In Vitro Cytotoxic Assessment of Functionalized Multi-walled Carbon Nanotubes Against Cervical Cancer

Chaturvedi, Vivek K.; Tripathi, Abhay Dev; Minocha, Tarun; Singh, Vivek; Singh, Mohan; Yadav, Dhananjay

doi:10.1007/s10876-023-02450-7

Cited by 3 publications

(3 citation statements)

References 48 publications

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“…The XRD of f -MWCNTs showed characteristic peaks at 2θ = 25.63° (002), 43.44° (100), and 53.26° (004), consistent with the crystalline structure of multiwalled carbon nanotubes. 55 , 56 In the XRD spectrum of PANI-CoPc-fur -f -MWCNTs nanoconjugate, analogous peaks to those of f -MWCNTs were found but with reduced intensities which support the nanoconjugation of PANI-CoPc. 57 In the XRD spectrum of ENFs- 2 , a single peak at 19.53° (011) was observed which is attributed to the semicrystalline PVA.…”

Section: Resultsmentioning

confidence: 87%

Electrospun Nanofiber Composite Utilized as an Electrocatalyst for the Detection of Acetaminophen in Multifarious Water Samples

Shoba,

Mambanda,

Booysen

2024

ACS Omega

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Herein, the nanofabrication and characterization of new conductive materials, PANI-CoPc-fur (1) ((PANI = polyaniline and CoPc-fur = tetra-4-(furan-2-methylthiophthalocyaninato)-Co(II)) and PANI-CoPc-fur-f-MWCNTs (2) ( f-MWCNTs = carboxylic acid-functionalized multiwalled carbon nanotubes), are reported. Subsequently, an electrospun nanofiber (ENF) composite of 2, encapsulated with a poly(vinyl acetate) shell, was fabricated. The resultant core−shell nanoconjugated fibers, ENFs-2, were adsorbed on a glassy carbon electrode (GCE), followed by the immobilization of a permeable adhesion top layer of Nafion (Nf) to render the chemically modified electrode, GCE|ENFs-2-Nf. The electron-mediating properties of the components within the film of GCE|ENFs-2-Nf synergistically aided in promoting its electrocatalytic activities. Consequently, the CME showed greater cyclic voltammetry (CV) peak currents compared to the bare GCE and other modified electrodes, indicating its higher sensitivity toward acetaminophen (APAP), an emerging water pollutant of concern. The detection of APAP at the GCE|ENFs-2-Nf attained by square-wave voltammetry (SWV) was linear from 10 to 200 μM of APAP and was reproducible (%RSD of 3.2%, N = 3). The respective calculated limits of detection and quantification (LOD and LOQ) values of 0.094 and 0.28 μM were lower than those acquired using other electrochemical techniques. Analysis of APAP in the presence of commonly associated interferences metronidazole (MTZ) and dopamine (DA) illustrated a significant separation between the SWV peak potentials of APAP and MTZ, whereas there was some degree of overlap between the SWV current responses of APAP and DA. The analytical performance of the GCE|ENFs-2-Nf rendered a comparable percentage recovery (104%) with that of liquid chromatography−mass spectrometry (LC−MS) (106%).

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Section: Resultsmentioning

confidence: 87%

Electrospun Nanofiber Composite Utilized as an Electrocatalyst for the Detection of Acetaminophen in Multifarious Water Samples

Shoba,

Mambanda,

Booysen

2024

ACS Omega

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“…DLS (dynamic light scattering) and TEM (transmission electron microscopy) imaging techniques were employed to analyze size and morphology . Malvern Zetasizer (Nano ZS U.K.) instrument measured the zeta potential, particle’s hydrodynamic size, and PDI.…”

Section: Methodsmentioning

confidence: 99%

“…DLS (dynamic light scattering) and TEM (transmission electron microscopy) imaging techniques were employed to analyze size and morphology. 35 Malvern Zetasizer (Nano ZS U.K.) instrument measured the zeta potential, particle's hydrodynamic size, and PDI. DLS assessment was executed using a material refractive index (RI) of 1.54 with a dispersant RI of 1.330 and temperature set at 25 °C.…”

Section: Synthesis Of Mesoporous Silicamentioning

confidence: 99%

Folate-Mediated Targeting and Controlled Release: PLGA-Encapsulated Mesoporous Silica Nanoparticles Delivering Capecitabine to Pancreatic Tumor

Tripathi,

Labh,

Katiyar

et al. 2024

ACS Appl. Bio Mater.

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The discovery of specifically tailored therapeutic delivery systems has sparked the interest of pharmaceutical researchers considering improved therapeutic effectiveness and fewer adverse effects. The current study concentrates on the design and characterization of PLGA (polylactic-co-glycolic acid) capped mesoporous silica nanoparticles (MSN)-based systems for drug delivery for pH-sensitive controlled drug release in order to achieve a targeted drug release inside the acidic tumor microenvironment. The physicochemical properties of the nanoformulations were analyzed using TEM, zeta potential, AFM, TGA, FTIR, and BET analyses in addition to DLS size. The final formed PLGA-FoA-MSN-CAP and pure MSN had sizes within the therapeutic ranges of 164.5 ± 1.8 and 110.7 ± 2.2, respectively. Morphological characterization (TEM and AFM) and elemental analysis (FTIR and XPS) confirmed the proper capping and tagging of PLGA and folic acid (FoA). The PLGA-coated FoA-MSN exhibited a pHdependent controlled release of the CAP (capecitabine) drug, showing efficient release at pH 6.8. Furthermore, the in vitro MTT test on PANC1 and MIAPaCa-2 resulted in an IC 50 value of 146.37 μg/ml and 105.90 μg/ml, respectively. Mitochondrial-mediated apoptosis was confirmed from the caspase-3 and annexin V/PI flow cytometry assay, which displayed a cell cycle arrest at the G1 phase. Overall, the results predicted that the designed nanoformulation is a potential therapeutic agent in treating pancreatic cancer.

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Advanced smart nanomaterial-based system for treatment of cervical cancer: A systematic review

Bhattacharjee,

Kuppusamy,

Ghose Bishwas

et al. 2024

Journal of Drug Delivery Science and Technology

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In Vitro Cytotoxic Assessment of Functionalized Multi-walled Carbon Nanotubes Against Cervical Cancer

Cited by 3 publications

References 48 publications

Electrospun Nanofiber Composite Utilized as an Electrocatalyst for the Detection of Acetaminophen in Multifarious Water Samples

Electrospun Nanofiber Composite Utilized as an Electrocatalyst for the Detection of Acetaminophen in Multifarious Water Samples

Folate-Mediated Targeting and Controlled Release: PLGA-Encapsulated Mesoporous Silica Nanoparticles Delivering Capecitabine to Pancreatic Tumor

Advanced smart nanomaterial-based system for treatment of cervical cancer: A systematic review

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