In vitro effects and mechanisms of action of Bidens pilosa in Trypanosoma brucei

Dofuor, Aboagye Kwarteng; Djameh, Georgina Isabella; Amoa-Bosompem, Michael; Kwain, Samuel; Osei, Evelyn; Tetevi, Gilbert Mawuli; Ayertey, Frederick; Bolah, Peter; Okine, Laud Kenneth; Kyeremeh, Kwaku; Gwira, Theresa Manful; Ohashi, Mitsuko

doi:10.1016/j.jtcme.2021.08.008

Cited by 4 publications

(1 citation statement)

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“…Notably, B. pilosa exhibits antitrypanosomal properties, particularly through the identification of butyl and propyl compounds of tryptophan. These compounds have been found to effectively inhibit the cell cycle of Trypanosoma brucei in Africa [ 9 ]. Despite being considered a weed in the main crops, various studies have been conducted on the microfauna associated with its rhizosphere.…”

Section: Introductionmentioning

confidence: 99%

Exploring Genomics and Microbial Ecology: Analysis of Bidens pilosa L. Genetic Structure and Soil Microbiome Diversity by RAD-Seq and Metabarcoding

Reyes-Ardila,

Rugeles-Silva,

Duque-Zapata

et al. 2024

Plants

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Bidens pilosa L., native to South America and commonly used for medicinal purposes, has been understudied at molecular and genomic levels and in its relationship with soil microorganisms. In this study, restriction site-associated DNA markers (RADseq) techniques were implemented to analyze genetic diversity and population structure, and metabarcoding to examine microbial composition in soils from Palmira, Sibundoy, and Bogotá, Colombia. A total of 2,984,123 loci and 3485 single nucleotide polymorphisms (SNPs) were identified, revealing a genetic variation of 12% between populations and 88% within individuals, and distributing the population into three main genetic groups, FST = 0.115 (p < 0.001) and FIT = 0.013 (p > 0.05). In the soil analysis, significant correlations were found between effective cation exchange capacity (ECEC) and apparent density, soil texture, and levels of Mg and Fe, as well as negative correlations between ECEC and Mg, and Mg, Fe, and Ca. Proteobacteria and Ascomycota emerged as the predominant bacterial and fungal phyla, respectively. Analyses of alpha, beta, and multifactorial diversity highlight the influence of ecological and environmental factors on these microbial communities, revealing specific patterns of clustering and association between bacteria and fungi in the studied locations.

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Section: Introductionmentioning

confidence: 99%