In Vitro Cytotoxic Activity Toward Anticancer and Antimicrobial of <i>Azadirachta Indica</i>, <i>Aegle Marmelos</i>, <i>Ocimum Sanctum</i> and <i>Withania Somnifera</i> Extracts

Abstract

Background: Resistance to treatment represents the 'big' problem and the considerable improvement in survival rates still remains a researcher's dream. Thus, continued research efforts are required to make treatments more personalized, to minimize side effects and improve overall survival and to also have an insight in toxico-genomics. Indeed proof of facts about medicinal plants worldwide and rich Indian medicinal flora, Objective: in the present investigation attempts to evaluate antimicrobials and anticancer therapeutic properties of isolated constituents from Withania somnifera (ASHWANGANDHA) Part Used Leaves, Aegle marmeleos (BEL) Part Used Leaves, Azadirachta indica (NEEM) Part Used Leaves, Ocimum sanctum (TULASI) Part Used Leaves, Method: Hydro alcoholic (1:1) Extracts were evaluated against cancer cell lines i.e. A549 (Lung carcinoma), PA-1 (Ovarian cancer) and MCF-7 (Breast cancer), with standard as Doxorubicin. Moreover the antimicrobial activity on Staphylococcus aureus, Bacillus coagulans and one Gram-negative-Escherichia coli, human pathogenic bacteria; and three fungal strains-Aspergillus niger, Tricoderma viride and Fusarium oxysporum. Result: The results showed significant association of phytochemicals on inhibition of test bacteria and fungi with significant p value p< 0.05, except For Tricoderma viride No Association Was Found P>0.05.