In vitro cytotoxicity, corrosion and antibacterial efficiencies of Zn doped hydroxyapatite coated Ti based implant materials

Buyuksungur, Senem; Huri, Pınar Yılgör; Schmidt, Jürgen; Pană, Iulian; Dinu, Mihaela; Vițelaru, Cătălin; Kiss, A.; Tamay, Dilara Goksu; Hasırcı, Vasıf; Vlădescu, Alina; Hasırcı, Nesrin

doi:10.1016/j.ceramint.2022.12.119

Cited by 15 publications

(5 citation statements)

References 49 publications

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“…The degree of crystallisation of the HAp phase in the near‐surface area, just below the Zn particles, is also very important in terms of quality of the HAp and Zn binding. Literature data reports that the better antibacterial effect is found for Zn 2+ by replacing Ca 2+ in the HAp molecule 24 …”

Section: Resultsmentioning

confidence: 99%

“…Literature data reports that the better antibacterial effect is found for Zn 2+ by replacing Ca 2+ in the HAp molecule. 24 Qualitative analysis of the chemical composition by EDS of the boundary between the Zn particle and HAp (crystalline structure) showed diffusion over a short distance of Zn into the HAp region. On the intensity distribution map of selected elements, a thin Zn stripe is visible in the HAp area.…”

Section: F I G U R E 1mentioning

confidence: 99%

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Microstructural and micromechanical characteristics of composite osteoconductive coatings deposited by the atmospheric pressure plasma technique

Major,

Kopp,

Major

et al. 2024

Journal of Microscopy

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Long‐term placement of facial implants requires avoiding the formation of fibrous tissue capsules around the artificial material by creating osteoconductive properties of the surface. Most promising approach is the deposition coatings made of materials very similar to bone mineral components, that is, calcium phosphates such as hydroxyapatite (HAp). As part of the research work, an innovative, cost‐effective atmospheric pressure plasma deposition (APPD) system was used as a low‐temperature coating technology for generating the HAp coatings deposition. Full microstructural characterisation of the coatings using SEM and TEM techniques was carried out in the work. It has been shown that the fully crystalline HAp powder undergoes a transformation during the coatings deposition and the material had a quasi‐sintered structure after deposition. The crystalline phase content increased at the coating/substrate interface, while the surface of the HAp was amorphous. This is a very beneficial phenomenon due to the process of bioresorption. The amorphous phase undergoes much faster biodegradation than the crystalline one. In order to increase the bioactivity of the HAp, Zn particles were introduced on the surface of the coating. The TEM microstructural analysis in conjunction with the qualitative analysis of the EDS chemical composition showed that the binding of the Zn particles within the HAp matrix had diffusive character, which is very favourable from the point of view of the quality of the adhesion and the bioactivity of the coating. In the case of such a complex structure and due to its very porous nature, micromechanical analysis was carried out in situ in SEM, that is, by microhardness measurements of both the HAp matrix and the Zn particle. It was shown that the average value of HAp microhardness was 4.395 GPa ± 0.08, while the average value of Zn microhardness was 1.142 GPa ± 0.02

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Section: Resultsmentioning

confidence: 99%

Section: F I G U R E 1mentioning

confidence: 99%

Microstructural and micromechanical characteristics of composite osteoconductive coatings deposited by the atmospheric pressure plasma technique

Major,

Kopp,

Major

et al. 2024

Journal of Microscopy

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“…We can only estimate the level of proliferation, which certainly increased after 3 h of deposition. Other researchers have provided the results of in vitro experiments and proved that sputtered hydroxyapatite coatings increase cell viability [22]. Despite the in vitro tests, one cannot claim that the increase in deposition time allowed for a boost in the number of viable cells, as some of them could have died.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Surface Structure and Properties of Hydroxyapatite Coatings on NiTi Substrates

et al. 2023

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Hydroxyapatite coatings were deposited for 1, 2, and 3 h on NiTi substrates using plasma-assisted radio frequency sputtering. The matrix consisted of NiTi B2 and NiTi B19’ phases and Ti2Ni, Ni3Ti, and Ni4Ti3 intermetallic compounds. The surface coating was monoclinic hydroxyapatite. Increasing the deposition time to 3 h made it possible to form a dense hydroxyapatite layer without visible defects. The phase contrast maps showed that the coating consisted of round grains of different fractions, with the smallest grains in the sample deposited for 3 h. The wettability tests showed that the coating deposited for 3 h had the highest surface energy, reflected in the proliferation density of the MCF-7 cell line.

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“…The latest reports show that the presence of Zn in ceramic materials provides antimicrobial activity, depending on the concentrations of the doping material. Buyuksungur et al reported that a small concentration of Zn in the structure of HA is sufficient to ensure resistance against S. aureus, K. pneumoniae, or B. cereus [138]. Comparable results were also mentioned by Ofudje et al, who Zn-doped HA, which was prepared using the chemical co-precipitation method and further used as a scaffold.…”

Section: Doped Hydroxyapatite: Doping Materials and Methods Synthesis...mentioning

confidence: 93%

Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering

Radulescu,

Vasile,

Andronescu

et al. 2023

IJMS

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Bone tissue engineering has attracted great interest in the last few years, as the frequency of tissue-damaging or degenerative diseases has increased exponentially. To obtain an ideal treatment solution, researchers have focused on the development of optimum biomaterials to be applied for the enhancement of bioactivity and the regeneration process, which are necessary to support the proper healing process of osseous tissues. In this regard, hydroxyapatite (HA) has been the most widely used material in the biomedical field due to its great biocompatibility and similarity with the native apatite from the human bone. However, HA still presents some deficiencies related to its mechanical properties, which are essential for HA to be applied in load-bearing applications. Bioactivity is another vital property of HA and is necessary to further improve regeneration and antibacterial activity. These drawbacks can be solved by doping the material with trace elements, adapting the properties of the material, and, finally, sustaining bone regeneration without the occurrence of implant failure. Considering these aspects, in this review, we have presented some general information about HA properties, synthesis methods, applications, and the necessity for the addition of doping ions into its structure. Also, we have presented their influence on the properties of HA, as well as the latest applications of doped materials in the biomedical field.

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In vitro cytotoxicity, corrosion and antibacterial efficiencies of Zn doped hydroxyapatite coated Ti based implant materials

Cited by 15 publications

References 49 publications

Microstructural and micromechanical characteristics of composite osteoconductive coatings deposited by the atmospheric pressure plasma technique

Microstructural and micromechanical characteristics of composite osteoconductive coatings deposited by the atmospheric pressure plasma technique

Surface Structure and Properties of Hydroxyapatite Coatings on NiTi Substrates

Latest Research of Doped Hydroxyapatite for Bone Tissue Engineering

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