In vitro cytocompatibility and blood compatibility of polysulfone blend, surface-modified polysulfone and polyacrylonitrile membranes for hemodialysis

Roy, Atanu Singha; Dadhich, Prabhash; Dhara, Santanu; De, Sirshendu

doi:10.1039/c4ra13460e

Cited by 46 publications

(33 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, A3 demonstrated greater thromboresistance than A1 or A2 (Figure 2), suggesting that hydrophilicity and thromboresistance are directly related. Our observations are similar to other those of other researchers, who have demonstrated a decrease in protein adsorption [8][9][10][11]33] and platelet activation with an increase in material hydrophilicity. Our observations are similar to other those of other researchers, who have demonstrated a decrease in protein adsorption [8][9][10][11]33] and platelet activation with an increase in material hydrophilicity.…”

Section: Clotting Time Measurementsupporting

confidence: 92%

Hydrophilic films: How hydrophilicity affects blood compatibility and cellular compatibility

Kuo

Fang²,

Wu³

et al. 2017

Adv Polym Technol

View full text Add to dashboard Cite

Hydrophilic materials have been used in many fields, but have recently garnered growing attention in biomedicine. To promote the development and use of suitable hydrophilic materials for biomedical applications, we used three hydrophilic films of varying hydrophilicity and examined the effects of their hydrophilicity on blood compatibility, protein adsorption, blood clotting time, hemolytic activity, biocompatibility, and cell attachment. Across the spectrum of hydrophilicity examined, no obvious differences in biocompatibility were observed. While high material hydrophilicity was associated with higher hemolytic activity, it still fit the nonhemolytic criteria. Further, higher hydrophilicity decreased protein adsorption and cell attachment, but increased thromboresistance in our blood clotting time assay (~30% higher blood clotting index at 10 min). These results indicate that hydrophilicity increases blood compatibility with regard to thromboresistance, but reduces cellular compatibility (i.e., cell attachment), characteristics that could be exploited for a wide range of potential applications in various fields, such as glucose electrode test strips.

show abstract

Section: Clotting Time Measurementsupporting

confidence: 92%

Hydrophilic films: How hydrophilicity affects blood compatibility and cellular compatibility

Kuo

Fang²,

Wu³

et al. 2017

Adv Polym Technol

View full text Add to dashboard Cite

show abstract

“…Zavastin et al 31 reported the successful application of PU/CA blend membranes in wastewater treatment in the textile industry. [34][35][36] In addition, better antifouling and antithrombotic properties using PES/PU composite membranes during dialysis was carried out by Yin et al 37 A recent report by Roy et al 38 showed that a PSF/PVP/PEG blend membrane was found to have adequate cyctocompatibility and blood compatibility for hemodialysis. The ux and protein rejection were increased for the blend ultraltration (UF) membranes with dimethylacetamide (DMAc) when compared to dimethylformamide (DMF) as a solvent.…”

Section: Introductionmentioning

confidence: 99%

Preparation, characterization and antifouling properties of polyacrylonitrile/polyurethane blend membranes for water purification

Panda

2015

RSC Adv.

Self Cite

View full text Add to dashboard Cite

Casting of flat sheet polyacrylonitrile (PAN)/polyurethane (PU) blend membranes was reported for the first time in this work. PU makes the membrane more porous. Ternary phase diagram indicates that the addition of PU increases the thermodynamic instability of the blend. The average pore size of the membrane increased from 11 nm to 18 nm for pure PAN and the PAN/PU blend membranes. The membranes were characterized in terms of permeability, porosity, molecular weight cut-off (MWCO), contact angle, mechanical strength, scanning electron microscope (SEM), atomic force microscope (AFM), differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR). The AFM images indicated that the surface roughness of the membrane increased with an increase in the concentration of PU. Addition of PU also imparted hydrophilicity to the membranes. FTIR and DSC measurements confirm the polymer compatibility of the PAN/PU blend. The PAN/PU blend 70/30 membrane exhibited the maximum antifouling characteristics with a 99% flux recovery ratio associated with the complete removal of turbidities and organic matter.

show abstract

“…To reduce the problem of initial fouling different approaches for surface hydrophilization have been investigated such as copolymerization or grafting with hydrophilic monomers [8][9][10][11][12][13][14], blending using hydrophilic polymers [15][16][17][18][19][20], and, finally, chemical modification of the membrane polymer [21].…”

Section: Polymers 2015 7mentioning

confidence: 99%

Biocatalytic Self-Cleaning Polymer Membranes

et al. 2015

View full text Add to dashboard Cite

Polymer membrane surfaces have been equipped with the digestive enzyme trypsin. Enzyme immobilization was performed by electron beam irradiation in aqueous media within a one-step method. Using this method, trypsin was covalently and side-unspecific attached to the membrane surface. Thus, the use of preceding polymer functionalization and the use of toxic solvents or reagents can be avoided. The resulting membranes showed significantly improved antifouling properties as demonstrated by repeated filtration of protein solutions. Furthermore, the biocatalytic membrane can be simply "switched on" to actively degrade a fouling layer on the membrane surface and regain the initial permeability. The membrane pore structure (pore size and porosity) was neither damaged by the electron beam treatment nor blocked by the enzyme loading, ensuring a stable membrane performance.

show abstract

In vitro cytocompatibility and blood compatibility of polysulfone blend, surface-modified polysulfone and polyacrylonitrile membranes for hemodialysis

Abstract: Three different formulations of dialysis grade membranes and their physiological, cyto- and hemocompatibility have been presented.

Cited by 46 publications

References 46 publications

Hydrophilic films: How hydrophilicity affects blood compatibility and cellular compatibility

Hydrophilic films: How hydrophilicity affects blood compatibility and cellular compatibility

Preparation, characterization and antifouling properties of polyacrylonitrile/polyurethane blend membranes for water purification

Biocatalytic Self-Cleaning Polymer Membranes

Contact Info

Product

Resources

About