In vitro dissolution methodology, mini-Gastrointestinal Simulator (mGIS), predicts better in vivo dissolution of a weak base drug, dasatinib

In-line derivative spectroscopy as a promising application to a small-scale in vitro transfer model in biorelevant supersaturation and precipitation testing

“…Manual sampling followed by HPLC analytics is typically used for gastrointestinal in vitro transfer model approaches . This common procedure of sample preparation can lead to major issues during drug concentration measurements in supersaturated states, such as:…”

“…Manual sampling followed by HPLC analytics is typically used for gastrointestinal in vitro transfer model approaches. [3,17,18,23] This common procedure of sample preparation can lead to major issues during drug concentration measurements in supersaturated states, such as: 1. Limited sampling frequency, with the result that the supersaturation profile may be captured inaccurately; 2.…”

Development of a discriminative biphasic in vitro dissolution test and correlation with in vivo pharmacokinetic studies for differently formulated racecadotril granules

“…Examples are artificial stomach-duodenum models [6,7], physical stress models [8,9], dissolution-permeation models [10,11] and digestion model [12,13]. In particular, biphasic dissolution tests could be suitable for BCS II drugs due to poor aqueous solubility.…”

Evolution of a mini-scale biphasic dissolution model: Impact of model parameters on partitioning of dissolved API and modelling of in vivo-relevant kinetics

“…Thus, it holds the promise of a system that can evaluate most pharmaceutical compositions under one standardised experimental setting [9]. Nevertheless, the complexity of the TIM-1 limits it practicality for fast routine screening and development [8]. Additionally, the suitability for micro-or mini-scale needs to be evaluated.…”