In Vitro Comparison of Biological Effects of Coe-Pak and Reso-Pac Periodontal Dressings

Kadkhodazadeh, Mahdi; Baghani, Zahra; Torshabi, Maryam; Basirat, Bahar

doi:10.5037/jomr.2017.8103

Cited by 19 publications

(20 citation statements)

References 38 publications

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“…At all evaluation times, Reso-pac had fewer cytotoxicity effects than Coe-pak. The results of this study were in accordance with Kadkhodazadeh's study, 8 that showed a difference in cytotoxicity of Reso-pac and Coe-pak groups in their day one extracts. However, in their results, Reso-pac had no-time.…”

Section: Discussionsupporting

confidence: 91%

“…No allergic reactions have been reported until now. 8 The use of periodontal dressings is increasing in routine practice since there is still no agreement regarding their positive effects on wound healing after surgery. 6 Greater patient comfort with dressing usage seems to be an important factor in favor of their application.…”

Section: Introductionmentioning

confidence: 99%

“…13 Kadkhodazadeh et al studied Resopac cytotoxicity in comparison to Coe-pak and showed slightly less cytotoxicity of Reso-pac than Coe-pak. 8 Since Reso-pac seems to be a dressing with favorable characteristics, we decided to compare its clinical efficacy and evaluate its cytotoxic characteristics on gingival fibroblasts with the more popular Coe-pack dressing.…”

Section: Introductionmentioning

confidence: 99%

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Clinical and Cytotoxic Comparison of Two Periodontal Dressings after Periodontal Flap Surgery

Gholami¹,

Ansari-Moghadam²,

Sadeghi³

et al. 2019

World Journal of Dentistry

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Aim: Postoperative coverage of periodontal surgery sites can help protect the treated area, facilitate wound healing and decrease postperiodontal surgery pain. The aim of this study was to compare the cytotoxic and clinical efficacy of two periodontal dressings after periodontal flap surgery. Materials and methods:In this study 23 patients requiring modified Widman flap in at least two quadrants in the same arch were selected; one quadrant was dressed with Reso-pac, and the other was dressed with Coe-pak. The clinical efficacy of these two dressings was evaluated by comparing plaque, granulation tissue formation, pain, bleeding on probing, and color of gingiva. To compare their cytotoxicity, human gingival fibroblast were exposed to 1-and 3-day extracts of the dressings and MTT test was used to measure cell viability after 24 and 48 hours. Cell apoptosis and necrosis were evaluated by flow cytometric analysis. Data were analyzed by Chi-square and independent t-test and SPSS 20 Software.Results: Plaque and granulation tissue formation rates were significantly lower in Reso-pac covered sites compared to coe-pak (p value < 0.001). Other variables including pain, bleeding and gingival color did not show any significant differences (p value 0.05). Viable fibroblast cells were higher for Resopac compared to Coe-pak (p < 0.05). A higher percentage of necrotic cells in the day one Coe-pak extract group after 24 and 48 hours were observed compared to Reso-pac (6.23 and 4.97 vs. 2.71 and 2.76%). Conclusion:According to our results, Reso-pac is as effective as Coe-pack. It also has further positive effects of less plaque accumulation and granulation tissue formation and is more biocompatible for HGF cells with less cytotoxic effects on cells in the first days after surgery.Clinical significance: Reso-pac may be considered as a dressing of choice in periodontal surgeries with less plaque accumulation and granulation tissue formation plus better biocompatibility and ease of application compared to Coe-pak.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical and Cytotoxic Comparison of Two Periodontal Dressings after Periodontal Flap Surgery

Gholami¹,

Ansari-Moghadam²,

Sadeghi³

et al. 2019

World Journal of Dentistry

View full text Add to dashboard Cite

show abstract

“…As a result of its self‐attachment to surfaces, flexibility, and softness, BC can also be a good candidate in other dental medicine applications, such as temporal implant in dental extraction alveoli or wound dressing after mucosal implantation . However, although the recognized improved epithelialization and decreased inflammatory reactions during the use of BC‐based periodontal dressing materials, the number of studies of its application in this area is scarce.…”

Section: Applicationsmentioning

confidence: 99%

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Carvalho

Guedes

Sousa

et al. 2019

Biotechnology Journal

127

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Bacterial cellulose (BC) is a nanocellulose form produced by some nonpathogenic bacteria. BC presents unique physical, chemical, and biological properties that make it a very versatile material and has found application in several fields, namely in food industry, cosmetics, and biomedicine. This review overviews the latest state‐of‐the‐art usage of BC on three important areas of the biomedical field, namely delivery systems, wound dressing and healing materials, and tissue engineering for regenerative medicine. BC will be reviewed as a promising biopolymer for the design and development of innovative materials for the mentioned applications. Overall, BC is shown to be an effective and versatile carrier for delivery systems, a safe and multicustomizable patch or graft for wound dressing and healing applications, and a material that can be further tuned to better adjust for each tissue engineering application, by using different methods.

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“…The surgical wound was covered by Coe-pak © and left in place about a week to facilitate quick healing [ Figure 1a – d ]. [ 1 ] Amoxicillin was prescribed as a prophylactic drug to all the patients for 5 days in addition to nonsteroidal anti-inflammatory drugs and instructed to use chlorhexidine 0.2% twice daily as an antiplaque agent for 4 weeks. [ 2 ],[ 3 ] The excised tissues were sent in 10% formalin-containing bulb to the department of oral and maxillofacial pathology for histopathology.…”

Section: Case Reportmentioning

confidence: 99%

Evaluation of clinico-pathological reports and recurrence of 20 cases of localized gingival overgrowths

Bhutada¹,

Mishra²,

Ansari³

et al. 2017

J Indian Soc Periodontol

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The aim of the present study was to assess the clinico-histopathological picture and to examine the recurrence of various localized hyperplastic gingival growths after their surgical treatment. Twenty patients of localized hyperplastic gingival outgrowth were evaluated in the present clinico-histopathological study. The data regarding age, sex, location, size, and duration of lesion were summarized. After 4 weeks of initial therapy, an excision of the growth with conventional flap surgery was performed. The excised tissues were sent for histopathological analysis, and the lesions were reclassified into four groups. All the patients were recalled after 3 and 6 months to study the recurrence of the growth. Twenty lesions were inspected, the pyogenic granuloma was the most common (55%), followed by peripheral fibroma (25%), peripheral giant cell granuloma (15%), and calcifying fibroblastic fibroma (5%). Out of the twenty lesions evaluated, the pyogenic granuloma was the most common with no recurrence in any case.

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In Vitro Comparison of Biological Effects of Coe-Pak and Reso-Pac Periodontal Dressings

Cited by 19 publications

References 38 publications

Clinical and Cytotoxic Comparison of Two Periodontal Dressings after Periodontal Flap Surgery

Clinical and Cytotoxic Comparison of Two Periodontal Dressings after Periodontal Flap Surgery

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Evaluation of clinico-pathological reports and recurrence of 20 cases of localized gingival overgrowths

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