In vitro effects of combinations of antipseudomonal agents against seven strains of multidrug-resistant Pseudomonas aeruginosa

Oie, Shigeharu; Uematsu, Taro; Sawa, Akihiro; Mizuno, Hidekazu; Tomita, Masaaki; Ishida, Shiro; Okano, Yoshiro; Kamiya, Akira

doi:10.1093/jac/dkg478

Cited by 23 publications

(23 citation statements)

References 20 publications

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“…Okazaki et al have investigated effectiveness of phosphomycin combination against MDRP by the efficacy time index [10]. Oie et al have reported that the combination of AZT and amikacin was the most effective, inhibiting proliferation in MDRP [11]. Our data also suggested synergistic effects of GM, especially in combination with AZT and PIPC.…”

Section: Methodssupporting

confidence: 62%

‘Break-point Checkerboard Plate’ for screening of appropriate antibiotic combinations against multidrug-resistant Pseudomonas aeruginosa

Tateda

Ishii

Matsumoto

et al. 2006

Scandinavian Journal of Infectious Diseases

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Increase of multiple drug resistant Pseudomonas aeruginosa (MDRP) is becoming a serious problem in the clinical setting. Although the checkerboard method to determine FIC index and synergistic effects of antibiotic combinations is useful, it is not well adapted to a routine test, mainly because of its time-consuming and labor-intensive nature. Here we report 'Break-point Checkerboard Plate', in which breakpoint concentrations, such as 'S' (sensitive) and 'I' (intermediate), were combined in a microtiter plate with 8 antibiotics, including carbapenem, aminoglycoside and fluoroquinolone. The results obtained from 12 strains of MDRP demonstrated a strong synergistic effect of some antibiotic combinations at clinically relevant concentrations. Our data suggest a usefulness of 'Break-point Checkerboard Plate' to screen appropriate antibiotic combinations against drug resistant organisms, including MDRP.

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Section: Methodssupporting

confidence: 62%

‘Break-point Checkerboard Plate’ for screening of appropriate antibiotic combinations against multidrug-resistant Pseudomonas aeruginosa

Tateda

Ishii

Matsumoto

et al. 2006

Scandinavian Journal of Infectious Diseases

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“…A number of in vitro studies have demonstrated a synergistic activity against MDRP strains when colistin is combined with rifampicin [14,15] or with amikacin [16,17]. However, no clinical studies carried out to date have demonstrated the superiority of combining colistin with other antimicrobials over monotherapy [18].…”

Section: Discussionmentioning

confidence: 99%

“…This study was presented at the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Mc Cormick Place Lakeside Center, Chicago, Illinois, that was held on September [17][18][19][20] 2007.…”

mentioning

confidence: 99%

Effectiveness and safety of colistin for the treatment of multidrug-resistant Pseudomonas aeruginosa infections

et al. 2009

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“…Several authors prefer combination regimens for the treatment of serious S. maltophilia infection, particularly in individuals immunocompromised because of the bacteriostatic mode of action of most agents and the potential for the development of resistance during monotherapy [56]. Strategies for salvage therapy of MDR P. aeruginosa infection include combining agents that individually have limited activity against the organism [74][75][76]. Similar strategies might be useful for the treatment of S. maltophilia infection.…”

Section: Treatment Considerationsmentioning

confidence: 99%

Stenotrophomonas maltophilia: Changing Spectrum of a Serious Bacterial Pathogen in Patients with Cancer

Safdar

Rolston²

2007

Clinical Infectious Diseases

204

125

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Stenotrophomonas maltophilia colonization/infection in patients with cancer has significantly increased over the past 2 decades. Patients with prolonged neutropenia, exposure to broad-spectrum antibiotics, and those requiring mechanical ventilation have higher risk of infection. These micro-organisms are intrinsically resistant to carbapenems, and exposure to these agents has been linked to selection of S. maltophilia. Recently, these infections are being documented in patients without traditional risk factors. The spectrum of infection includes bacteremia, catheter-related infection, pneumonia, complicated biliary and urinary tract infection, and skin and skin-structure infection. Trimethoprim-sulfamethoxazole is the therapeutic agent of choice, but resistance is increasingly being reported. Susceptibility to alternative agents is unpredictable. Combination therapy and alternative routes of drug administration, such as aerosolized aminoglycoside, might be necessary. New insights into the mechanisms of drug resistance might lead to identification of new target sites. Agents that improve outer-membrane permeability and broad-spectrum beta-lactamase inhibitors may favorably impact difficult-to-treat (i.e., multidrug resistant) S. maltophilia infections.

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In vitro effects of combinations of antipseudomonal agents against seven strains of multidrug-resistant Pseudomonas aeruginosa

Abstract: The three-drug combination of ceftazidime, aztreonam and amikacin may be effective against P. aeruginosa resistant to all commonly used antipseudomonal drugs, and deserves further study.

Cited by 23 publications

References 20 publications

‘Break-point Checkerboard Plate’ for screening of appropriate antibiotic combinations against multidrug-resistant Pseudomonas aeruginosa

‘Break-point Checkerboard Plate’ for screening of appropriate antibiotic combinations against multidrug-resistant Pseudomonas aeruginosa

Effectiveness and safety of colistin for the treatment of multidrug-resistant Pseudomonas aeruginosa infections

Stenotrophomonas maltophilia: Changing Spectrum of a Serious Bacterial Pathogen in Patients with Cancer

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