In vitro degradation of carbamazepine and diclofenac by crude lignin peroxidase

Zhang, Yongjun; Geißen, Sven‐Uwe

doi:10.1016/j.jhazmat.2009.10.133

Cited by 121 publications

(59 citation statements)

References 22 publications

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“…Most of the studies used very low concentrations, and also, most studies used white-rot fungi. For example, the white-rot fungus Phanerochaete chrysosporium was able to metabolize 5 µg mL-1 DIC by its lignin peroxidase (Zhang and Geißen, 2010). Another white-rot fungus, Trametes versicolor successfully transformed higher concentrations (10 µg mL-1) of DIC into 4'-OH-DIC and 5-OH-DIC .…”

Section: Discussionmentioning

confidence: 99%

Efficient biotransformation of non-steroid anti-inflammatory drugs by endophytic and epiphytic fungi from dried leaves of a medicinal plant, Plantago lanceolata L.

Gonda

Kiss‐Szikszai

Szűcs

et al. 2016

International Biodeterioration & Biodegradation

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In the current study, decomposition of diclofenac, diflunisal, ibuprofen, mefenamic acid and piroxicam was tested using nine identified strains of endophytic and epiphytic fungi (from Ascomycota) adapted to natural products resembling the pharmaceuticals. The strains were isolated from a medicinal plant, Plantago lanceolata leaves. Metabolites were tentatively identified by liquid chromatography -tandem mass spectrometry ).Eighteen of the 45 combinations resulted in significant decrease of the concentration of the NSAIDs in model solutions. The most active strains were Aspergillus nidulans and Bipolaris tetramera, while Epicoccum nigrum and Aspergillus niger showed somewhat less potency. Piroxicam and diclofenac were most resistant to biotransformation, while ibuprofen and mefenamic acid were efficiently metabolized by most strains. Ten metabolites could be tentatively identified, includinghydroxy-metabolites of all tested NSAIDs, and a dihydroxy-metabolite of piroxicam. This biotransformation is likely to modify the toxicity and bioaccumulation potential of these pharmaceuticals.The results highlight the applicability of polyphenol-rich dried medicinal plant materials as an excellent source of fungi with high biotransforming potential. The results also suggest more in-depth testing of these fungi for biodegradation processes.

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Section: Discussionmentioning

confidence: 99%

Efficient biotransformation of non-steroid anti-inflammatory drugs by endophytic and epiphytic fungi from dried leaves of a medicinal plant, Plantago lanceolata L.

Gonda

Kiss‐Szikszai

Szűcs

et al. 2016

International Biodeterioration & Biodegradation

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“…In view of the results presented here, enzymatic degradation could be studied as a potential alternative for WWTP, since a total removal of DCF in short times (25 min) and at very low enzyme concentration was observed. Another ligninolytic enzyme, LiP, was used to remove DCF, obtaining complete degradation of 5 mg l -1 in 2 h using considerably higher amounts of H 2 O 2 (3 mg l -1 ) (Zhang and Geißen 2010). However, the concentration of enzyme, which is likely to determine the feasibility of the process, was not optimized.…”

Section: Antibiotics: Sulfamethoxazolementioning

confidence: 99%

“…A single treatment with laccase-HBT was partially effective removing CBZ, but a repeated treatment eliminated 60% after 48 h (Hata et al 2010b). Besides, Zhang and Geißen (2010) found that CBZ was hardly degraded by LiP (mostly below 10%). For future research, lipid peroxidation may be considered (Bogan et al 1996).…”

Section: Antiepilectics (Carbamazepine)mentioning

confidence: 99%

“…have been evaluated for the treatment of wastewaters (Duran and Esposito 2000). It has recently been demonstrated that manganese peroxidase (MnP), horseradish peroxidase and laccase are effective in removing the estrogenic activities of endocrine disrupting chemicals such as bisphenol A, nonylphenol, estrone, 17b-estradiol and ethinylestradiol (Tsutsumi et al 2001;Suzuki et al 2003;Tamagawa et al 2006;Cabana et al 2007;Auriol et al 2008), that lignin peroxidase (LiP) can attack the anti-inflammatory diclofenac (Zhang and Geißen 2010), and that the laccase-mediator system can remove carbamazepine (Hata et al 2010b).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Oxidation of pharmaceutically active compounds by a ligninolytic fungal peroxidase

et al. 2010

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Pharmaceuticals are an important group of emerging pollutants with increasing interest due to their rising consumption and the evidence for ecotoxicological effects associated to trace amounts in aquatic environments. In this paper, we assessed the potential degradation of a series of pharmaceuticals: antibiotics (sulfamethoxazole), antidepressives (citalopram hydrobromide and fluoxetine hydrochloride), antiepileptics (carbamazepine), anti-inflammatory drugs (diclofenac and naproxen) and estrogen hormones (estrone, 17β-estradiol, 17α-ethinylestradiol) by means of a versatile peroxidase (VP) from the ligninolytic fungus Bjerkandera adusta. The effects of the reaction conditions: VP activity, organic acid concentration and H(2)O(2) addition rate, on the kinetics of the VP based oxidation system were evaluated. Diclofenac and estrogens were completely degraded after only 5-25 min even with a very low VP activity (10 U l(-1)). High degradation percentages (80%) were achieved for sulfamethoxazole and naproxen. Low or undetectable removal yields were observed for citalopram (up to 18%), fluoxetine (lower than 10%) and carbamazepine (not degraded).

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“…In addition, these enzymes also catalyse the degradation of a wide variety of organic pollutants, such as dye, carbamazepine, diclofenac and so on [9][10][11]. As we know, ligninolytic enzymes (LiP and MnP) secreted by Phanerochaete chrysosporium (P. chrysosporium) could catalyze the degradation of lignin to accelerate the compost process [12].…”

Section: Introductionmentioning

confidence: 99%

Effects of ratio of manganese peroxidase to lignin peroxidase on transfer of ligninolytic enzymes in different composting substrates

Zhao

Zeng

et al. 2012

Biochemical Engineering Journal

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In vitro degradation of carbamazepine and diclofenac by crude lignin peroxidase

Cited by 121 publications

References 22 publications

Efficient biotransformation of non-steroid anti-inflammatory drugs by endophytic and epiphytic fungi from dried leaves of a medicinal plant, Plantago lanceolata L.

Efficient biotransformation of non-steroid anti-inflammatory drugs by endophytic and epiphytic fungi from dried leaves of a medicinal plant, Plantago lanceolata L.

Oxidation of pharmaceutically active compounds by a ligninolytic fungal peroxidase

Effects of ratio of manganese peroxidase to lignin peroxidase on transfer of ligninolytic enzymes in different composting substrates

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