In vitro cytotoxicity of sera of paralysed ostriches showing serological positivity for Borna disease virus

One of the major limitations of current methods of biological detection of exposure to hazardous environmental agents is their inability to detect long-term exposures. In the current study we examined the potential of a new bioassay based on the hypothesis that serum of exposed individuals contains a toxic factor(s) produced by an affected cell/tissue. The procedure included exposure of neuronal PC12 cell cultures to sera of rats treated once with the organophosphate chlorpyrifos. Samples taken 4 weeks after chlorpyrifos exposure reduced nerve growth factor (NGF)-induced neurite outgrowth by 40%. This effect lasted 6 weeks after treatment, whereas motor activity and cholinesterase activity returned to normal levels within 1 week. These results demonstrate the potential of the proposed method to detect environmental exposures long after they have occurred.

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Toxic serum factor long after single exposure to organophosphate; a new approach for biomonitoring

Berman

Wormser

Brodsky

2005

Arch Toxicol

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High-molecular weight serum cytotoxic factor in rats treated with triphenyl phosphite: an approach for biological monitoring

Wormser

Raibstein

Kritzler

et al. 1998

Journal of Pharmacological and Toxicological Methods

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A New Approach for Evaluation of Human Exposure to Environmental Hazardous Agents

Wormser

Shatz

Furth

1997

Journal of Occupational & Environmental Medicine

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In vitro cytotoxicity of sera of paralysed ostriches showing serological positivity for Borna disease virus

Cited by 3 publications

References 4 publications

Toxic serum factor long after single exposure to organophosphate; a new approach for biomonitoring

Toxic serum factor long after single exposure to organophosphate; a new approach for biomonitoring

High-molecular weight serum cytotoxic factor in rats treated with triphenyl phosphite: an approach for biological monitoring

A New Approach for Evaluation of Human Exposure to Environmental Hazardous Agents

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