In vitro effects of 50 Hz magnetic fields on oxidatively damaged rabbit red blood cells

Fiorani, Mara; Biagiarelli, Beatrice; Vetrano, F.; Guidi, G. M.; Dachà, Marina; Stocchi, Vilberto

doi:10.1002/(sici)1521-186x(1997)18:2<125::aid-bem5>3.0.co;2-4

Cited by 41 publications

(11 citation statements)

References 37 publications

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“…It can effectively improve symptoms pertaining to nervous system including treatment-resistant depression and multiple sclerosis 20 . EMFs have shown to facilitate the re-establishment of normal potentials in damaged cells 21 ; this property can be suavely exploited in the area of orthopedics in the treatment of non-uniform fractures and failed fusions. In fact, EMF improves osteogenic phase of the healing process 22 by favouring the bone formation and healing through increased blood flow 23 , proliferation, differentiation and maturation of osteoblasts 24 .…”

Section: Effect Of Electromagnetic Field On Biomoleculessupporting

confidence: 61%

Advances in Electromagnetic Therapy for Wound Healing

Madduri¹,

Anand²,

Kohli³

et al. 2018

Def. Life. Sc. Jl.

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Understanding the molecular basis of wound healing and tissue regeneration continues to remain as one of the major challenges in modern medicine. Wound healing is a complex procedure involving various cellular mechanism. Though high frequency electromagnetic fields are reported to cause cancer, birth defects and DNA damage, electromagnetic field at low intensity and low frequency can be effectively used for wound healing and for many more medical applications. Low intensity-low frequency pulsed electromagnetic therapy is evidenced to have a significant impact on wound repair and regeneration. It provides a non-invasive reparative technique to treat an injury. In vitro studies reported a significant effect of electromagnetic field on neovascularisation and angiogenesis. There are also many pieces of evidence which support its efficiency in reducing the duration of wound healing and improving the tensile strength of scars. Here, we compared the traditional stigma associated with pulsed electromagnetic fields and weighed them with its potential therapeutic effect on wound healing. Furthermore, emphasised the need for more focused research to determine the therapeutic strategies and optimised parameters of pulsed electromagnetic field that can assure efficient wound healing and regeneration.

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Section: Effect Of Electromagnetic Field On Biomoleculessupporting

confidence: 61%

Advances in Electromagnetic Therapy for Wound Healing

Madduri¹,

Anand²,

Kohli³

et al. 2018

Def. Life. Sc. Jl.

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“…Effects of magnetic fields on cellular kinetics of free radicals (Eveson et al 2000;Khadir et al 1999;Roy et al 1995) and free radical-related cellular processes (Fiorani et al 1997;Katsir and Parola 1998) have been reported. Free radical-induced damage to DNA could have important effects on health (Beckman and Ames 1997).…”

Section: Discussionmentioning

confidence: 96%

Magnetic-field-induced DNA strand breaks in brain cells of the rat.

Lai

Singh

2004

Environ Health Perspect

281

173

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In previous research, we found that rats acutely (2 hr) exposed to a 60-Hz sinusoidal magnetic field at intensities of 0.1-0.5 millitesla (mT) showed increases in DNA single-and double-strand breaks in their brain cells. Further research showed that these effects could be blocked by pretreating the rats with the free radical scavengers melatonin and N-tert-butyl-α-phenylnitrone, suggesting the involvement of free radicals. In the present study, effects of magnetic field exposure on brain cell DNA in the rat were further investigated. Exposure to a 60-Hz magnetic field at 0.01 mT for 24 hr caused a significant increase in DNA single-and double-strand breaks. Prolonging the exposure to 48 hr caused a larger increase. This indicates that the effect is cumulative. In addition, treatment with Trolox (a vitamin E analog) or 7-nitroindazole (a nitric oxide synthase inhibitor) blocked magnetic-field-induced DNA strand breaks. These data further support a role of free radicals on the effects of magnetic fields. Treatment with the iron chelator deferiprone also blocked the effects of magnetic fields on brain cell DNA, suggesting the involvement of iron. Acute magnetic field exposure increased apoptosis and necrosis of brain cells in the rat. We hypothesize that exposure to a 60-Hz magnetic field initiates an iron-mediated process (e.g., the Fenton reaction) that increases free radical formation in brain cells, leading to DNA strand breaks and cell death. This hypothesis could have an important implication for the possible health effects associated with exposure to extremely low-frequency magnetic fields in the public and occupational environments.

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“…Also, free oxygen radicals that produced after exposure to MFs acting as oxidizing agents and able to increase cellular damage [28] and cause decomposition of membranes with leakage of damaging lysosomal hydrolytic enzymes [29]. Similar apoptotic changes were detected in liver cells after exposure to EMFs and explained by decreased tissue concentration of glutathione enzyme [30].…”

Section: Resultsmentioning

confidence: 96%