In-vitro Comparison of Anti-Microbial Efficacy and Enamel Microhardness after Application of Two Types of Fluoride Varnishes

Bapat, S. A.; Shashikiran, N D; Gaugawd, Sachin; Gaonkar, Namrata; Taur, Swapnil; Hadakar, Savita; Chaudhari, Pradnya

doi:10.7860/jcdr/2020/43917.13627

Cited by 2 publications

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“…[ 19 ] Risk of bias item randomization and allocation concealment were considered low risk as the samples (human teeth enamel) used were homogenous. [ 18 ] Overall, 7[ 26 31 32 34 38 ] of the 18 included studies had unclear risk of bias and rest 11[ 10 11 24 27 29 30 33 35 36 37 39 ] had low risk of bias. The risks of bias of the included studies are summarized in Table 4 [ Figure 3 ].…”

Section: Resultsmentioning

confidence: 99%

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Efficacy of casein phosphopeptide-amorphous calcium phosphate varnish in remineralizing white spot lesions: A systematic review and meta-analysis

et al. 2022

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Background: This systematic review aimed to evaluate the efficacy of casein phosphopeptide-amorphous calcium phosphate (CPP-ACPF) varnish for remineralization of white spot lesions (WSLs) “ in vitro ” in human teeth. Materials and Methods: Literature search included three databases, namely Medline (via PubMed), The Cochrane Controlled Clinical Trials Register, and Google Scholar from 2010 to January 2021. The studies assessing WSL depth, calcium, phosphate ion release, and microhardness due to artificial demineralization or remineralization were considered for review. Reference articles were retrieved, and a customized risk assessment tool was used. The Cochrane risk of bias assessment tool was used to generate the risk of bias summary graph. Meta-analysis was performed using RevMan 5.4. Heterogeneity was evaluated by Cochrane's test, and random effects model was used to pool estimate of effect and its 95% confidence intervals (CIs) for surface microhardness. Results: Eighteen studies were selected for review based on the eligibility criteria. Four studies showed superior remineralizing effect of CPP-ACPF compared to fluoride varnishes. Four studies involving 120 human permanent teeth samples were included in the meta-analysis. Efficacy of CPP-ACPF varnish was equivalent to other fluoride varnishes in improving surface microhardness after remineralization during 7-day period (mean surface microhardness: 3.94, 95% CI [−9.08–1.21], I 2: 75%, P = 0.13). Major risks of bias associated with the studies included in the review were inadequate sample size, improper sample preparation, and unexplained blinding. Conclusion: CPP-ACPF varnish appears to be equally effective as other fluoride varnishes in remineralizing artificially induced WSLs, but quality of evidence is low.

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Section: Resultsmentioning

confidence: 99%

“…CPP-ACPF varnish groups recorded significantly harder enamel than no treatment groups [ Table 5 ]. [ 24 27 28 29 31 32 34 ]…”

Section: Resultsmentioning

confidence: 99%

Efficacy of casein phosphopeptide-amorphous calcium phosphate varnish in remineralizing white spot lesions: A systematic review and meta-analysis

et al. 2022

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“…After applying two fluoride varnishes containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and xylitol, Bapat et al . [ 15 ] assessed the antimicrobial efficiency against S. mutans and enamel surface microhardness. They discovered that against S. mutans , MI varnish showed more antibacterial activity than Pulpdent embrace varnish.…”

Section: Discussionmentioning

confidence: 99%

“…Remineralization effect of fluoride is its ability to reduce acid formation by fermentation of carbohydrates by S. mutans in dental plaques or reduction in S. mutans count in saliva. [ 15 ] Fluor protector fluoride varnish 1 mm ampoules by IvoclarVivadent spreads easily and readily flows into complex surface structures, dries quickly, and shows excellent adhesion to teeth. [ 12 ] SDF has shown good antibacterial efficacy and can be used to prevent the progress of dental caries in children.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Antibacterial Effectiveness of SDF and Fluoride Varnish Agents for Application in Pediatric Dentistry

Alessa,

Bidyasagar Bal,

Beegum

et al. 2024

Journal of Pharmacy and Bioallied Sciences

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Objectives: To assess antibacterial effects of silver diamine fluoride (SDF) and fluoride varnish treatment against Streptococcus mutans and Lactobacillus acidophilus Materials and Methods: The antibacterial effectiveness of SDF (group A) and fluoride varnish (group B) against S. mutans was investigated in an in vitro microbiological investigation, with distilled water (group C) serving as the positive and negative controls. After 24 hours of incubation, the antibacterial efficiency was assessed using the agar well diffusion technique, and the diameter of the zones of inhibition (ZOI) was quantified. Sumba mare’s milk from MRS broth was extracted and then placed into a test tube. L. acidophilus was grown on Sumba mare’s milk from MRS broth. On this media, each testing agent was poured and tested for the inhibitory zone. The obtained data was statistically analyzed. Results: SDF group had a higher mean zone of inhibition against S. mutans and Lactobacillus followed by fluoride varnish, and there was no ZOI in the case of distilled water. Intergroup comparison was significant Conclusion: When compared to fluoride varnish, the SDF teeth remineralizing agent had greater antibacterial activity against S. mutans.

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In-vitro Comparison of Anti-Microbial Efficacy and Enamel Microhardness after Application of Two Types of Fluoride Varnishes

Cited by 2 publications

References 0 publications

Efficacy of casein phosphopeptide-amorphous calcium phosphate varnish in remineralizing white spot lesions: A systematic review and meta-analysis

Efficacy of casein phosphopeptide-amorphous calcium phosphate varnish in remineralizing white spot lesions: A systematic review and meta-analysis

Assessment of Antibacterial Effectiveness of SDF and Fluoride Varnish Agents for Application in Pediatric Dentistry

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