In vitro drug release study from hydroxyapatite-alumina composites

Teixeira, José Maria; Alburquerque, J. S. V.; Duarte, Eden Batista; Silva, S. A.; Nogueira, Ricardo Emílio Ferreira Quevedo

doi:10.1007/s10971-018-4888-3

Cited by 8 publications

(1 citation statement)

References 34 publications

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“…These novel systems contain numerous advantages such as enhanced bioavailability, controlled and prolonged release, greater efficacy, and safety. − Moreover, the development of controlled release nanohybrids by encapsulating biomolecules into hydroxyapatite nanoparticles (HA-Nps) have recently gained popularity. HA-Nps are considered as promising candidates in medicinal applications due to their bioactivity and biocompatibility. − As a rich source of phosphorus, HA-Nps are also used in the field of agriculture. − Furthermore, hydroxyapatite surface offers rich opportunities for the immobilization of strategic chemicals through systematic surface modification. ,− However, the impact of surface morphology of HA-Nps on the encapsulation/release mechanism of these biomolecules remains to be explored. This requires a systematic study that monitors adsorption and desorption behavior in situ and in real time.…”

Section: Introductionmentioning

confidence: 99%

Mechanistic Insights into Interactions at Urea–Hydroxyapatite Nanoparticle Interface

et al. 2021

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Development of controlled release biomolecules by surface modification of hydroxyapatite nanoparticles has recently gained popularity in the areas of bionanotechnology and nanomedicine. However, optimization of these biomolecules for applications such as drug delivery, nutrient delivery requires a systematic understanding of binding mechanisms and interfacial kinetics at the molecular level between the nanomatrix and the active compound. In this research, urea is used as a model molecule to investigate its interactions with two morphologically different thin films of hydroxyapatite nanoparticles. These thin films were fabricated on quartz crystal piezoelectric sensors to selectively expose Ca 2+ and PO 4 3− sites of hydroxyapatite. Respective urea adsorption and desorption on both of these sites were monitored in situ and in real time in the phosphate buffer solution that mimics body fluids. The measured kinetic parameters, which corroborate structural predisposition for controlled release, show desorption rates that are one-tenth of the adsorption rates on both surfaces. Furthermore, the rate of desorption from the PO 4 3− site is one-half the rate of desorption from the Ca 2+ site. The Hill kinetic model was found to satisfactorily fit data, which explains cooperative binding between the hydroxyapatite nanoparticle thin film and urea. Fourier transform infrared spectra and X-ray photoemission spectra of the urea adsorbed on the above surfaces confirm the cooperative binding. It also elucidates the different binding mechanisms between urea and hydroxyapatite that contribute to the changes in the interfacial kinetics. These findings provide valuable information for structurally optimizing hydroxyapatite nanoparticle surfaces to control interfacial kinetics for applications in bionanotechnology and nanomedicine.

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