In vitro cytotoxic and toxicological activities of ethanolic extract of Kaempferia galanga Linn. and its active component, ethyl-p-methoxycinnamate, against cholangiocarcinoma

Tritripmongkol, Porwornwisit; Plengsuriyakarn, Tullayakorn; Tarasuk, Mayuri; Na‐Bangchang, Kesara

doi:10.1016/j.joim.2020.04.002

Cited by 8 publications

(6 citation statements)

References 28 publications

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“…Nees. The previously reported studies of various potential herbs (extracts or isolated compounds/synthelic analogs) for CCA focused on their antiproliferative activities against CCA cell lines or antitumor activities in animal models, activities on cell invasion and migration, and underlying mechanisms or targets of their actions 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , …”

Section: Resultsmentioning

confidence: 99%

“…DC., G. hanburyi Hook.f., and Piper nigrum L. (Piperaceae) are classified as potent 5 , 6 , 7 , while those of Dioscorea membranacea Pierre ex Prain & Burkill (Dioscoreaceae), Kaempferia galanga L. (Zingiberaceae), Mesua ferrea L. (Calophyllaceae), Piper chaba Hunt. (Piperaceae), Z. officinale Roscoe, and Pra-Sa-Prao-Yhai formulation are classified as moderate 5 , 8 , 9 , 10 , 11 , and that of sho-saiko-to is classified as weak activity 12 . For the isolated compounds/synthetic analogs, those with the most potent activity are cucurbitacin B and triptolide [from T. wilfordii Hook.…”

Section: Resultsmentioning

confidence: 99%

“…Possible molecular mechanisms of these herbs and/or isolated compounds/synthetic analogs on CCA cells involve induction of apoptosis, autophagy, and cell cycle arrest (at G 0 /G 1 , G 1 , G 1 /S, or G 2 /M phases) through suppression of proinflammatory cytokines and growth factors (IL6, EGF, VEGF, etc.) 10 , 13 , 23 , 27 , 28 , 29 , 30 , 32 , 34 , 36 , 41 , 43 , 46 , 51 , 52 , 53 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , suppression of expression of cell surface receptors ( Vegfr2 , EGFR peroxisome proliferator-activated receptor gamma, DR4 and DR5, and TRAIL) 69 , 86 , 87 , 88 , and deregulation of intracellular pathways (JAK/STAT3, RAS/MAPK, PI3K/AKT, GSK β / β -catenin, NF κ B/AMPK, ERK, p38/MAPK, HO1, ROS/JNK, EGFR, VEGF, COX2, FAK, MMP2, MMP9, ICAM1, caspase-3, -8, and − 9, TR1, MDR1, MRP1, 2, and 3, TRAF1, XIAP, p21, p53, p65, and CHOP dependent) ( Fig. 2 ) 7 , 11 , 16 , 19 ,…”

Section: Resultsmentioning

confidence: 99%

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The Role of Herbal Medicine in Cholangiocarcinoma Control: A Systematic Review

2022

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The growing incidence of cholangiocarcinoma (bile duct cancer) and limited treatment options stimulate a pressing demand for research and the development of new chemotherapeutics against cholangiocarcinoma. This study aimed to systematically review herbs and herb-derived compounds or herbal formulations that have been investigated for their anti-cholangiocarcinoma potential. Systematic literature searches were conducted in three electronic databases: PubMed, ScienceDirect, and Scopus. One hundred and twenty-three research articles fulfilled the eligibility critera and were included in the analysis (68 herbs, isolated compounds and/or synthetic analogs, 9 herbal formulations, and 119 compounds that are commonly found in several plant species). The most investigated herbs were Atractylodes lancea (Thunb.) DC. (Compositae) and Curcuma longa L. (Zingiberaceae). Only A. lancea (Thunb.) DC. (Compositae) has undergone the full process of nonclinical and clinical development to deliver the final product for clinical use. The extracts of A. lancea (Thunb.) DC. (Compositae), Garcinia hanburyi Hook.f. (Clusiaceae), and Piper nigrum L. (Piperaceae) exhibit antiproliferative activities against human cholangiocarcinoma cells (IC50 < 15 µg/mL). Cucurbitacin B and triptolide are herbal isolated compounds that exhibit the most promising activities (IC50 < 1 µM). A series of experimental studies (in vitro, in vivo, and humans) confirmed the anti-cholangiocarcinoma potential and safety profile of A. lancea (Thunb.) DC. (Compositae) and its active compounds atractylodin and β-eudesmol, including the capsule pharmaceutical of the standardized A. lancea (Thunb.) DC. (Compositae) extract. Future research should be focused on the full development of the candidate herbs to deliver products that are safe and effective for cholangiocarcinoma control.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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The Role of Herbal Medicine in Cholangiocarcinoma Control: A Systematic Review

