In vitro corrosion behavior, bioactivity, and antibacterial performance of the silver-doped zinc oxide coating on magnesium alloy

Bakhsheshi‐Rad, Hamid Reza; Hamzah, Esah; Ismail, Ahmad Fauzi; Aziz, Madzlan; Kasiri‐Asgarani, Masoud; Ghayour, Hamid; Razzaghi, Mahmood; Hadisi, Zhina

doi:10.1002/maco.201709597

Cited by 33 publications

(25 citation statements)

References 24 publications

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“…E. coli cell wall consists of lipid A, lipopolysaccharide, and peptidoglycan, while S. aureus cell wall comprises of only a simple peptidoglycan layer. [ 78,79 ] Similar finding was reported by Becheri et al [ 80 ] that ZO nanoparticles showed greater antibacterial activity on gram‐positive ( S. aureus ) than the gram‐negative ( E. coli ) bacteria. They suggested that the outer layer of gram‐positive S. aureus may facilitate ZO adhesion onto the cell wall whereas the surface of gram‐negative bacteria may repeal this adhesion.…”

Section: Resultssupporting

confidence: 78%

Hyaluronic Acid (HA)‐Based Silk Fibroin/Zinc Oxide Core–Shell Electrospun Dressing for Burn Wound Management

Hadisi

Farokhi

Bakhsheshi‐Rad

et al. 2020

Macromolecular Bioscience

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135

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Burn injuries represent a major life‐threatening event that impacts the quality of life of patients, and places enormous demands on the global healthcare systems. This study introduces the fabrication and characterization of a novel wound dressing made of core–shell hyaluronic acid–silk fibroin/zinc oxide (ZO) nanofibers for treatment of burn injuries. The core–shell configuration enables loading ZO—an antibacterial agent—in the core of nanofibers, which in return improves the sustained release of the drug and maintains its bioactivity. Successful formation of core–shell nanofibers and loading of zinc oxide are confirmed by transmission electron microscopy, Fourier‐transform infrared spectroscopy, and energy dispersive X‐ray. The antibacterial activity of the dressings are examined against Escherichia coli and Staphylococcus aureus and it is shown that addition of ZO improves the antibacterial property of the dressing in a dose‐dependent fashion. However, in vitro cytotoxicity studies show that high concentration of ZO (>3 wt%) is toxic to the cells. In vivo studies indicate that the wound dressings loaded with ZO (3 wt%) substantially improves the wound healing procedure and significantly reduces the inflammatory response at the wound site. Overall, the dressing introduced herein holds great promise for the management of burn injuries.

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Section: Resultssupporting

confidence: 78%

Hyaluronic Acid (HA)‐Based Silk Fibroin/Zinc Oxide Core–Shell Electrospun Dressing for Burn Wound Management

Hadisi

Farokhi

Bakhsheshi‐Rad

et al. 2020

Macromolecular Bioscience

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135

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“…After 14 days, corrosion product was deposited on the surface of all samples which work as barrier layer, which resulted in the pH values escalation rate is reduced. When the incubation finished, the pH value of bare Mg alloy, TaN coating and CLT coating is 10.35, 8.62 and 7.91 respectively implying lower pH value of CLT coating in comparison with the bare Mg alloy [ 8 , 10 , 19 ]. The XRD pattern of the CLT coating samples after incubation in the SBF for 14 days depicted the existence of the sharp peaks of Mg(OH) 2 as well as the small peaks of HA, along with the α-Mg peaks which is related to the matrix ( Figure 4 h).…”

Section: Resultsmentioning

confidence: 99%

“…Having said that, the high degradation rate of Mg alloys in physiological medium lessens the mechanical characteristics of implants ahead of time and generates Mg (OH) 2 and H 2 gas [8,9]. An additional issue is whether or not the Mg alloy is able to maintain mechanical characteristic and biocompatibility throughout the implantation period [10,11].…”

Section: Introductionmentioning

confidence: 99%

Clinoenstatite/Tantalum Coating for Enhancement of Biocompatibility and Corrosion Protection of Mg Alloy

