In vitro effect of vegetable and fruit juices on the mutagenicity of 2-amino-3-methylimidazo[4,5-f]quinoline, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline

Edenharder, R.; Kurz, Pat; John, Kaarthik; Burgard, S.; Seeger, K.

doi:10.1016/0278-6915(94)90042-6

Cited by 59 publications

(22 citation statements)

References 34 publications

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“…Java plum (Syzygium cumini) was tested by E. coli rifampicin resistance and showed strong antimutagenicity (Saxena et al, 2013). The antimutagenic potential of acetone and 2-propanol extract of plums was reported to be significant (Edenharder et al, 1994). The outcome of this study corroborates the previous reports in regards to the antimutagenic effect of plum extracts.…”

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confidence: 87%

Analyzing Biological Properties of Some Plum Genotypes Grown in Turkey

Murathan

Arslan

Erbil

2020

International Journal of Fruit Science

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In the current study, the biochemical components, antioxidant activity, antibacterial activity, and antimutagenic activity of 5 plum (Demal, White Cancur, Cancur, Red plum, and Sugar plum) fruits grown in Posof/Ardahan, Turkey were investigated. While other genotypes are cultured, Demal genotype grows wild. The highest total ascorbic acid (TAC; 454 mg/100 g FW (fresh weight)) and total flavonoid content (TFC; 29.1 mg/100 g FW) were detected in Red plum genotype. The Ferric Reducing Antioxidant Power (FRAP) and 2,2ʹ-azino-bis 3-ethylbenzothiazoline-6-sulfonic acid (ABTS) values were obtained highest in Sugar plum (563.8 µmol/g and 50.9%, respectively). 2,2-diphenyl-1-picrylhydrazyl (DPPH) content among the plum genotypes was also insignificant. Gallic acid, naringin, resveratrol, and caffeic acid were the predominant phenolic compounds in plum fruits. The resveratrol content in Red plum was significantly higher. The total sugar was found maximum in White Cancur and Cancur genotypes (545.15 and 546.08 mg/g, respectively). Twenty-three fatty acids were identified and quantified. Palmitic acid was the most abundant saturated fatty acid (SFA) in all samples. It was observed that all the plum extracts, except Cancur, exhibited antibacterial activity against the experimental bacteria. Further, different doses of plum extracts exhibited the antimutagenic effect.

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confidence: 87%

Analyzing Biological Properties of Some Plum Genotypes Grown in Turkey

Murathan

Arslan

Erbil

2020

International Journal of Fruit Science

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“…The antimutagenic activity was demonstrated by a study on colorectal carcinogenesis inducted by 1,2-dimethylhydrazine (DMH) [63] confirming previous reports in which juice or extracts of plants containing large amounts of anthocyanins acted as inhibitors of heterocyclic amine mutagenesis [64, 65]. C3G also prevented genomic DNA damage in human fibroblast [66], hepatoma-derived cell line (Hep G2) [67], colonic adenocarcinoma (CaCo-2) [68], melanoma [69], and vulva carcinoma A431 [70] cell lines.…”

Section: Components Of Red Orangesupporting

confidence: 59%

Red Orange: Experimental Models and Epidemiological Evidence of Its Benefits on Human Health

Grosso

Galvano

Mistretta

et al. 2013

Oxidative Medicine and Cellular Longevity

111

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In recent years, there has been increasing public interest in plant antioxidants, thanks to the potential anticarcinogenic and cardioprotective actions mediated by their biochemical properties. The red (or blood) orange (Citrus sinensis (L.) Osbeck) is a pigmented sweet orange variety typical of eastern Sicily (southern Italy), California, and Spain. In this paper, we discuss the main health-related properties of the red orange that include anticancer, anti-inflammatory, and cardiovascular protection activities. Moreover, the effects on health of its main constituents (namely, flavonoids, carotenoids, ascorbic acid, hydroxycinnamic acids, and anthocyanins) are described. The red orange juice demonstrates an important antioxidant activity by modulating many antioxidant enzyme systems that efficiently counteract the oxidative damage which may play an important role in the etiology of numerous diseases, such as atherosclerosis, diabetes, and cancer. The beneficial effects of this fruit may be mediated by the synergic effects of its compounds. Thus, the supply of natural antioxidant compounds through a balanced diet rich in red oranges might provide protection against oxidative damage under differing conditions and could be more effective than, the supplementation of an individual antioxidant.

