2004
DOI: 10.1016/j.jep.2003.09.014
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In vitro cytotoxic activity of Thai medicinal plants used traditionally to treat cancer

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Cited by 223 publications
(174 citation statements)
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“…Breast cancer (MCF-7) and cervical cancer were used in the present study in vitro. Cytotoxicity was done according to the method of Itharat, et al [51]. IC50 was calculated by analysis between surviving fraction and concentration [52].…”
Section: Cytotoxicity and Anticancer Activity In Vitromentioning
confidence: 99%
See 1 more Smart Citation
“…Breast cancer (MCF-7) and cervical cancer were used in the present study in vitro. Cytotoxicity was done according to the method of Itharat, et al [51]. IC50 was calculated by analysis between surviving fraction and concentration [52].…”
Section: Cytotoxicity and Anticancer Activity In Vitromentioning
confidence: 99%
“…It can be observed that L-asparaginase inhibits cell proliferation of HEPG2 and HCT-116 (human cancer cell lines) that could arrest the cell cycle and generate apoptosis, which explain the in vitro anti-proliferative effect of L-asparaginase. Cancer cells exhibit rapid growth and cell division, and therefore have an increased nutritional need than normal cell [23,51]. In most human cells deficiency, L-asparagine is produced from aspartic acid and glutamine by asparagine synthetase.…”
Section: Cytotoxicity and Anticancer Activity Ofl-aspargenasementioning
confidence: 99%
“…Conforme os critérios estabelecidos pelo Instituto Nacional Americano de Câncer (INC), a citotoxicidade de extratos brutos em ensaios preliminares deve apresentar o limite máximo de IC 50 de 30 µg/mL para ser considerado promissor para purificação e emprego como antineoplásico (Suffness & Pezzuto, 1990;Itharata et al, 2004;Alzeer et al, 2014). Desta forma, os extratos clorofórmico e hexânico de E. anomala apresentaram citotoxicidade muito interessante e promissora, pois o IC 50 encontrado para ambos (25,56 e 31,25 µg/mL, respectivamente) esteve próximo ao estabelecido para o emprego como antineoplásico.…”
Section: Citotoxicidade In Vitro Dos Extratosunclassified
“…[7] In fact, the medicinal plants are easily available, cheaper and possess less toxicity as compared to the modern allopathic drugs. [8,9] Phytoconstituents promotes and strengthens digestion. It also rejuvenates the body tissues & controls the metabolic activities of the body.…”
Section: World Journal Of Pharmacy and Pharmaceutical Sciencesmentioning
confidence: 99%