In Vitro Degradation of PLCL/nHA Biodegradable Scaffolds

Dı́az, Esperanza; Puerto, Igor

doi:10.1080/03602559.2014.961087

Cited by 15 publications

(9 citation statements)

References 22 publications

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“…Degradation that is too fast could compromise the mechanical integrity of the scaffold, while if it is too slow, the scaffold would interfere in the correct integration of the regenerated tissue. The scaffold should ideally have a speed of degradation equal to or slightly slower than the growth of the tissue [ 6 , 9 , 18 ].…”

Section: Resultsmentioning

confidence: 99%

The Influence of Copolymer Composition on PLGA/nHA Scaffolds’ Cytotoxicity and In Vitro Degradation

et al. 2017

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The influence of copolymer composition on Poly(Lactide-co-Glycolide)/nanohydroxyapatite (PLGA/nHA) composite scaffolds is studied in the context of bone tissue engineering and regenerative medicine. The composite scaffolds are fabricated by thermally-induced phase separation and the effect of bioactive nanoparticles on their in vitro degradation in phosphate-buffered solution at 37 °C is analyzed over eight weeks. The indirect cytotoxicity evaluation of the samples followed an adaptation of the ISO 10993-5 standard test method. Based on the measurement of their molecular weight, molar mass, pH, water absorption and dimensions, the porous scaffolds of PLGA with a lower lactide/glycolide (LA/GA) molar ratio degraded faster due to their higher hydrophilicity. All of the samples without and with HA are not cytotoxic, demonstrating their potential for tissue engineering applications.

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Section: Resultsmentioning

confidence: 99%

The Influence of Copolymer Composition on PLGA/nHA Scaffolds’ Cytotoxicity and In Vitro Degradation

et al. 2017

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“…Their research revealed that both NF-PLLA and nHA/NF-PLLA had a faster significantly degradation rate, due to their much larger SSA, compared to poly( L -lactide). Similarly, Diaz and Puerto (2015) examined the effect of bioactive nanoparticles on the in vitro degradation of nHA/poly(L-lactide-co-ε-caprolactone) (nHA/PLCL) composite scaffolds and found that the rate of degradation was significantly dependent on the concentration of nHA [ 59 ]. At 10%, 30% and 50% of total polymer mass the authors incorporated nHA into PLCL and observed that the rate of degradation of the scaffolds was significantly slower with the increase of nHA content compared to lower nHA concentrations and that of pure PLCL (Fig.…”

Section: Nha/synthetic Polymers Degradationmentioning

confidence: 99%

“…Investigation into the effect of nHA nanoparticles on the degradation of PLCL: A) Profile of Mw versus degradation time for PLC/nHA composite scaffolds; B) Changes of water absorption versus degradation time for PLCL/nHA composite scaffold; C) Scanning electron microscopy imaging of PLCL surface morphology: (a) PLCL after two weeks of in vitro degradation, (b) PLCL/10 wt% nHA after four weeks of in vitro degradation (c) PLCL after six weeks of in vitro degradation, and (d)) PLCL/50 wt% nHA after four weeks of in vitro degradation [ 59 ].…”

Section: Fig (1)mentioning

confidence: 99%

Nanohydroxyapatite Effect on the Degradation, Osteoconduction and Mechanical Properties of Polymeric Bone Tissue Engineered Scaffolds

Salmasi¹,

Nayyer²,

Seifalian³

et al. 2016

TOORTHJ

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BACKGROUNDStatistical reports show that every year around the world approximately 15 million bone fractures occur; of which up to 10% fail to heal completely and hence lead to complications of non-union healing. In the past, autografts or allografts were used as the “gold standard” of treating such defects. However, due to various limitations and risks associated with these sources of bone grafts, other avenues have been extensively investigated through which bone tissue engineering; in particular engineering of synthetic bone graft substitutes, has been recognised as a promising alternative to the traditional methods.METHODSA selective literature search was performed.RESULTSBone tissue engineering offers unlimited supply, eliminated risk of disease transmission and relatively low cost. It could also lead to patient specific design and manufacture of implants, prosthesis and bone related devices. A potentially promising building block for a suitable scaffold is synthetic nanohydroxyapatite incorporated into synthetic polymers. Incorporation of nanohydroxyapatite into synthetic polymers has shown promising bioactivity, osteoconductivity, mechanical properties and degradation profile compared to other techniques previously considered.CONCLUSIONScientific research, through extensive physiochemical characterisation, in vitro and in vivo assessment has brought together the optimum characteristics of nanohydroxyapatite and various types of synthetic polymers in order to develop nanocomposites of suitable nature for bone tissue engineering. The aim of the present article is to review and update various aspects involved in incorporation of synthetic nanohydroxyapatite into synthetic polymers, in terms of their potentials to promote bone growth and regeneration in vitro, in vivo and consequently in clinical applications.

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“…Hydroxyapatite (HAP, Ca 10 (PO 4 ) 6 (OH) 2 ), the main inorganic component of bone, has caused considerable interest for bone substitution and regeneration, owing to its strong osteoconductive properties, bone-bonding ability, preeminent biocompatibility and bioactivity [ 11 , 12 , 13 ]. Recently, Lee et al prepared nanofibrous PLGA/Gelatin/HAP scaffolds via an electrospinning method and found that the scaffolds exhibited improved biocompatibility and osteoconductivity compared with the PLGA/Gelatin scaffolds [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Characterization and Bioactivity Evaluation of (Polyetheretherketone/Polyglycolicacid)-Hydroyapatite Scaffolds for Tissue Regeneration

Shuai

et al. 2016

Materials

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Bioactivity and biocompatibility are crucial for tissue engineering scaffolds. In this study, hydroxyapatite (HAP) was incorporated into polyetheretherketone/polyglycolicacid (PEEK/PGA) hybrid to improve its biological properties, and the composite scaffolds were developed via selective laser sintering (SLS). The effects of HAP on physical and chemical properties of the composite scaffolds were investigated. The results demonstrated that HAP particles were distributed evenly in PEEK/PGA matrix when its content was no more than 10 wt %. Furthermore, the apatite-forming ability became better with increasing HAP content after immersing in simulated body fluid (SBF). Meanwhile, the composite scaffolds presented a greater degree of cell attachment and proliferation than PEEK/PGA scaffolds. These results highlighted the potential of (PEEK/PGA)-HAP scaffolds for tissue regeneration.

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In Vitro Degradation of PLCL/nHA Biodegradable Scaffolds

Cited by 15 publications

References 22 publications

The Influence of Copolymer Composition on PLGA/nHA Scaffolds’ Cytotoxicity and In Vitro Degradation

The Influence of Copolymer Composition on PLGA/nHA Scaffolds’ Cytotoxicity and In Vitro Degradation

Nanohydroxyapatite Effect on the Degradation, Osteoconduction and Mechanical Properties of Polymeric Bone Tissue Engineered Scaffolds

Characterization and Bioactivity Evaluation of (Polyetheretherketone/Polyglycolicacid)-Hydroyapatite Scaffolds for Tissue Regeneration

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