹,

Buniel²,

Glazebrook³

et al. 2005

J. Neurosci.

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Mutations in the potassium channel gene Kv1.1 are associated with human episodic ataxia type 1 (EA-1) syndrome characterized by movement disorders and epilepsy. Ataxic episodes in EA-1 patients are often associated with exercise or emotional stress, which suggests a prominent role for the autonomic nervous system. Many of these alterations are reproduced in the Kv1.1-null mouse. Kv1.1 also regulates excitability of sensory neurons essential in cardiovascular and respiratory reflexes. We examined the neural control of the respiratory system of littermate wild-type (control) and Kv1.1-null mice during low O 2 (hypoxia). Immunohistochemical studies demonstrated Kv1.1 in the afferent limb of the carotid body chemoreflex (the major regulator in the response to hypoxia), consisting of the carotid body, petrosal ganglion, and nucleus of the solitary tract (NTS). Respiration was examined by plethysmography. Null mice exhibited a greater increase in respiration during hypoxia compared with controls. In vitro carotid body sensory discharge during hypoxia was greater in null than control mice. In the caudal NTS, evoked EPSCs in brainstem slices were similar between control and null mice. However, the frequency of spontaneous and miniature EPSCs was greater in null mice. Null mice also exhibited more asynchronous release after a stimulus train. These results demonstrate the important role of Kv1.1 in afferent chemosensory activity and suggest that mutations in the human Kv1.1 gene have functional consequences during stress responses that involve respiratory reflexes.

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In vitro characterization of neurons in the ventral part of the nucleus tractus solitarius. II. Ionic basis for repetitive firing patterns

Cited by 94 publications

References 0 publications

Oscillatory and Intrinsic Membrane Properties of Guinea Pig Nucleus Prepositus Hypoglossi Neurons In Vitro

Oscillatory and Intrinsic Membrane Properties of Guinea Pig Nucleus Prepositus Hypoglossi Neurons In Vitro

Two transient potassium currents in layer V pyramidal neurones from cat sensorimotor cortex.

Kv1.1 Deletion Augments the Afferent Hypoxic Chemosensory Pathway and Respiration

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