In vitro chondrocyte interactions with TiO2 nanofibers grown on Ti–6Al–4V substrate by oxidation

Proliferation and stemness preservation of human adipose-derived stem cells by surface-modified in situ TiO2 nanofibrous surfaces

“…31 Our more recent studies also showed that these nanofibrous surface structures are suitable for use as an effective substrate for cartilaginous applications. 28 In this study, the results indicated that TiO 2 nanofibrous substrate triggers enhanced chondrocyte adhesion, proliferation, and production of extracellular matrix (ECM) fibrils when compared to a flat control substrate.…”

“…28,30,31 Our own studies with human osteosarcoma (HOS)-derived cell line on these nanofibrous surfaces revealed improved cell adhesion and cell proliferation on TiO 2 NF-coated substrate compared to the other counterparts. 31 Our more recent studies also showed that these nanofibrous surface structures are suitable for use as an effective substrate for cartilaginous applications.…”

“…27 Various morphologies of TiO 2 have been introduced onto the surfaces of Ti-based substrates, including nanotubes, nanofibers (NFs), and nanorods and they can be fabricated by various techniques such as electrospinning, anodization, and hydrothermal treatment. 28 However, some of these methods give rise to several concerns such as the problems of phase purity, crystallinity, and incorporation of impurity. 29 For example, the crystallinity of TiO 2 nanostructures prepared by electrospinning and anodization is usually not satisfactory and thus additional heat treatment is needed to improve the crystallinity of TiO 2 nanostructures.…”

“…28,31 To explain briefly, Ti-6Al-4V discs (grade #5, Titan Engineering Pte Ltd, Singapore) of size ø 6.35×2 mm were employed as test substrates. The discs were polished using silicon carbide (SiC) sandpaper of grit 1,200 prior to the oxidation treatment.…”

Surface Patterning of Functional Ceramics: A Materials Design

“…This process has been successfully demonstrated on bulk, foil, thin film, and particles of commercially pure Ti and Ti alloys including Ti64 (Ti-6 wt% Al-4 wt% V) that is widely used as a hip implant material. Patterned surfaces by this oxidation process has lately been used in various biomedical applications (Dinan et al, 2013;Tan et al, 2014aTan et al, ,b, 2016). …”