2023
DOI: 10.3390/antibiotics12091409
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In Vitro Effect of Three-Antibiotic Combinations plus Potential Antibiofilm Agents against Biofilm-Producing Mycobacterium avium and Mycobacterium intracellulare Clinical Isolates

Sara Batista,
Mariana Fernandez-Pittol,
Lorena San Nicolás
et al.

Abstract: Patients with chronic pulmonary diseases infected by Mycobacterium avium complex (MAC) often develop complications and suffer from treatment failure due to biofilm formation. There is a lack of correlation between in vitro susceptibility tests and the treatment of clinical isolates producing biofilm. We performed susceptibility tests of 10 different three-drug combinations, including two recommended in the guidelines, in biofilm forms of eight MAC clinical isolates. Biofilm developed in the eight isolates foll… Show more

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“…Once established, it is incredibly difficult to kill bacteria in this form. The MBCs of M. avium in biofilms are four to six times higher than in planktonic form treated with a single antibiotic ( Batista et al, 2023 ). As the majority of chronic and recurrent bacterial infections are caused by bacteria in biofilm, being able to penetrate, and break-down, the biofilm will be crucial to the success of new therapeutics ( Mah, 2012 ).…”
Section: Challenges To Developing New Therapiesmentioning
confidence: 99%
“…Once established, it is incredibly difficult to kill bacteria in this form. The MBCs of M. avium in biofilms are four to six times higher than in planktonic form treated with a single antibiotic ( Batista et al, 2023 ). As the majority of chronic and recurrent bacterial infections are caused by bacteria in biofilm, being able to penetrate, and break-down, the biofilm will be crucial to the success of new therapeutics ( Mah, 2012 ).…”
Section: Challenges To Developing New Therapiesmentioning
confidence: 99%