In vitro cytotoxicity evaluation of some substituted isatin derivatives

Crystal structure of 5-methoxy-N′-[(3Z)-1-benzyl-5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene]-1H-indole-2-carbohydrazide-DMSO (1/1), C27H25FN4O4S

“…Isatin (1H-indol-2,3-dione) is an endogenous compound recognized in many organisms and it exhibited a broad spectrum of pharmacological activities [1][2][3][4]. Therefore, it has been extensively utilized for the construction of a variety of compounds showing diverse biological activities [5].…”

Recent Highlights in the Development of Isatin-Based Anticancer Agents

“…decreasing the IC 50 by 145 μM) over a 24 h period. Furthermore, halogenation yielded the most active compounds, with 5-bromo-, 5-iodo-, and 5-fluoroisatin (3a, 3e and 3d respectively) being 5-10 times more active than the unsubstituted parent compound [39]. Increasing the number of electron-withdrawing groups on the ring to make combinations of dibromo-, tribromo-, iodo-and nitroisatin derivatives (3h-n) also enhanced the overall activity against a panel of human cancer cell lines, by up to 100-fold from that of the parent molecule (1).…”

Synthesis and spectroscopic analysis of Schiff Bases of Imesatin and Isatin derivatives

“…The synthetic versatility of Isatin has led to the wide applications of this compound in organic synthesis with medical and pharmacological properties of its derivatives extensively studied (Da Silva et al, 2001). A number of Schiff bases derived from Isatin and Imesatin derivatives have been reported with various biological properties such as, antimicrobial (Bari et al, 2008;Kumar et al, 2010;Chaluvaraju and Zaranappa, 2011), Central nervous system (CNS) depressant (Pandeya and Raja, 2002;Singh et al,2004;Smitha et al, 2008), anti-HIV (Teitz et al, 1994;Pandeya et al, 1998;Pandeya et al, 1999), anti-inflammatory (Khan et al, 2006;Babu et al, 2010;Panneerselvam et al, 2010), analgesic (Reddy, 2008) and as anticancer agents (Vine et al, 2007;Aboul-Fadi et al, 2012). These class of compounds have also been variously applied in a number of other applications such as, identification, detection and determination of aldehydes or ketones; purification of carbonyl or amino compounds and for protection of these groups during complex or sensitive reactions (Raman et al, 2007).…”