In vitro Comparison of Self versus Professionally Applied Remineralizing Materials

Abstract

Objective: To compare the effect of 4 remineralizing materials on the incipient artificial carious lesion and its proximal sound enamel when used with fluoride dentifrice. Study Design: Models mimicking proximal contact were made, each of which was placed with an artificial carious specimen in contact with a sound enamel specimen. Each carious specimen was treated with one of four materials: glass ionomer cement (GIC), resin modified glass ionomer cement (RMGIC), 5000 ppm sodium fluoride (F-gel), and casein phosphopeptide amorphous calcium phosphate (CPP-ACP). The GIC and RMGIC specimens were thermocycled. Then all specimens were pH-cycled for 5 days with twice a day soaking in 1,000 ppm NaF dentifrice solution. Specimens were examined by polarized light microscopy and lesion area quantified by image analysis. Results: RMGIC significantly yielded smaller areas of lesion than CPP-ACP and GIC (p<0.05). F-gel reduced more area of lesion than CPP-ACP significantly (p<0.05). In the associated contact, RMGIC significantly reduced the area of lesion better than CPP-ACP (p<0.05). Conclusions: The most effective remineralizing material in reducing the carious lesion areas was RMGIC followed by F-gel, GIC and CPP-ACP. The demineralization inhibitory effects on the associated sound contact enamel followed the same trend.

A Clinical and Laboratory Evaluation of Different Remineralizing Agents Used for Treatment of Carious Posterior Teeth

“…However these results were not in agreement with Trairatvorakul et al, 2010 (11) , who found that the CPP-ACP was the least efficacious treatment in both preventing demineralization of the intact enamel specimens and in remineralizing the artificial carious specimens. This difference was attributed to the fact that their study was performed in the absence of an oral microbial environment or plaque accumulation on the tooth surfaces, which may have resulted in decreased CPP-ACP adherence to the tooth surfaces since CPP-ACP has been suggested to be incorporated into plaque by binding to bacterial cell surfaces and to intercellular plaque matrix.…”

Casein phosphopeptide-amorphous calcium phosphate and glass ionomer show distinct effects in the remineralization of proximal artificial caries lesion in situ

“…This maintains high concentrations of calcium and phosphate ions in subsurface lesions promoting enamel remineralization 9) . Self-applied CPP-ACP and professionally-applied GI have remineralizing ability as assayed by reduction in lesion area or depth 10,11) . However, their effect on mineral density is unclear.…”