In vitro Comparative Study for Anti-proliferative Activity of Some Plant Extracts, Fam. Apiaceae, on HeLa Cell Line

Abstract

In this research, the biological activities of five plant extracts from family Apiaceae; Italian Parsley (Petroselinum neapolitanum), Fennel (Foeniculum vulgare), Celery (Apium graveolens), Cilantro (Coriandrum sativum) and Dill (Anethum graveolens), were studied. Antiproliferative effect of eleven ethanol crude extracts was tested in Human Cervical (HeLa) cancer cells. Parsley leaves extract, cilantro leaves extract and cilantro stems extract showed no significant difference with the positive control (Actinomycin D). As for, fennel bulb extracts, fennel stalks extracts, celery stems gave better results than the positive control with no significant difference through the 24, 48 and 72h treatment. There were no significant difference between Fennel extracts and the positive control, which showed high effect on the cancer cells survival. There were no significant difference between both extracts of Cilantro leaves and stems through each time but the best result was after 72h of treatments. Regarding Dill leaves and stems, cell numbers recorded no significant difference between the both on time dependent manner. Further investigation for ethanolic extracts of parsley leaves, fennel bulb, fennel stalks, celery stems, cilantro leaves and cilantro stems which showed better results than using the commercial drug Actinomycin D (25L/mL) for 24h treatment or less depending on concentrations manner. Also, further investigation on different types of cancer cell lines to avoid the toxic effect of chemotherapy.

Froriepia subpinnata Leaf Extract-Induced Apoptosis in the MCF-7 Breast Cancer Cell Line by Increasing Intracellular Oxidative Stress

“…The plants of this family are famous for their medicinal properties, such as estrogenic, anti-inflammatory, anticancer, antiproliferative, cytotoxic, antimicrobial, and anti-neoplastic effects. Since Apiaceae are a very important source of phytochemicals, bioactive compounds with nutritional potential, polyphenolic compounds, polyethylenes, and terpenoids, they are used for cancer prevention and treatment (31)(32)(33). Also, the anticancer properties of several plants from this family, such as Ferulago Mughlea Pes ¸men, Seseli petraeum, and Petroselinum crispum, have been investigated in other research studies (33)(34)(35).…”

“…Since Apiaceae are a very important source of phytochemicals, bioactive compounds with nutritional potential, polyphenolic compounds, polyethylenes, and terpenoids, they are used for cancer prevention and treatment (31)(32)(33). Also, the anticancer properties of several plants from this family, such as Ferulago Mughlea Pes ¸men, Seseli petraeum, and Petroselinum crispum, have been investigated in other research studies (33)(34)(35). This is the first study of the anticancer and apoptosis-inducing properties of F. subpinnata on cancer.…”