In vitro drug release studies on guar gum-based colon targeted oral drug delivery systems of 5-fluorouracil

Krishnaiah, Y. S. R.; Satyanarayana, V.; Kumar, Bimlesh; Karthikeyan, Ramadoss

doi:10.1016/s0928-0987(02)00081-7

Cited by 164 publications

(86 citation statements)

References 25 publications

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“…[102] Celecoxib a nonsteroidal anti-inflammatory drugs showed chemo-preventive potential against colorectal cancer after its release. Matrix tablets containing either 20 or 30% of GG are most likely to target celecoxib for local action in the colon.…”

Section: Effect On Colorectal Cancer and Colonic Neoplasiamentioning

confidence: 99%

“…Matrix tablets containing either 20 or 30% of GG are most likely to target celecoxib for local action in the colon. [102] Similarly, GG microspheres containing methotrexate (MTX) are prepared and characterized for local action after release in the colon. [103] GG microspheres were prepared by the emulsification method using glutaraldehyde as a crosslinking agent.…”

Section: Effect On Colorectal Cancer and Colonic Neoplasiamentioning

confidence: 99%

“…Intravenous administration of 5-fluorouracil for colon cancer therapy produces severe systemic side-effects due to its cytotoxic effect on normal cells. [102] For therapeutic purposes, biocompatible GA-stabilized gold nanocrystals (GA-AuNPs) were prepared and used as X-ray contrast agent in tumor bearing mice and dog. Single intratumoral injections of GA-AuNP resulted in X-ray contrast change of −26 HU in the tumor region after 1 h post-injection period.…”

Section: Use Of Gum In Development Of Drug Deliverymentioning

confidence: 99%

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Upadhyay

2017

IJGP

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The present review explains nutritional, therapeutic, and pharmaceutical potential of plant gum that is commonly applied to water-soluble, non-starch polysaccharides of commerce. This article also emphasizes commercial and domestic uses of important products of gum such as chicle and jelutong mainly non-elastic gums or chewing gums. These are also used in food, pharmaceutical, paper textile, and other industries. The present review also explains various biological activities such as antidiarrheic, antitumor, anti-inflammatory, anti-arthritic, antiparasitic, gastrourinary, antitumor, antiparasitic, antioxidant, chemopreventive, and gastroprotective activity of plant gums. These reduce stomach inflammation, system cleansing or to settle the intestines. Other uses for mesquite gum include treatment for lice, sore throat, cough, laryngitis, fever reduction, painful gums, and hemorrhoids and it can be used as a purgative. Gum arabic is a water-soluble dietary fiber rich in Ca , and decreases plasma phosphate concentration as well as urinary excretion of phosphate and Na + . Gums are used as adhesives, crystallization inhibitors, emulsifying agents, emulsion stabilizers, encapsulating agents, film formers, foam stabilizers, suspending agents, suspension stabilizers, or syneresis inhibitors and impart other specific properties. The gum is also used to a limited extent in polishes, contact insecticides and pesticides, photographic emulsions, and pharmaceuticals. This article suggests wider use of plant gums in generation of drug delivery system for cancer and brain tumor therapy. There is no doubt that chemical constituents of plant gums can be largely used for making therapeutic drugs because of their broadspectrum biological effectiveness.

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Section: Effect On Colorectal Cancer and Colonic Neoplasiamentioning

confidence: 99%

Section: Effect On Colorectal Cancer and Colonic Neoplasiamentioning

confidence: 99%

Section: Use Of Gum In Development Of Drug Deliverymentioning

confidence: 99%

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Upadhyay

2017

IJGP

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“…Fast-disintegrating 5-fluorouracil core tablets were compression coated with 60% (FHV-60), 70% (FHV-70) and 80% (FHV-80) of guar gum [126]. Oral colon-targeting drug delivery systems for celecoxib using guar gum as a carrier were developed.…”

Section: Polysaccharides As a Strategy For Targeting Colon Drug Deliverymentioning

confidence: 99%

Targeting Colon Drug Delivery by Natural Products

Kim¹

2012

Inflammatory Bowel Disease

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“…There have been a number of reports in the literature where the administration of 5-FU has been claimed to cause cytotoxic effects, including mucositis, [24][25][26] diarrhea, 27,28 alteration in normal microflora structure, 29 and translocation of bacteria. [30][31][32] Literature demonstrates that a number of researchers [33][34][35][36][37][38] have formulated colon-targeted drug delivery of 5-FU using various polysaccharides to overcome the side effects caused by 5-FU. An aspect that has been largely ignored is the cytotoxic effects that 5-FU may exert on the colonic bacteria that are involved in the metabolism of these polysaccharides (chitosan, xanthan gum [XG], amylose, and guar gum [GG], etc) and the release of the drugs in the subsequent doses.…”

Section: Introductionmentioning

confidence: 99%

A nanomedicine-promising approach to provide an appropriate colon-targeted drug delivery system for 5-fluorouracil

Singh¹,

Kotla²,

Tomar³

et al. 2015

IJN

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Targeted drug delivery plays a significant role in disease treatment associated with the colon, affording therapeutic responses for a prolonged period of time with low side effects. Colorectal cancer is the third most common cancer in both men and women with an estimated 102,480 cases of colon cancer and 40,340 cases of rectal cancer in 2013 as reported by the American Cancer Society. In the present investigation, we developed an improved oral delivery system for existing anticancer drugs meant for colon cancer via prebiotic and probiotic approaches. The system comprises three components, namely, nanoparticles of drug coated with natural materials such as guar gum, xanthan gum (that serve as prebiotics), and probiotics. The natural gums play a dual role of protecting the drug in the gastric as well as intestinal conditions to allow its release only in the colon. In vitro results obtained from these experiments indicated the successful targeted delivery of 5-fluorouracil to the colon. Electron microscopy results demonstrated that the prepared nanoparticles were spherical in shape and 200 nm in size. The in vitro release data indicated that the maximum release occurs at pH 7.2 and 7.4 with 93% of the drug released in the presence of 4% (w/v) of rat cecal content. In vivo results conclude a practical mechanism to maintain the integrity and intactness of the intestinal/colonic microflora, in the face of a “chemical attack” by oral colon-targeted drug delivery for colon cancer treatment.

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In vitro drug release studies on guar gum-based colon targeted oral drug delivery systems of 5-fluorouracil

Cited by 164 publications

References 25 publications

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Targeting Colon Drug Delivery by Natural Products

A nanomedicine-promising approach to provide an appropriate colon-targeted drug delivery system for 5-fluorouracil

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