In vitro detection of calcium in bone by modified carbon dots

Krishna, Amresh; Radhakumary, C.; Sreenivasan, K.

doi:10.1039/c3an01239e

Cited by 27 publications

(22 citation statements)

References 26 publications

(25 reference statements)

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“…Similar observation has been reported earlier 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 9 also 25,35,36 . Similar observation has been reported earlier 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 9 also 25,35,36 .…”

Section: Page 7 Of 20supporting

confidence: 89%

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Detection and imaging of fatty plaques in blood vessels using functionalized carbon dots

2015

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Risk of developing atherosclerosis is proportional to blood cholesterol level which in turn eventually leads to heart attack. Since a large number of asymptomatic young people have evidence of atherosclerosis it is highly necessary to diagnose it at the earliest. This communication depicts a simple method to visualize cholesterol deposits using digitonin (DG) conjugated carbon dots (CDs). Physico chemical characterizations and preliminary blood compatibility evaluation of the functionalized CDs (CDDG) were successfully carried out. It is found that the probes could selectively bind cholesterol as evident from their ability to image cholesterol doped polymer films and tissues with heavy fatty plaques suspended in blood serum.An early visualization of cholesterol rich plaques using fluorescent nano probes reported here may aid in diagnosis of atherosclerosis and it seems that our finding may catalyze further developments in this imperative domain. The data emerged from the study also indicate that the novel probe can be used for the selective detection of cholesterol in solution.

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Section: Page 7 Of 20supporting

confidence: 89%

“…However, their toxicity and water insolubility limit their application in biomedical fields. CD based probes for locating calcium rich sites in bone cracks has been reported from our group 25 . Aptamer functionalized CDs for sensitive and selective detection of thrombin has been reported by Xu et al 24 .…”

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confidence: 97%

Detection and imaging of fatty plaques in blood vessels using functionalized carbon dots

2015

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“…38, 39 Besides these two C-dots, a third type of C-dots from glycerin (CD3) was also prepared to explore the bone-binding properties. These glycerin-based C-dots have been shown recently that they can accumulate at fresh bone cuts ex vivo , 24, 25 thus it is of interest to explore their bone binding properties in vivo .…”

Section: Resultsmentioning

confidence: 99%

“…Only recently, interactions of C-dots with ex vivo samples, extracted and cracked bones, have been reported using C-dots functionalized with glutamic acid. 24, 25 …”

Section: Introductionmentioning

confidence: 99%

Carbon dots: promising biomaterials for bone-specific imaging and drug delivery

et al. 2017

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Bone-related diseases and dysfunctions are heavy burdens on our increasingly aged society. One important strategy to relieve this problem is through early detection and treatment of bone-related diseases. Towards this goal, there has been constant interest in developing novel bone-specific materials for imaging and drug delivery. Currently, however, materials that have high affinity and specificity towards bone are very limited. Carbon dots (C-dots) synthesized from carbon nanopowder bind to calcified bones in vivo with high affinity and specificity. In this study we show that bone binding is highly unique to a specific type of C-dots, and that this binding is non-toxic. Significantly, C-dots derived from other raw materials did not show any bone binding properties. These differences are attributed to differences in surface chemistry of C-dots preparations, highlighting the heterogeneous nature of C-dots. Importantly, bone-binding by carbon nanopowder derived C-dots are not significantly altered by chemical functionalization of their surface. These unique properties indicate the potential applications of carbon nanopowder-derived C-dots as highly bone-specific bioimaging agents and drug carriers.

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“…20 GA and aspartic acid peptides have been used for both bone-targeting and drug delivery purposes. 25 Here, amino-functionalized CDs prepared as reported earlier 26 were conjugated with GA and ciprooxacin simultaneously via EDC chemistry to locate bone cracks and deliver appropriate drugs to facilitate rapid healing and check infection. It is the most commonly used antibiotic to treat infections of the urinary tract, abdomen, bone and skin.…”

Section: Introductionmentioning

confidence: 99%

Functionalized carbon dots enable simultaneous bone crack detection and drug deposition

et al. 2014

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Recently, carbon dots (CDs) have become one of the most sought nanomaterials for biological applications owing to their excellent fluorescence, chemical inertness and biocompatibility. This article depicts the generation of a fluorescent nano probe using CDs for viewing bone cracks and simultaneous drug delivery to the cracked or infected sites. Water soluble polyethylene glycol diamine capped CDs were conjugated with glutamic acid (GA), a calcium targeting ligand, and ciprofloxacin as an antibacterial model drug. Physicochemical characterizations, cytotoxicity evaluation, haemolysis and antibacterial activity studies of the synthesized probe and its ability to target onto bone are demonstrated. Our results indicate that there is significant scope in developing functionalized CDs as theranostic agents.

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In vitro detection of calcium in bone by modified carbon dots

Cited by 27 publications

References 26 publications

Detection and imaging of fatty plaques in blood vessels using functionalized carbon dots

Detection and imaging of fatty plaques in blood vessels using functionalized carbon dots

Carbon dots: promising biomaterials for bone-specific imaging and drug delivery

Functionalized carbon dots enable simultaneous bone crack detection and drug deposition

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