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“…Its leaves are consumed worldwide in different food preparations including as vegetables and as an ingredient of salads. It is reported to be one of the most nutritionally adequate foods and can provide ≥20% (100 g fresh weight basis) of the recommended dietary intake (RDI) of minerals (magnesium, manganese, and iron), phylloquinone (vitamin K 1 ), ascorbic acid (vitamin C), α-tocopherol (vitamin E), carotene (β-carotene and lutein), and folate (vitamin B 9 ). − Earlier studies have reviewed the possible benefits of spinach in different health concerns such as eye disorders, viral infections, oxidative stress, and iron deficiency and also in the context of diabetes, cancer, and hepatotoxicity. , Although spinach has also been illustrated to have antimutagenic activity in some earlier papers, its bioactive phytochemicals have not been isolated and properly characterized. − …”

Section: Introductionmentioning

confidence: 99%

Purification and Characterization of the Principal Antimutagenic Bioactive as Ethoxy-Substituted Phylloquinone from Spinach (Spinacea oleracea L.) Based on Evaluation in Models Including Human Lymphoblast TK^+/– Cells

Kumar

Chatterjee

Tripathi

et al. 2016

J. Agric. Food Chem.

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During in vitro analysis, spinach (Spinacea oleracea L.) leaf extracts displayed varying antimutagenicity when analyzed in models including human lymphoblast (TK) cell line (thymidine kinase gene mutation assay) and Escherichia coli MG1655 (rifampicin resistance assay) against chemically (ethyl methanesulfonate and 5-azacytidine) induced mutagenicity. Highest antimutagenicity was displayed by the quinone extract. The principal bioactive compound exhibited fluorescence in TLC at 366 nm (termed C4) resolved at R 0.32 and t 15.2 min in TLC and HPLC, respectively. On the TLC plate, three spots (C1-C3), observed at 254 nm, displayed comparatively lesser antimutagenicity. Furthermore, biochemical and spectroscopic analyses using MALDI-TOF MS and NMR indicated the nature of the potent compound (C4) as an ethoxy-substituted phylloquinone derivative [2-ethoxy-3-((E)-3,7,11,15-tetramethylhexadec-2-enyl)naphthalene-1,4-dione]. The C4 compound did not display any cytotoxicity and hence possesses significant nutraceutical-based intervention possibility to combat the onset of mutation-associated disease(s).

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In vitro effect of vegetable and fruit juices on the mutagenicity of 2-amino-3-methylimidazo[4,5-f]quinoline, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline

Cited by 59 publications

References 34 publications

Analyzing Biological Properties of Some Plum Genotypes Grown in Turkey

Analyzing Biological Properties of Some Plum Genotypes Grown in Turkey

Red Orange: Experimental Models and Epidemiological Evidence of Its Benefits on Human Health

Purification and Characterization of the Principal Antimutagenic Bioactive as Ethoxy-Substituted Phylloquinone from Spinach (Spinacea oleracea L.) Based on Evaluation in Models Including Human Lymphoblast TK^+/– Cells

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In vitro effect of vegetable and fruit juices on the mutagenicity of 2-amino-3-methylimidazo[4,5-f]quinoline, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline

Cited by 59 publications

References 34 publications

Analyzing Biological Properties of Some Plum Genotypes Grown in Turkey

Analyzing Biological Properties of Some Plum Genotypes Grown in Turkey

Red Orange: Experimental Models and Epidemiological Evidence of Its Benefits on Human Health

Purification and Characterization of the Principal Antimutagenic Bioactive as Ethoxy-Substituted Phylloquinone from Spinach (Spinacea oleracea L.) Based on Evaluation in Models Including Human Lymphoblast TK+/– Cells

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Purification and Characterization of the Principal Antimutagenic Bioactive as Ethoxy-Substituted Phylloquinone from Spinach (Spinacea oleracea L.) Based on Evaluation in Models Including Human Lymphoblast TK^+/– Cells