In vitro dissolution profiles of enteric coated microsphere pancreatin preparations at different pH values

Gan, K. H.; Geus, W.P.; Heijerman, H.G.M.; Bakker, Wouter; Lamers, C. B. H. W.

doi:10.1016/0016-5085(95)24082-9

Cited by 1 publication

(2 citation statements)

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“…Different acid‐resistant coatings are used to protect the enzymes and, depending on which coating is used, the enzymes are released (at differing rates) only as the pH increases to 5 and 6 or greater (16,20). Therefore, to understand the site of enzyme release in the intestine, we must accurately define the pH along the GI tract.…”

Section: General Comments On Enteric‐coated Pancreatic Enzyme Supplem...mentioning

confidence: 99%

“…If gastric pH increases to >5, some of the pancreatic enzymes administered probably are released in the stomach (16,20), with the amount released depending on the pH reached and the amount of time pH remains >5. The released amylase and lipase especially, which are not rapidly emptied from the stomach, are liable to denaturation by proteases and decreasing pH (16), which will decrease the therapeutic efficacy of the administered enzymes.…”

Section: General Comments On Enteric‐coated Pancreatic Enzyme Supplem...mentioning

confidence: 99%

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Gastrointestinal pH, Motility/Transit and Permeability in Cystic Fibrosis

Gregory

1996

J. pediatr. gastroenterol. nutr.

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SummaryI reviewed the literature (1966‐1994) concerning gastrointestinal (GI) pH, motility/transit, and permeability in cystic fibrosis (CF). Most studies reported were performed with very small numbers of patients, but even when considered together the published data do not confirm some generally expressed views on these topics. The only clear findings were a high incidence of gastroesophageal reflux in CF; pre‐ and postprandial duodenal pH is 1‐2 U lower in patients with CF than in healthy controls; and small intestinal paracellular permeability is 4‐10 times greater than normal in CF. Some patients showed abnormalities of lower esophageal sphincter pressure and of esophageal motility, but apart from one case study other disturbances of GI motility have not been reported. The results of hydrogen breath tests strongly suggest that oro‐cecal transit is slowed in CF, but these results must be confirmed by an alternative test. Measurements of colonic transit and colonic permeability have not been reported. The few studies of gastric emptying reported are controversial. Whether GI pH, apart from duodenal pH, is normal in CF or whether a subset of patients has exceptionally acid intestinal contents requiring specialized pancreatic enzyme supplementation to normalize digestion is not clear. Finally, I briefly discuss the findings in relation to their possible impact on the pathogenesis of fibrosing colonopathy.

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Section: General Comments On Enteric‐coated Pancreatic Enzyme Supplem...mentioning

confidence: 99%

Section: General Comments On Enteric‐coated Pancreatic Enzyme Supplem...mentioning

confidence: 99%