In-Vitro Characterization of the Aerosolized Dose During Non-Invasive Automatic Continuous Positive Airway Pressure Ventilation

Hassan, A.; Rabea, Hoda; Hussein, Raghda R. S.; Eldin, Randa Salah; Abdelrahman, Maha M.; Said, Amira S. A.; Salem, Heba F.; Abdelrahim, Mohamed

doi:10.1007/s41030-015-0010-y

Cited by 64 publications

(60 citation statements)

References 29 publications

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“…Similar to many previous studies, VMN provided higher USAL0.5, hence a higher pulmonary bioavailability, than JET [9,15,16,[27][28][29]. That means higher effi ciency of the VMN in aerosol drug delivery.…”

Section: Discussionsupporting

confidence: 79%

“…That means higher effi ciency of the VMN in aerosol drug delivery. Moreover, MDI with spacer signifi cantly increased the relative pulmonary bioavailability (USAL0.5%) compared to JET and VMN [14,16] and that could be because we synchronized the MDI dose delivery and the patient inhalation which increased the lung deposition [16,30].…”

Section: Discussionmentioning

confidence: 99%

“…As recommended previously by many studies [15,16], the inhalation devices were placed closed to the patient in the ventilator circuit as shown in Figure 1.…”

Section: Methodsmentioning

confidence: 99%

“…Actuations of the sixteen puffs were synchronized with the start of patients' inspiration for better aerosol delivery [16,17].…”

Section: Methodsmentioning

confidence: 99%

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Effects of Heat and Humidification on Aerosol Delivery during Auto-CPAP noninvasive Ventilation

Abdelrahim¹

2017

Arch Pulmonol Respir Care

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Objective: Although, the use of humidifi cation during non-invasive ventilation (NIV) is an important factor in decreasing nasal airway resistance and assuring patient's comfort and adherence; many in-vitro studies recommend switching off the humidifi er while delivering aerosol to NIV patients.The aim of the study was to in-vivo determine the effect of humidifi cation on salbutamol delivered via different inhalation devices to chronic obstructive pulmonary disease (COPD) patients using automatic continuous positive airway pressure (Auto-CPAP).Method: Aerosol delivery to NIV COPD patients by Aerogen Solo vibrating mesh nebuliser (VMN), Jet nebuliser (JET) and a metered dose inhaler (MDI) with AeroChamber MV spacer (AC) were compared with and without humidifi cation. Auto-CPAP was adjusted at non-invasive ventilation mode with the integrated heated humidifi er (IHH), as a source of humidity. The heater was set to the default setting 3, equivalent to 50ºC. Urine samples, 30 minutes and 24 hours post inhalation, as an index of the relative pulmonary and systemic bioavailability respectively, were provided by subjects and aliquots were retained for salbutamol analysis using solid phase extraction and high performance liquid chromatography (HPLC). Results:There was no signifi cant difference in the urinary excreted salbutamol post inhalation between the humidifi ed and dry conditions. However, there was a signifi cant difference between devices. The MDI with AC spacer had the highest percentage of 30 minutes urinary excreted salbutamol and JET had the lowest (p<0.01). VMN the highest percentage of 24 hours urinary excreted salbutamol and JET had the lowest but the difference was not signifi cant. Conclusion:Signifi cance of switching off humidity during aerosol delivered to ventilated patient was not as previously shown in in-vitro literatures. We recommend delivering aerosol medication to Auto-CPAP NIV patient using humidity without fear of lower delivery.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

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Effects of Heat and Humidification on Aerosol Delivery during Auto-CPAP noninvasive Ventilation

Abdelrahim¹

2017

Arch Pulmonol Respir Care

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“…Aerosol delivery in non-invasive ventilation (NIV) was proven to be of benefit and has been well studied [5,[7][8][9][10][11]. However, the effect of the change of design of nebulizers with the same mechanism on delivery has not been studied much.…”

Section: Introductionmentioning

confidence: 99%

Effect of Nebulizer Designs on Aerosol Delivery During Non-Invasive Mechanical Ventilation: A Modeling Study of In Vitro Data

et al. 2017

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Introduction: Nebulizers used to deliver aerosol during non-invasive mechanical ventilation (NIV) have many types, each type has many different designs. This study aimed to determine the effect of nebulizer deign on aerosol delivery in NIV. Methods: Different designs of jet nebulizer (JN) and vibrating mesh nebulizer (VMN) were tested by placing 1 ml of salbutamol in a nebulizer chamber operated in an in vitro NIV setting using a breathing simulator with adult settings (inhalation-exhalation ratio 1:3, 15 breaths/

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Effect of Postoperative Atrial Fibrillation After Cardiac Surgery: A Meta‐Analysis

Qu,

Yang,

et al. 2024

Clinical Cardiology

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BackgroundA meta‐analysis study was conducted to determine how to predict the effect of postoperative atrial fibrillation after cardiac surgery.HypothesisLong‐term mortality and cardiovascular morbidity are linked to postoperative atrial fibrillation.MethodUntil August 2024, a comprehensive literature study was completed, and 3486 connected studies were revised. The 38 selected studies included 241 299 cardiac surgery participants at the beginning of the study. The odds ratio (OR) and 95% confidence intervals (CIs) were used to look at the effect of atrial fibrillation after heart surgery using two‐sided methods and either a fixed or random model.ResultsIndividuals with cardiac surgery with postoperative atrial fibrillation had significantly higher mortality at 1 year (OR, 1.39; 95% CI, 1.12–1.72, p < 0.001), mortality at 5 years (OR, 1.61; 95% CI, 1.33–1.94, p < 0.001), mortality at 10 years (OR, 1.61; 95% CI, 1.39–1.87, p < 0.001), and overall stroke (OR, 1.61; 95% CI, 1.34–1.94, p < 0.001) compared to without postoperative atrial fibrillation.ConclusionsIndividuals with cardiac surgery with postoperative atrial fibrillation had significantly higher mortality at 1 year, mortality at 5 years, mortality at 10 years, and overall stroke compared to those without postoperative atrial fibrillation. To validate this discovery, more research and caution must be implemented when interacting with its values.

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In-Vitro Characterization of the Aerosolized Dose During Non-Invasive Automatic Continuous Positive Airway Pressure Ventilation

Cited by 64 publications

References 29 publications

Effects of Heat and Humidification on Aerosol Delivery during Auto-CPAP noninvasive Ventilation

Effects of Heat and Humidification on Aerosol Delivery during Auto-CPAP noninvasive Ventilation

Effect of Nebulizer Designs on Aerosol Delivery During Non-Invasive Mechanical Ventilation: A Modeling Study of In Vitro Data

Effect of Postoperative Atrial Fibrillation After Cardiac Surgery: A Meta‐Analysis

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