In vitro effect of zinc on superoxide anion production by polymorphonuclear leukocytes of diabetic patients

Gavella, Mirjana; Lipovac, Vaskrsenija; Car, Antuanet

doi:10.1007/s005920070016

Cited by 7 publications

(4 citation statements)

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“…Additionally, zinc regulates the release of proinflammatory cytokines such as IL-1␤, IL-6, and TNF-␣ by innate immune cells (181)(182)(183). It regulates neutrophil function by modulating the oxidative burst (184,185). As a result, zinc deficiency leads to thymic atrophy, lymphopenia, a reduced CD4/CD8 ratio, and a reduced synthesis of Th1 cytokines.…”

Section: Micronutrients In Immune Function and Host Defensementioning

confidence: 99%

Impact of Childhood Malnutrition on Host Defense and Infection

et al. 2017

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The global impact of childhood malnutrition is staggering. The synergism between malnutrition and infection contributes substantially to childhood morbidity and mortality. Anthropometric indicators of malnutrition are associated with the increased risk and severity of infections caused by many pathogens, including viruses, bacteria, protozoa, and helminths. Since childhood malnutrition commonly involves the inadequate intake of protein and calories, with superimposed micronutrient deficiencies, the causal factors involved in impaired host defense are usually not defined. This review focuses on literature related to impaired host defense and the risk of infection in primary childhood malnutrition. Particular attention is given to longitudinal and prospective cohort human studies and studies of experimental animal models that address causal, mechanistic relationships between malnutrition and host defense. Protein and micronutrient deficiencies impact the hematopoietic and lymphoid organs and compromise both innate and adaptive immune functions. Malnutrition-related changes in intestinal microbiota contribute to growth faltering and dysregulated inflammation and immune function. Although substantial progress has been made in understanding the malnutrition-infection synergism, critical gaps in our understanding remain. We highlight the need for mechanistic studies that can lead to targeted interventions to improve host defense and reduce the morbidity and mortality of infectious diseases in this vulnerable population.

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Section: Micronutrients In Immune Function and Host Defensementioning

confidence: 99%

Impact of Childhood Malnutrition on Host Defense and Infection

et al. 2017

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“…Zinc also may modulate the oxidative burst that is generated by PMNs as part of their microbicidal activity. Stimulated PMNs released lower levels of superoxide anion (O 2 − ) in the presence of 20 μmol extracellular zinc compared to untreated cells; in contrast, PMNs exposed to 200 μmol zinc generated higher O 2 − levels [63]. Substantial evidence implicates a pathogenic role for PMN-derived oxygen metabolites in a range of disorders that are associated with perturbed zinc homeostasis and oxidative stress, including myocardial injury and arrhythmias during ischaemia and reperfusion [15,64].…”

Section: Immune Cellsmentioning

confidence: 99%

Zinc and Regulation of Inflammatory Cytokines: Implications for Cardiometabolic Disease

2012

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In atherosclerosis and diabetes mellitus, the concomitant presence of low-grade systemic inflammation and mild zinc deficiency highlights a role for zinc nutrition in the management of chronic disease. This review aims to evaluate the literature that reports on the interactions of zinc and cytokines. In humans, inflammatory cytokines have been shown both to up- and down-regulate the expression of specific cellular zinc transporters in response to an increased demand for zinc in inflammatory conditions. The acute phase response includes a rapid decline in the plasma zinc concentration as a result of the redistribution of zinc into cellular compartments. Zinc deficiency influences the generation of cytokines, including IL-1β, IL-2, IL-6, and TNF-α, and in response to zinc supplementation plasma cytokines exhibit a dose-dependent response. The mechanism of action may reflect the ability of zinc to either induce or inhibit the activation of NF-κB. Confounders in understanding the zinc-cytokine relationship on the basis of in vitro experimentation include methodological issues such as the cell type and the means of activating cells in culture. Impaired zinc homeostasis and chronic inflammation feature prominently in a number of cardiometabolic diseases. Given the high prevalence of zinc deficiency and chronic disease globally, the interplay of zinc and inflammation warrants further examination.

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“…Minerals, such as zinc (Zn) or selenium (Se; structural component of glutathione peroxidase, GPx), have been associated with semen quality in humans due to their antioxidant properties [Bedwal and Bahuguna 1994;Bjorndahl and Kvist 2010;Chia et al 2000;Gavella et al 2000;Powell 2000]. Furthermore, Zn is included in the WHO manual as an indicator of prostatic function [WHO 2010] and low levels of Zn have been found in SP of infertile men [Chia et al 2000;Colagar et al 2009].…”

Section: Introductionmentioning

confidence: 99%

Boar seminal plasma components and their relation with semen quality

Rodriguez

Rijsselaere

Beek

et al. 2012

Systems Biology in Reproductive Medicine

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Select boar seminal plasma (SP) components and their relation to semen quality were investigated. Thirty nine boars from three artificial insemination (AI) centers were divided into group A (GA: > 80% normal sperm and >70% motility) and group B (GB: < 80% normal sperm and < 70% motility). Each ejaculate was collected and semen volume, concentration, sperm motility (computer aided semen analysis; CASA), morphology, and vitality (both eosin nigrosin staining) were investigated. The SP was separated and analyzed for aspartate-amino-transferase (AST), γ-glutamyl-transferase (GGT), alkaline phosphatase (ALP) activity, and the concentrations of sodium (Na), potassium (K), chloride (Cl), calcium (Ca), phosphate (PO 4 3-), magnesium (Mg), selenium (Se) and zinc (Zn) were assessed. Repeated measures (2 months interval) were conducted in eight boars of GA from one AI center. The activity of GGT (r = -0.482) and ALP (r = -0.459) was moderately associated ( p < 0.05) with ejaculate volume and strongly associated with concentration (r = 0.580 and r = 0.618, respectively; p = 0.000). Moderate associations ( p < 0.05) were found between ALP (r = 0.439), GGT (r = 0.387), Na (r = -0.428), K (r = 0.354), and Se (r = 0.354) with progressive motility. The SP concentration of Na (r = -0.401), Cl (r = -0.521), and K (r = 0.350) was associated ( p < 0.05) with normal morphology. Only Mg was associated ( p < 0.05) with membrane damage (r = -0.335). The concentration of Na, Cl, and Zn (1681.0 vs. 1701.0 µg/dL) was different between groups ( p < 0.05). Repeated measures showed significant differences in time but only for Na, Mg, and Zn ( p < 0.05). In conclusion, several biochemical components of SP were related to semen quality. The analysis of biochemical parameters could provide extra information about reproductive health of AI boars.

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In vitro effect of zinc on superoxide anion production by polymorphonuclear leukocytes of diabetic patients

Cited by 7 publications

References 0 publications

Impact of Childhood Malnutrition on Host Defense and Infection

Impact of Childhood Malnutrition on Host Defense and Infection

Zinc and Regulation of Inflammatory Cytokines: Implications for Cardiometabolic Disease

Boar seminal plasma components and their relation with semen quality

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