In vitro clastogenicity of the aporphine-type alkaloids

Tadaki, Shinichi; Nozaka, Tomio; Ishino, Masazo; Tanaka, A.; Morimoto, Isao; Kunitomo, Jun-ichi

doi:10.1016/0165-1161(91)90226-x

“…Liriodenine was found to be the most active alkaloid. The same research group investigated the clastogenicity of 18 related aporphines in the chromosomal aberration test in vitro, using a Chinese hamster lung cell line (Tadaki et al, 1991). Although the alkaloids showed mutagenicity to Salmonella strains only in the presence of S9 mix, many of the compounds tested induced chromosomal aberrations in the absence as well as in the presence of rat liver enzymes.…”

Section: Significant Endogenous Mutagens/carcinogensmentioning

confidence: 99%

Molecular Modes of Action of Defensive Secondary Metabolites

Wink

¹

,

Schimmer

²

2010

Functions and Biotechnology of Plant Secondary Metabolites

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Secondary metabolites (SM) have been shaped by evolution for more than 500 million years. As a result, many of them have distinctive biochemical and pharmacological properties. The molecular modes of action of the main groups of SM are reviewed in this chapter. Details are given on interactions of SM with proteins that can induce conformational changes and thus a modification of their bioactivity. The fluidity and permeability of biomembranes constitute another important target, which is influenced by many lipophilic and amphiphilic SM. A number of SM can either alkylate or intercalate DNA, which can cause mutations and in consequence cancer or malformations. Many SM are cytotoxic because they interfere with biomembranes, proteins of the cytoskeleton or DNA; they often induce programmed cell death (apoptosis). A large number of SM, especially alkaloids modulate neuronal signal transduction by interfering with ion channels, ion pumps, neuroreceptors, choline esterase, monoamine oxidase and other enzymes related to signal transduction pathways. A typical feature of SM is their ability to modulate more than one molecular target; thus, additive and even synergistic activities can be expected.

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Modes of Action of Defensive Secondary Metabolites

Wink

¹

,

Schimmer

²

2018

Annual Plant Reviews Online

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show abstract

Molecular Modes of Action of Defensive Secondary Metabolites

Wink¹,

Schimmer²,

Roberts³

et al. 2018

Annual Plant Reviews Online

View full text Add to dashboard Cite

Secondary metabolites (SM) have been shaped by evolution for more than 500 million years. As a result, many of them have distinctive biochemical and pharmacological properties. The molecular modes of action of the main groups of SM are reviewed in this chapter. Details are given on interactions of SM with proteins that can induce conformational changes and thus a modification of their bioactivity. The fluidity and permeability of biomembranes constitute another important target, which is influenced by many lipophilic and amphiphilic SM. A number of SM can either alkylate or intercalate DNA, which can cause mutations and in consequence cancer or malformations. Many SM are cytotoxic because they interfere with biomembranes, proteins of the cytoskeleton or DNA; they often induce programmed cell death (apoptosis). A large number of SM, especially alkaloids modulate neuronal signal transduction by interfering with ion channels, ion pumps, neuroreceptors, choline esterase, monoamine oxidase and other enzymes related to signal transduction pathways. A typical feature of SM is their ability to modulate more than one molecular target; thus, additive and even synergistic activities can be expected.

show abstract

In vitro clastogenicity of the aporphine-type alkaloids

Cited by 3 publications

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Molecular Modes of Action of Defensive Secondary Metabolites

Molecular Modes of Action of Defensive Secondary Metabolites

Modes of Action of Defensive Secondary Metabolites

Molecular Modes of Action of Defensive Secondary Metabolites

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