In vitro cytotoxic activity of rhizome extracts of Cyperus rotundus (L.) against colon carcinoma and Ehrlich ascites carcinoma

Nidugala, Hema; Avadhani, Ramakrishna; Prabhu, Ashwini; Ravishankar, B

doi:10.7324/japs.2016.601127

Cited by 5 publications

(1 citation statement)

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“…Cyperus rotundus L. is known to have cytotoxic effects on some cancer cells, such as leukemia cells K562 and L1210 [4], lymphoma cells of L5178 mice [5], HeLa cells and SiHa cells in cervical cancer [6], Ehrlich's ascites carcinoma breast cancer [7], and KB oral cancer [8].The essential oil potent cytotoxic activities against colon (HCT-116), hepatocellular (Hep G-2) and breast (MCF-7) human cancer cell lines with IC 50 of 1.06, 1.17 and 2.22 μg/mL, respectively [3]. Therefore this study is to prove whether the rhizome of Cyperus roundus L.fractionated with nhexane has the potential as a breast anticancer performed by cytotoxic testing, selectivity index (IS), induction apoptosis in MCF-7 cells.…”

Section: Introductionmentioning

confidence: 99%

Activity Anticancer n-hexane Fraction of Cyperus Rotundus l. Rhizome to Breast Cancer MCF-7 Cell Line

Simorangkir

Masfria

Harahap

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: Cancer is one of the causes of morbidity and mortality worldwide. Breast cancer is one of the most common types of cancer in Indonesia. Failures that often occur in the treatment of cancer primarily through chemotherapy, synthetic drugs that have side effects include anemia, alopecia, cardiotoxic and hepatotoxic due to low anti-cancer selectivity and unclear carcinogenesis process. Cyperus rotundus L. rhizome is one of the medicinal plants that potential enough to be developed as an anticancer agent. AIM: The aim of this study was to anticancer activity n-hexane fraction Cyperus rotundus L. rhizomes to breast cancer MCF-7 cell line in vitro. METHODS: Cyperus rutundus L. rhizomes powder was extracted ethanol by percolation then fractionated with n-hexane. Phytochemical screening was then carried out. The cytotoxic activity of the n-hexane fraction was determined by observing this extract on MCF-7 cells using the (3- (4,5-dimethylimidazole-2-il) -2,5-diphenyl tetrazolium bromide) (MTT). Selectivity index (IS) of normal cells (Vero cells). Cell cycle and apoptosis induction were analyzed by flow cytometry. RESULTS: The result showed that the fraction n-hexane Cyperus rutundus L. rhizome has anticancer activity against breast cancer MCF-7 cells with accumulation cell cycle in the G0-G1 phase and through induction of apoptosis. CONCLUSION: The n-hexane fraction Cyperus rotundus L. rhizome has potent anticancer activity.

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Section: Introductionmentioning

confidence: 99%