In vitro cultured calculus bovis attenuates cerebral ischaemia-reperfusion injury by inhibiting neuronal apoptosis and protecting mitochondrial function in rats

Lu, Feibiao; Wang, Lingfeng; Chen, Yanyue; Zhang, Xiaoming; Huang, Zhen

doi:10.1016/j.jep.2020.113168

Cited by 7 publications

(4 citation statements)

References 41 publications

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“…The main constituents of ICCB include taurine, cholic acid (CA), ursodeoxycholic acid (UDCA), Hyodeoxycholic acid (HDCA), deoxycholate, and bilirubin. ICCB significantly reduced the expression of Bax, Caspase‐9, Caspase‐3, and Cyt c protein, while increasing the expression of Bcl‐2, inhibiting neuronal apoptosis, and protecting mitochondrial function to reduce CIRI in rats (Lu et al, 2020). ICCB protects cerebral neurovascular units through HIF‐1/VEGF and PI3K/Akt signalling pathways (Du et al, 2022).…”

Section: Potential Mechanisms Of Tcm and Its Major Bioactive Constitu...mentioning

confidence: 99%

Traditional Chinese medicines treat ischemic stroke and their main bioactive constituents and mechanisms

Fan,

Liu,

Liu

et al. 2023

Phytotherapy Research

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Ischemic stroke (IS) remains one of the leading causes of death and disability in humans. Unfortunately, none of the treatments effectively provide functional benefits to patients with IS, although many do so by targeting different aspects of the ischemic cascade response. The advantages of traditional Chinese medicine (TCM) in preventing and treating IS are obvious in terms of early treatment and global coordination. The efficacy of TCM and its bioactive constituents has been scientifically proven over the past decades. Based on clinical trials, this article provides a review of commonly used TCM patent medicines and herbal decoctions indicated for IS. In addition, this paper also reviews the mechanisms of bioactive constituents in TCM for the treatment of IS in recent years, both domestically and internationally. A comprehensive review of preclinical and clinical studies will hopefully provide new ideas to address the threat of IS.

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Section: Potential Mechanisms Of Tcm and Its Major Bioactive Constitu...mentioning

confidence: 99%

Traditional Chinese medicines treat ischemic stroke and their main bioactive constituents and mechanisms

Fan,

Liu,

Liu

et al. 2023

Phytotherapy Research

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show abstract

“…Mitochondrial ultrastructure injury was partially improved in cerebral I/R rats after pretreatment with in vitro cultured Bos taurus domesticus Gmelin or Chrysanthemum morifolium Ramat. extracts ( Lin et al, 2010 ; Lu et al, 2020 ). Pretreatment with herbal extracts (e.g., Astragalus membranaceus (Fisch.)…”

Section: Progress In Ischemic Stroke Prevention and Treatment Using T...mentioning

confidence: 99%

“…These herbal extracts upregulated the expression of Bcl-2, mitochondrial Cyt-C (Mito-Cyt-c), cytosolic phospho-Bad (p-Bad)/Bad ratios, and mitochondrial p-Bad/Bad. Additionally, they downregulated the expression of Bax, p53, Apaf1, Bax, Bid, Cyt-c, cleaved PARP-1, and active caspase-3, -9, and -8 ( Dohare et al, 2008b ; Huang et al, 2012 ; Zhang et al, 2013 ; Wang et al, 2014 ; Ye et al, 2016 ; Cheng et al, 2017 ; Meng et al, 2018 ; Lu et al, 2020 ). Evidence from in vitro experiments has demonstrated that A. odorata Lour.…”

Section: Progress In Ischemic Stroke Prevention and Treatment Using T...mentioning

confidence: 99%

“…Similarly, Arctium lappa L. roots ameliorated OGD/R-induced injury by suppressing AMPK/mammalian target of rapamycin (mTOR)-mediated autophagy (Yang et al, 2021). and active caspase-3, -9, and -8 (Dohare et al, 2008b;Huang et al, 2012;Zhang et al, 2013;Ye et al, 2016;Cheng et al, 2017;Meng et al, 2018;Lu et al, 2020). Evidence from in vitro experiments has demonstrated that A. odorata Lour.…”

Section: Herbal Extract Pretreatment In Regulating Mitochondria Of Is...mentioning

confidence: 99%

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Traditional Chinese medicine in treating ischemic stroke by modulating mitochondria: A comprehensive overview of experimental studies

et al. 2023

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Ischemic stroke has been a prominent focus of scientific investigation owing to its high prevalence, complex pathogenesis, and difficulties in treatment. Mitochondria play an important role in cellular energy homeostasis and are involved in neuronal death following ischemic stroke. Hence, maintaining mitochondrial function is critical for neuronal survival and neurological improvement in ischemic stroke, and mitochondria are key therapeutic targets in cerebral stroke research. With the benefits of high efficacy, low cost, and high safety, traditional Chinese medicine (TCM) has great advantages in preventing and treating ischemic stroke. Accumulating studies have explored the effect of TCM in preventing and treating ischemic stroke from the perspective of regulating mitochondrial structure and function. In this review, we discuss the molecular mechanisms by which mitochondria are involved in ischemic stroke. Furthermore, we summarized the current advances in TCM in preventing and treating ischemic stroke by modulating mitochondria. We aimed to provide a new perspective and enlightenment for TCM in the prevention and treatment of ischemic stroke by modulating mitochondria.

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Danhong injection alleviates cerebral ischemia-reperfusion injury by inhibiting mitochondria-dependent apoptosis pathway and improving mitochondrial function in hyperlipidemia rats

Zhu

Zhou

et al. 2023

Biomedicine & Pharmacotherapy

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In vitro cultured calculus bovis attenuates cerebral ischaemia-reperfusion injury by inhibiting neuronal apoptosis and protecting mitochondrial function in rats

Cited by 7 publications

References 41 publications

Traditional Chinese medicines treat ischemic stroke and their main bioactive constituents and mechanisms

Traditional Chinese medicines treat ischemic stroke and their main bioactive constituents and mechanisms

Traditional Chinese medicine in treating ischemic stroke by modulating mitochondria: A comprehensive overview of experimental studies

Danhong injection alleviates cerebral ischemia-reperfusion injury by inhibiting mitochondria-dependent apoptosis pathway and improving mitochondrial function in hyperlipidemia rats

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