In Vitro Effect ofZingiber officinaleExtract on Growth ofStreptococcus mutansandStreptococcus sanguinis

Abstract

Background and Objectives. Tooth decay is an infectious disease of microbial origin. Considering the increasing prevalence of antibiotic resistance due to their overuse and also their side effects, medicinal plants are now considered for use against bacterial infections. This study aimed to assess the effects of different concentrations of Zingiber officinale extract on proliferation of Streptococcus mutans and Streptococcus sanguinis in vitro. Materials and Methods. In this experimental study, serial dilutions of the extract were prepared in two sets of 10 test tubes for each bacterium (total of 20). Standard amounts of bacterial suspension were added; 100ƛ of each tube was cultured on prepared solid agar plates and incubated at 37°C for 24 hours. Serial dilutions of the extract were prepared in another 20 tubes and 100ƛ of each tube was added to blood agar culture medium while being prepared. The mixture was transferred to the plates. The bacteria were inoculated on plates and incubated as described. Results. The minimum inhibitory concentration (MIC) was 0.02 mg/mL for S. mutans and 0.3 mg/mL for S. sanguinis. The minimum bactericidal concentration (MBC) was 0.04 mg for S. mutans and 0.6 mg for S. sanguinis. Conclusion. Zingiber officinale extract has significant antibacterial activity against S. mutans and S. sanguinis cariogenic microorganisms.

Evaluation of Antifungal Activity of a 3-Extract Formulation in Topical Dosage Form and Its Safety Aspect

“…The marker compounds contained in ginger, particularly gingerol and shogaol, have been reported exhibit important antioxidant properties with remarkable anticancer, and antimutagenic effect [12], analgesic [13], inhibit melanoma [11], inhibit platelet aggregation [14], antihyperlipidemia [15], antidiabetes [16], ameliorate renal and pancreas damage [17], and so on. Certain compounds contained in (Z. officinale) demonstrate synergistic effect as auxiliary chemical agent against on C. albicans, Enterococcus faecalis, Escherichia coli, and their endotoxins [18] and also other microbes [19].…”

The Effect of Zingiber officinale Roscoe (Ginger) on Dentin Microhardness: An in vitro Study

“…officinale Roscoe oil was prepared using the hydro distillation method (Ali et al, 2002;Jantan et al, 2003). The concentration selected for this study was based on the respective minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) established in previous studies (Azizi et al, 2015;Lopez et al, 2005;Thosar et al, 2013) and has been reported to be effective against E. faecalis (Valera et al, 2015).…”

Untitled

“…47 Activity of extracts of Zingiber officinale (ginger) and Curcuma longa (curcumin) against Giardia lamblia in vitro and in vivo was studied. Faecal cyst and intestinal trophozoite counts reduction was seen and in vivo ginger was found more effective.…”