In-vitro dynamic micro-probing and the mechanical properties of human prostate tissues

Yang, Tao; Leung, Steve; Phipps, Simon; Reuben, Robert Lewis; McNeill, S. Alan; Habib, Fouad K.; Schnieder, A.; Stevens, Robert S.

doi:10.3233/thc-2006-144-511

Cited by 15 publications

(14 citation statements)

References 9 publications

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“…Early studies focused mainly on the use of one 'elasticity' parameter [42,56], but later studies added a layer of complexity to the mechanical properties of the prostate using a viscosity parameter as well [18,27,67]. Yang et al [67] were able to show that the two tissue types in prostate (stromal and epithelial) tissue have different mechanical properties. Sensitivity range (71-82%), specificity range (60-95%) [18,27,42,47,68,69] summarises the mechanical studies performed on prostate tissue.…”

Section: Direct Mechanical Assessment Methodsmentioning

confidence: 99%

Elasticity as a biomarker for prostate cancer: a systematic review

et al. 2013

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To systematically review the range of methods available for assessing elasticity in the prostate and to examine its use as a biomarker for prostate cancer. A systematic review of the electronic database PubMed was performed up to December 2012. All relevant studies assessing the use of elasticity as a biomarker for prostate cancer were included except those not studying human prostates or reporting a sensitivity, specificity or quantitative elasticity value. There has been much interest in the use of elasticity in the detection of prostate cancer and there have been many publications using various methods of detection. The most common method of assessment is an imaging method, called sonoelastography. Further imaging methods include ultrasound (US), three‐dimensional US and magnetic resonance elastography. These methods are reviewed for sensitivity and specificity. The other method of assessment is the mechanical method. These use quantitative elasticity values to differentiate benign from malignant areas of the prostate. This method of assessment has shown that the elasticity changes for differing Gleason grades and T stages of disease within the prostate. Quantitative elasticity values offer the potential of using ‘threshold’ elasticity values under which the prostate is benign. Tissue elasticity has great potential as a diagnostic and prognostic biomarker for prostate cancer and can be assessed using various methods. Currently transrectal sonoelastography has the most evidence supporting its use in clinical practice.

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Section: Direct Mechanical Assessment Methodsmentioning

confidence: 99%

Elasticity as a biomarker for prostate cancer: a systematic review

et al. 2013

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“…For sinusoidal excitation, | E *| is defined as the amplitude of the displacement phasor divided by the excitation force phasor and tan δ is their phase difference. Yang et al (35) report | E *| values of in vitro prostate tissue using dynamic microprobing performed at 3% and 5% precompression of epithelial tissue (360–510 kPa) and stromal tissue (190–245 kPa) for frequencies between 5 and 30 Hz. Phipps et al (36) collected fresh tissue specimens from patients undergoing transurethral resection of the prostate for benign or malignant prostatic enlargement.…”

Section: Elasticity Of Prostate: Literature Reviewmentioning

confidence: 99%

Transperineal prostate MR elastography: Initial in vivo results

Sahebjavaher

Baghani

Honarvar

et al. 2012

Magnetic Resonance in Med

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This article presents a new approach to magnetic resonance elastography of the prostate using transperineal mechanical excitation. This approach is validated using a prostate elasticity phantom and in vivo studies of healthy volunteers. It is demonstrated that the transperineal approach can generate shear wave amplitudes on the order of 6–30 μm in the mid‐gland region. The driver was implemented using an electromagnetic actuator with a hydraulic transmission system. The magnetic resonance elastography acquisition time has been reduced significantly by using a “second harmonic” approach. Displacement fields are processed using the established three‐dimensional local frequency estimation algorithm. The three‐dimensional curl‐based direct inversion was used to calculate the local wavelength. The traveling wave expansion algorithm was used to reconstruct the wave damping image for one case. Using the proposed method, it was possible to resolve lesions of 0.5 cc in the phantom study. Repeatability experiments were performed and analyzed. The results from this study indicate that transperineal magnetic resonance elastography—without an endorectal coil—is a suitable candidate for a patient study involving multiparametric magnetic resonance imaging of prostate cancer, where magnetic resonance elastography may provide additional information for improved diagnosis and image‐based surveillance. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.

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“…Ahn also showed that there was no significant difference in the mechanical properties of different areas of the posterior surface of the prostate, as long as the histopathology was the same . Carson et al, Phipps et al, and Yang et al reported similar findings, though they used different testing rigs as compared to the robot indenter of Ahns studies.…”

Section: Methods Of Mechanical Characterizationmentioning

confidence: 86%