Bakhsheshi‐Rad

Najafinezhad

Hamzah

et al. 2020

JFB

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Biodegradable Mg alloys have appeared as the most appealing metals for biomedical applications, particularly as temporary bone implants. However, issues regarding high corrosion rate and biocompatibility restrict their application. Hence, in the present work, nanostructured clinoenstatite (CLT, MgSiO3)/tantalum nitride (TaN) was deposited on the Mg-Ca-Zn alloy via electrophoretic deposition (EPD) along with physical vapor deposition (PVD) to improve the corrosion and biological characteristics of the Mg-Ca-Zn alloy. The TaN intermediate layer with bubble like morphology possessed a compact and homogenous structure with a thickness of about 950 nm while the thick CLT over-layer (~15 μm) displayed a less compact structure containing nano-porosities as well as nanoparticles with spherical morphology. The electrochemical tests demonstrated that the as prepared CLT/TaN film is able to substantially increase the anticorrosion property of Mg-Ca-Zn bare alloy. Cytocompatibility outcomes indicated that formation of CLT and TaN on the Mg bare alloy surface enhanced cell viability, proliferation and growth, implying excellent biocompatibility. Taken together, the CLT/TaN coating exhibits appropriate characteristic including anticorrosion property and biocompatibility in order to employ in biomedical files.

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“…Magnesium (Mg) alloys are potential biomedical implant materials for orthopedic applications on account of their unique biodegradability and excellent mechanical properties . However, the very fast degradation rate of Mg alloys greatly restricts their application . It is crucial to develop Mg alloys with satisfactory degradation resistance.…”

Section: Introductionmentioning

confidence: 99%

Mn‐promoting formation of a long‐period stacking‐ordered phase in laser‐melted Mg alloys to enhance degradation resistance

Shuai

Liu

Gao

et al. 2019

Materials & Corrosion

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Magnesium (Mg) alloys are promising candidates for use as biomedical implant materials. However, their very fast degradation rate greatly restricts their application. A rare earth phase possessed with a long‐period stacking‐ordered (LPSO) structure was in favor of enhancing the degradation resistance of Mg alloys. In fact, the formation of the LPSO phase in Mg alloys depends on their stacking fault energy. The lower the stacking fault energy, the more the LPSO phase formed. In this study, manganese (Mn) was alloyed to Mg alloy ZK30–10Gd (containing 3 wt.% Zn and 10 wt.% Gd) via selective laser melting to promote the formation of the LPSO phase. As an alloying element, Mn could be in favor of reducing stacking fault energy due to the fact that the large difference between the atomic radius of Mn and that of Mg induced large lattice distortion to facilitate forming stacking faults. The results showed that as the Mn content increased from 0 to 1.2 wt.%, the area fraction of LPSO phase increased from 12.22% to 22.37%, meanwhile the area fraction of (Mg,Zn)3Gd phase decreased from 9.31% to 2.32%. The ZK30–10Gd–0.6Mn possessed the highest degradation resistance (weight loss rate 0.38 mg · cm−2 · day−1). The enhancement of degradation resistance had two reasons. On the one hand, more LPSO phase provided more sites for nucleation of degradation products, which could promote the formation of a homogeneous and compact degradation product film to protect the Mg matrix. On the other hand, the inhibition of (Mg,Zn)3Gd phase precipitation could reduce galvanic corrosion.

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In vitro corrosion behavior, bioactivity, and antibacterial performance of the silver-doped zinc oxide coating on magnesium alloy

Cited by 33 publications

References 24 publications

Hyaluronic Acid (HA)‐Based Silk Fibroin/Zinc Oxide Core–Shell Electrospun Dressing for Burn Wound Management

Hyaluronic Acid (HA)‐Based Silk Fibroin/Zinc Oxide Core–Shell Electrospun Dressing for Burn Wound Management

Clinoenstatite/Tantalum Coating for Enhancement of Biocompatibility and Corrosion Protection of Mg Alloy

Mn‐promoting formation of a long‐period stacking‐ordered phase in laser‐melted Mg alloys to enhance degradation resistance

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