2022

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“…The majority of iCCA cases require extended liver resection [ 26 ] but recurrence rates after resection are high, reaching 60–65% [ 6 ] at a median of 18 months [ 27 ] with risk factors for recurrence being metastases to lymph nodes, vascular invasion, multifocal iCCA, low histologic grading and size of the tumor [ 28 ]. Studies have identified several herbs and formulas that exhibit potential anti-tumor effects against iCCA, including Curcuma wenyujin, Salvia miltiorrhiza, Bufei Yishen formula and Jianpi Huaji formula; these herbs and formulas have been shown to inhibit cancer cell proliferation, induce apoptosis, and regulate immune function [ 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

Role of Percutaneous Ablation in the Management of Intrahepatic Cholangiocarcinoma

et al. 2023

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Cholangiocarcinoma (CCA) is an invasive cancer accounting for <1% of all cancers and 10–15% of primary liver cancers. Intrahepatic CCA (iCCA) is associated with poor survival rates and high post-surgical recurrence rates whilst most diagnosed patients are not surgical candidates. There is a growing literature suggesting percutaneous ablative techniques for the management of patients with iCCA measuring ≤3 cm with contraindications to surgery as well as for recurrent or residual tumors aiming to provide local cancer treatment and control. Most used ablative therapies for iCCA include radiofrequency and microwave ablation with irreversible electroporation, cryoablation and reversible electroporation (electrochemotherapy) being less commonly encountered techniques. Due to the infiltrative margins of the lesion, there is a need for larger safety margins and ablation zone; multi-apparatus ablation or other variations of the technique such as balloon-assisted approaches can be utilized aiming to increase size of the zone of necrosis. The present review paper focuses upon the current role of percutaneous ablative techniques for the therapeutic management of iCCA. The purpose of this review is to present the current minimally invasive ablative techniques in the treatment of iCCA, including local control and survival rates.

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“…Several studies have applied traditional methods such as solvent extraction [2], maceration [7], and Soxhlet [9] to extract the KGL essential oils (EOs). These techniques utilize organic solvents such as hexane, DMSO and ethanol have created safety issues due to their hazardous, flammable, and potentially toxic for food and pharmaceutical applications.…”

Section: Introductionmentioning

confidence: 99%

Comparison of different methods for the extraction of essential oil from the rhizome part of Kaempferia galanga linn

Nurhaslina

Mustapa

Azizi

et al. 2022

IOP Conf. Ser.: Mater. Sci. Eng.

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Kaempferia galanga linn (KGL) is a well-known condiment in Southeast Asia, consisting of huge advantages for health sustainability. This research aims to compare the essential oils (EOs) yield of the KGL rhizome utilising modern technologies – solvent-free microwave extraction (SFME) and microwave-assisted extraction (MAE) to the traditional method of hydrodistillation (HD). The influence of process parameters on the oil yield is determined and the composition of the extracts is characterised using Gas Chromatography-Mass Spectrometer (GCMS). The SFME has been demonstrated as the most excellent method in producing substantially high yield in a shorter time (40 min, 2.54 %) in comparison to the MAE (40 min, 1.03%) and HD (3 h, 0.14%). Ethyl p-methoxycinnamate from the class of cinnamic acid ester appears as the main volatile constituent with a percent content of 11.6%, 10%, and 13.4% obtained by SFME, MAE, and HD, respectively. The SEM analysis of the KGL reveals that microwave technology caused a significant plant cell wall rupture, thus promoting faster oil extraction than the traditional extraction approach. This study demonstrates that SFME is a promising alternative to producing essential oil as natural products without solvent, safer for pharmaceutical and food industries.

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In vitro cytotoxic and toxicological activities of ethanolic extract of Kaempferia galanga Linn. and its active component, ethyl-p-methoxycinnamate, against cholangiocarcinoma

Cited by 8 publications

References 28 publications

The Role of Herbal Medicine in Cholangiocarcinoma Control: A Systematic Review

The Role of Herbal Medicine in Cholangiocarcinoma Control: A Systematic Review

Role of Percutaneous Ablation in the Management of Intrahepatic Cholangiocarcinoma

Comparison of different methods for the extraction of essential oil from the rhizome part of Kaempferia galanga linn

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