In Vitro Dissolution Testing with Flow-Through Method: A Technical Note

Design and In Vivo Anti-Inflammatory Effect of Ketoprofen Delayed Delivery Systems

“…F20 dissolution behavior was further investigated using the USP apparatus 4 (flow-through, open-loop configuration), which is reported to closely mimic in vivo hydrodynamics and thus to better predict in vivo performance of solid oral dosage forms. [31][32][33] As shown in Figure 6, the apparatus 4 confirmed that F20 had enteric release behavior (19% of the drug released in 2 h at pH 1) and in SIF showed a slower rate than that obtained using the USP paddle method.…”

Development of cyclodextrin hydrogels for vaginal delivery of dehydroepiandrosterone

“…In particular, the slower release rates obtained with the flow‐through apparatus indicated that the medium flowing through the sample at the selected flow rate (4 ml/min) provided a relative mild shear force compared with that generated by the paddle agitation speed (10 rpm). An analogous result was observed by a comparison of the two methods in drug release studies from tablets …”

Assessment of Physical and Chemical Stability of Different Magnesium Compounds in Tablets

“…At a fixed moment of time, a sample of 5 mL was taken, then filtered using a 0.45 μm pore size filter; the magnesium content was determined with the use of an inductively coupled plasma optical emission spectrometer (ICP-OES) Optima 5300 DV (Perkin Elmer, USA). The equation LOD=3 sb/m (where sb was the standard deviation of 10 successive determination of blank and m was the slope of calibration curve) was used to calculate the limit of detection as being LOD=0.01 mg/L [21]. At the magnesium emission line (285 nm) were not revealed interferences with potassium, phosphorus and sodium.…”