In Vitro Degradation of Polydimethylsiloxanes in Breast Implant Applications

Ramião, Nilza; Martins, Pedro S.; Barroso, Maria da Luz; Dm, Santos; Fernandes, A. A.

doi:10.5301/jabfm.5000354

Cited by 9 publications

(8 citation statements)

References 26 publications

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“…Silk hydrogels ( Figure 4b) are easily adjustable in terms of mechanical properties and water content, so that the modification of these properties can significantly impact cell growth and function [83]. Control of the biodegradation rate of the silk hydrogel and its high bioactivity makes this biomaterial a choice for soft tissue engineering in comparison to other hydrogel-based formulations, such as polydimethylsiloxane (PDMS) and agarose [84,85], that show a negligible degradation due to the lack, in mammalian tissues, of enzymes able to decompose such materials [86,87]. A tunable degradation rate can ensure enough time for the regeneration of damaged nervous tissue.…”

Section: Silk Hydrogelsmentioning

confidence: 99%

Silk Fibroin: An Ancient Material for Repairing the Injured Nervous System

et al. 2021

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Silk refers to a family of natural fibers spun by several species of invertebrates such as spiders and silkworms. In particular, silkworm silk, the silk spun by Bombyx mori larvae, has been primarily used in the textile industry and in clinical settings as a main component of sutures for tissue repairing and wound ligation. The biocompatibility, remarkable mechanical performance, controllable degradation, and the possibility of producing silk-based materials in several formats, have laid the basic principles that have triggered and extended the use of this material in regenerative medicine. The field of neural soft tissue engineering is not an exception, as it has taken advantage of the properties of silk to promote neuronal growth and nerve guidance. In addition, silk has notable intrinsic properties and the by-products derived from its degradation show anti-inflammatory and antioxidant properties. Finally, this material can be employed for the controlled release of factors and drugs, as well as for the encapsulation and implantation of exogenous stem and progenitor cells with therapeutic capacity. In this article, we review the state of the art on manufacturing methodologies and properties of fiber-based and non-fiber-based formats, as well as the application of silk-based biomaterials to neuroprotect and regenerate the damaged nervous system. We review previous studies that strategically have used silk to enhance therapeutics dealing with highly prevalent central and peripheral disorders such as stroke, Alzheimer’s disease, Parkinson’s disease, and peripheral trauma. Finally, we discuss previous research focused on the modification of this biomaterial, through biofunctionalization techniques and/or the creation of novel composite formulations, that aim to transform silk, beyond its natural performance, into more efficient silk-based-polymers towards the clinical arena of neuroprotection and regeneration in nervous system diseases.

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Section: Silk Hydrogelsmentioning

confidence: 99%

Silk Fibroin: An Ancient Material for Repairing the Injured Nervous System

et al. 2021

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“…Biomaterial degradation was studied on virgin implant shells. Stiffening was observed induced by degradation ( Martins et al, 2017 ). These phenomena, allied to tissue-tissue and tissue-implant friction and to external loads, may alter the implants’ performance and durability.…”

Section: Introductionmentioning

confidence: 99%

A review of bioengineering techniques applied to breast tissue: Mechanical properties, tissue engineering and finite element analysis

Teixeira

Martins

2023

Front. Bioeng. Biotechnol.

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Female breast cancer was the most prevalent cancer worldwide in 2020, according to the Global Cancer Observatory. As a prophylactic measure or as a treatment, mastectomy and lumpectomy are often performed at women. Following these surgeries, women normally do a breast reconstruction to minimize the impact on their physical appearance and, hence, on their mental health, associated with self-image issues. Nowadays, breast reconstruction is based on autologous tissues or implants, which both have disadvantages, such as volume loss over time or capsular contracture, respectively. Tissue engineering and regenerative medicine can bring better solutions and overcome these current limitations. Even though more knowledge needs to be acquired, the combination of biomaterial scaffolds and autologous cells appears to be a promising approach for breast reconstruction. With the growth and improvement of additive manufacturing, three dimensional (3D) printing has been demonstrating a lot of potential to produce complex scaffolds with high resolution. Natural and synthetic materials have been studied in this context and seeded mainly with adipose derived stem cells (ADSCs) since they have a high capability of differentiation. The scaffold must mimic the environment of the extracellular matrix (ECM) of the native tissue, being a structural support for cells to adhere, proliferate and migrate. Hydrogels (e.g., gelatin, alginate, collagen, and fibrin) have been a biomaterial widely studied for this purpose since their matrix resembles the natural ECM of the native tissues. A powerful tool that can be used in parallel with experimental techniques is finite element (FE) modeling, which can aid the measurement of mechanical properties of either breast tissues or scaffolds. FE models may help in the simulation of the whole breast or scaffold under different conditions, predicting what might happen in real life. Therefore, this review gives an overall summary concerning the human breast, specifically its mechanical properties using experimental and FE analysis, and the tissue engineering approaches to regenerate this particular tissue, along with FE models.

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“…To reach our purpose, we mixed Dowsil TM SE 1700 and Sylgard 184 silicon elastomers to obtain a PDMS blend. PDMS is widely used in silicone medical devices and implants due to its non-toxic, gas permeable, and biostable properties [15][16][17][18]; PDMS also degrades very slowly in vivo [19,20]. Importantly, recent studies have shown that 3D printing of nanoparticle-free PDMS into different organ models showed enhanced cell adhesion behavior compared to non-3D-printed models [21] and that micropatterned PDMS functionalized with PLL and hyaluronic acid can minimize capsular contracture [15].…”

Section: Resultsmentioning

confidence: 99%

Injectable polymer/nanomaterial composites for the fabrication of three-dimensional biomaterial scaffolds

2020

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Current tissue engineering techniques have been intensively focused on creating injectable systems that can be used in minimally invasive surgery and controlled local drug delivery applications. The materials developed so far are based on natural and synthetic polymers and their nanocomposites, but many of them fail to simultaneously provide mechanical stability, stretchability and enhanced cell adhesiveness. In this context, to generate advanced injectable nanocomposite polymers that concurrently possess several properties, we used nanomaterials as well as nanomaterials that are chemically functionalized with bioactive molecules. Our 3D-printed polymer/nanomaterial composites (nanocomposite polymers) displayed enhanced mechanical properties, good shape fidelity, non-toxicity, stretchability, biostability and cell adhesiveness.

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In Vitro Degradation of Polydimethylsiloxanes in Breast Implant Applications

Cited by 9 publications

References 26 publications

Silk Fibroin: An Ancient Material for Repairing the Injured Nervous System

Silk Fibroin: An Ancient Material for Repairing the Injured Nervous System

A review of bioengineering techniques applied to breast tissue: Mechanical properties, tissue engineering and finite element analysis

Injectable polymer/nanomaterial composites for the fabrication of three-dimensional biomaterial scaffolds

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