In vitro drug permeation from chitosan pellets

Ferrari, Priscileila Colerato; Souza, Fagner Magalhães; Giorgetti, Leandro; Oliveira, Giselle F.; Chaud, Marco V.; Ferraz, Humberto Gomes; Evangelista, Raul Cesar

doi:10.1016/j.carbpol.2011.11.027

Cited by 14 publications

(8 citation statements)

References 20 publications

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“…The increased viscosity value obtained by the addition of COL was thought to lessen NLC motion in the formulation. Ferrari et al have studied the effect of chitosan on intestinal permeation and they have reported that the presence of CS in pellets provided controlled drug release and consequently, slower intestinal permeation (Ferrari et al, 2012).…”

Section: Ex-vivo Permeation and Penetration Studiesmentioning

confidence: 99%

Preparation and in vitro–in vivo evaluation of ofloxacin loaded ophthalmic nano structured lipid carriers modified with chitosan oligosaccharide lactate for the treatment of bacterial keratitis

Okur

Gökçe

Bozbıyık

et al. 2014

European Journal of Pharmaceutical Sciences

150

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Section: Ex-vivo Permeation and Penetration Studiesmentioning

confidence: 99%

Preparation and in vitro–in vivo evaluation of ofloxacin loaded ophthalmic nano structured lipid carriers modified with chitosan oligosaccharide lactate for the treatment of bacterial keratitis

Okur

Gökçe

Bozbıyık

et al. 2014

European Journal of Pharmaceutical Sciences

150

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“…Of all the various biomedical applications, we observed that drug delivery applications of Ch NPs are that which are being highly researched and investigated. Ch NPs targeted cancer theranostics, dermatological applications, and targeted parenteral drug delivery systems need to be seriously looked into [ 229 , 230 , 231 , 232 , 233 , 234 , 235 , 236 ]. With the advent of new strategies in overcoming the limitations of chitosan, we expect to see more chitosan research work in near future, especially in nasal and pulmonary drug delivery.…”

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Green Synthesized Chitosan/Chitosan Nanoforms/Nanocomposites for Drug Delivery Applications

Sivanesan

Gopal²,

Muthu³

et al. 2021

Polymers

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Chitosan has become a highlighted polymer, gaining paramount importance and research attention. The fact that this valuable polymer can be extracted from food industry-generated shell waste gives it immense value. Chitosan, owing to its biological and physicochemical properties, has become an attractive option for biomedical applications. This review briefly runs through the various methods involved in the preparation of chitosan and chitosan nanoforms. For the first time, we consolidate the available scattered reports on the various attempts towards greens synthesis of chitosan, chitosan nanomaterials, and chitosan nanocomposites. The drug delivery applications of chitosan and its nanoforms have been reviewed. This review points to the lack of systematic research in the area of green synthesis of chitosan. Researchers have been concentrating more on recovering chitosan from marine shell waste through chemical and synthetic processes that generate toxic wastes, rather than working on eco-friendly green processes—this is projected in this review. This review draws the attention of researchers to turn to novel and innovative green processes. More so, there are scarce reports on the application of green synthesized chitosan nanoforms and nanocomposites towards drug delivery applications. This is another area that deserves research focus. These have been speculated and highlighted as future perspectives in this review.

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“…Besides PVP, chitosan in solid dispersions also influenced drug delivery, demonstrating that the sample with a 1:9 drug: polymer ratio presents a more prolonged trans-resveratrol release. Chitosan is a polymer widely employed for controlling drug delivery, and the primary mechanism is due to its polymer swelling ability [58].…”

Section: Discussionmentioning

confidence: 99%

Solid Dispersions Incorporated into PVP Films for the Controlled Release of Trans-Resveratrol: Development, Physicochemical and In Vitro Characterizations and In Vivo Cutaneous Anti-Inflammatory Evaluation

et al. 2022

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Trans-resveratrol can promote various dermatological effects. However, its high crystallinity decreases its solubility and bioavailability. Therefore, solid dispersions have been developed to promote its amorphization; even so, they present as powders, making cutaneous controlled drug delivery unfeasible and an alternative necessary for their incorporation into other systems. Thus, polyvinylpyrrolidone (PVP) films were chosen with the aim of developing a controlled delivery system to treat inflammation and bacterial infections associated with atopic dermatitis. Four formulations were developed: two with solid dispersions (and trans-resveratrol) and two as controls. The films presented with uniformity, as well as bioadhesive and good barrier properties. X-ray diffraction showed that trans-resveratrol did not recrystallize. Fourier-transform infrared spectroscopy (FT-IR) and thermal analysis evidenced good chemical compatibilities. The in vitro release assay showed release values from 82.27 ± 2.60 to 92.81 ± 2.50% (being a prolonged release). In the in vitro retention assay, trans-resveratrol was retained in the skin, over 24 h, from 42.88 to 53.28%. They also had low cytotoxicity over fibroblasts. The in vivo assay showed a reduction in inflammation up to 66%. The films also avoided Staphylococcus aureus’s growth, which worsens atopic dermatitis. According to the results, the developed system is suitable for drug delivery and capable of simultaneously treating inflammation and infections related to atopic dermatitis.

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In vitro drug permeation from chitosan pellets

Cited by 14 publications

References 20 publications

Preparation and in vitro–in vivo evaluation of ofloxacin loaded ophthalmic nano structured lipid carriers modified with chitosan oligosaccharide lactate for the treatment of bacterial keratitis

Preparation and in vitro–in vivo evaluation of ofloxacin loaded ophthalmic nano structured lipid carriers modified with chitosan oligosaccharide lactate for the treatment of bacterial keratitis

Green Synthesized Chitosan/Chitosan Nanoforms/Nanocomposites for Drug Delivery Applications

Solid Dispersions Incorporated into PVP Films for the Controlled Release of Trans-Resveratrol: Development, Physicochemical and In Vitro Characterizations and In Vivo Cutaneous Anti-Inflammatory Evaluation

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