In vitro Comparative Activity of Moxalactam, GR 20263, and N-Formimidoyl Thienamycin to Other Beta-Lactam Antibiotics and Tobramycin against Enterobacteriaceae and Staphylococci

Cynamon, Michael H.; Granato, Paul A.

doi:10.1159/000238077

Cited by 6 publications

(2 citation statements)

References 7 publications

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“…The third generation cephalosporins and moxalactam have been suggested as potential single agents for broad spectrum antimicrobial therapy but extensive clini cal studies documenting this indication have not been carried out [2]. Our data showed that either cefoperazone, cefotax ime or moxalactam inhibited 95% of 148 Enterobacteriaceae at an M IC^ 1.6 ug/ml and suggest that these agents might well be effective in community hospital infections with these organisms.…”

Section: Discussionmentioning

confidence: 64%

“…Species of bacteria and number of each (in paren theses) included E. coli (78), K. pneumoniae (26), K. oxytoca (5), E. aerogenes (7), E. agglomerans (l), E. cloacae (9), P. mirabilis (8), P. rettgeri (2), M. morganii (1), S. flexneri (1), S. marcescens (3), C. freundii (1), C. diversus (2), Salmonella, group D (1), Salmo nella group B (2), Salmonella, group C (1), P. aerugi nosa (16), P. cepacia (3), P. pseudoalcaligenes (1) and A. calcoaceticus (2). Gordon/Tack/Haddy/Fechner/Wofford…”

Section: Methodsmentioning

confidence: 99%

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Antibiotic Susceptibility of Community Hospital Blood Culture Isolates of Gram-Negative Bacilli

et al. 1984

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The comparative in vitro activity of amikacin, cefamandole, cefoperazone, cefotaxime, cefoxitin, cephalothin, chloramphenicol, moxalactam, piperacillin, ticarcillin and tobramycin against 170 community blood culture isolates of gram-negative bacilli was investigated using the quantitative plate dilution method. Results showed that amikacin, cefoperazone, cefotaxime, moxalactam, piperacillin and tobramycin were most active on a weight basis. Tobramycin and amikacin were quite active against Pseudomonas aeruginosa but one isolate showed an MIC of 50 μg/ml to both. The order of activity of the remaining drugs for P. aeruginosa was cefoperazone > moxalactam > cefotaxime and piperacillin > ticarcillin.

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Section: Discussionmentioning

confidence: 64%

Section: Methodsmentioning

confidence: 99%

Antibiotic Susceptibility of Community Hospital Blood Culture Isolates of Gram-Negative Bacilli

et al. 1984

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Vergleichende In vitro-Studie zur antimikrobiellen Aktivität von Ceftazidim gegen klinische Isolate

1987

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The antimicrobial activity of ceftazidime was tested against 1482 gram-negative and 1216 gram-positive strains isolated from fresh clinical specimens and compared with generally used antibiotics including other third generation cephalosporins and broad spectrum penicillins. Minimal inhibitory concentrations were determined in a broth dilution test on microtiter plates. In the group of the gram-negative bacteria ceftazidime was the most active of the antimicrobial agents tested with an MIC of 0.5 mg/l (MIC90) for most of the isolates. Ceftazidime exhibited a broad spectrum of activity against gram-negative pathogenic bacteria including Enterobacteriaceae (Escherichia coli, Klebsiella spp., Proteus spp. Enterobacter spp., Citrobacter spp., Serratia spp.) including frequently resistant strains of Pseudomonas aeruginosa, Acinetobacter spp. and Alcaligenes faecalis. The activity against P. aeruginosa is the most remarkable property of the agent. Ceftazidime is less effective against gram-positive compared to gram-negative bacteria. No inhibitory action can be observed against Streptococcus faecalis.

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In vitro activity of imipenem — A review

Braveny¹

1984

Eur. J. Clin. Microbiol.

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A review is given of the microbiological properties of imipenem, a new carbapenem antibiotic with an exceptionally broad spectrum of antibacterial activity. An evaluation of results of numerous in vitro studies reveals that imipenem effectively inhibited growth of 53 of 55 bacterial species, the mean MIC90 being less than 8 mg/l. The MIC90 for cocci, with the exception of Staphylococcus epidermidis, is in the range of 0.01-3.1 mg/l. The MIC90 for all Enterobacteriaceae is equal to or less than 8 mg/l. Pseudomonas aeruginosa and other non-fermentative gram-negative bacteria are generally susceptible to imipenem, only Pseudomonas maltophilia and Pseudomonas cepacia showing intrinsic resistance. Imipenem is currently the most active drug available against anaerobic bacteria, the MIC usually being below 1 mg/l even for Bacteroides fragilis. Rare bacteria such as Nocardia asteroides, Listeria monocytogenes or fast growing Mycobacterium spp. which cause difficult-to-treat infections are also susceptible to imipenem. Increases in inoculum size have only a minimal effect on activity of the drug. In most species the MBC only slightly exceeded the MIC; however in the case of Streptococcus faecalis the MBC value was many times the MIC value. Synergism has been observed in combinations of imipenem with aminoglycosides, and antagonism in combinations with other beta-lactam antibiotics against Pseudomonas aeruginosa and Serratia marcescens. Imipenem is stable in the presence of the common chromosomal and plasmid-mediated enzymes. Induction of inactivating enzymes was observed in staphylococci, Pseudomonas aeruginosa and Serratia marcescens.

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In vitro Comparative Activity of Moxalactam, GR 20263, and N-Formimidoyl Thienamycin to Other Beta-Lactam Antibiotics and Tobramycin against Enterobacteriaceae and Staphylococci

Cited by 6 publications

References 7 publications

Antibiotic Susceptibility of Community Hospital Blood Culture Isolates of Gram-Negative Bacilli

Antibiotic Susceptibility of Community Hospital Blood Culture Isolates of Gram-Negative Bacilli

Vergleichende In vitro-Studie zur antimikrobiellen Aktivität von Ceftazidim gegen klinische Isolate

In vitro activity of imipenem — A review

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