In vitro effects of Coriandrum sativum, Tagetes minuta, Alpinia zerumbet and Lantana camara essential oils on Haemonchus contortus

Macedo, Iara Térsia Freitas; Oliveira, Lorena Mayana Beserra de; Camurça-Vasconcelos, A.L.F.; Ribeiro, Wesley Lyeverton Correia; Santos, J. M. L. dos; Morais, Selene Maia de; Paula, Haroldo C.B.; Beviláqua, Cláudia Maria Leal

doi:10.1590/s1984-29612013000400004

Cited by 31 publications

(30 citation statements)

References 43 publications

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“…O RCOF estima a eficácia anti-helmíntica de um produto pela comparação da contagem de ovos nas fezes antes e após o tratamento [90]. Experimentos constataram redução na eliminação de ovos nas fezes (OPG) e/ou na carga parasitária de pequenos ruminantes após a administração de OE [8,53,57,62]. Os principais resultados obtidos em testes in vivo com OE estão na Tabela 2.…”

Section: Efeito Anti-helmíntico De óLeos Essenciaisunclassified

Essential Oils and Their Bioactive Compounds in the Control of Gastrointestinal Nematodes of Small Ruminants

André

Ribeiro

Oliveira

et al. 2018

Acta Scientiae. Vet.

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Background: Gastrointestinal nematodes are one of the major health and economic problem of sheep and goats in the world. The control of these nematodes is carried out conventionally with synthetic anthelminths, which favored the selection of gastrointestinal nematode (GIN) populations multiresistant to anthelmintics. The emergence of anthelmintic resistance has stimulated the search for new alternatives to control small ruminant GIN, standing out the use of plants and their bioactives compounds, such as essential oils (EO). The objective of this review was to present the main characteristics and anthelmintic activity of EO, their isolated compounds and drug delivery systems in the control of GIN.Review: Essential oils are a complex blend of bioactive compounds with volatile, lipophilic, usually odoriferous and liquid substances. EO are composed of terpenes, terpenoids, aromatic and aliphatic constituents. EO has various pharmacological activities of interest in preventive veterinary medicine such as antibacterials, antifungals, anticoccicids, insecticides and anthelmintics. In vitro and in vivo tests are used to validate the anthelmintic activity of EO on GIN. In vitro tests are low cost screening tests that allow the evaluation of the anthelmintic activity of a large amount of bioactive compounds on eggs, first (L1) and third stage larvae (L3), and adult nematodes. The antiparasitic effect of EO is related to its main compound or to the interaction of the compounds. These bioactive compounds penetrate the cuticle of the nematodes by transcuticular diffusion, altering the mechanisms of locomotion, besides causing cuticular lesions. Following in vitro evaluation, the acute and sub-chronic toxicity test should be performed to assess the toxicity of the bioactive compounds and to define the dose to be used in in vivo tests. In vivo tests are more reliable because the anthelmintic effectiveness of bioactive compounds is evaluated after the metabolization process. The metabolization process of the bioactive compounds can generate metabolites that exhibit or not anthelmintic effectiveness. The in vivo tests assessing the anthelmintic effectiveness of bioactive compounds in sheep and goats are the fecal egg count reduction test and the controlled test. OE promoted reduction of egg elimination in faeces which may be related to cuticular and reproductive alterations in GIN, and reduction of parasite burden in in vivo tests. Due to the promising results obtained with OE in the in vivo tests, interest has been aroused in using nanotechnology as an alternative to increase the bioavailability of OE and consequently, potentializing its anthelmintic effect, reducing the dose and toxicity of the biocompounds. In addition to nanotechnology, the isolation and chemical modification of compounds isolated from OE have been employed to obtain new molecules with anthelmintic action and understand the mechanism of action of EO on the small ruminant GIN.Conclusion: The use of EO and their compound bioactive in the control of resistant populations of GIN is a promising alternative. The adoption of strategies in which natural products can replace synthetic anthelmintics, such as in dry periods and use synthetic anthelmintics in the rainy season when the population in refugia in the pasture is high, thus reducing the dissemination of GIN resistant populations. As perspective, the evaluation of pharmacokinetics and pharmacodynamics of these natural products should be performed so that one defines treatment protocols that optimize the anthelmintic effect.

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Section: Efeito Anti-helmíntico De óLeos Essenciaisunclassified

Essential Oils and Their Bioactive Compounds in the Control of Gastrointestinal Nematodes of Small Ruminants

André

Ribeiro

Oliveira

et al. 2018

Acta Scientiae. Vet.

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“…The effective concentration to inhibit 50% (EC 50 ) of egg hatching was 0.63 mg/ml. In LDT, Coriandrum sativum at concentration of 10 mg/ml inhibited 97.8% of H. contortus larval development [104].…”

Section: Antibacterial Antifungal Anthelmintic and Insecticidal Effmentioning

confidence: 96%

A review on chemical constituents and pharmacological activities of Coriandrum sativum

Al-Snafi¹

2016

IOSRPHR

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Abstract:-The phytochemical screening of Coriandrum sativum showed that it contained essential oil, tannins, terpenoids, reducing sugars, alkaloids, phenolics, flavonoids, fatty acids, sterols and glycosides. It also contained high nutritional values including proteins, oils, carbohydrates, fibers and wide range of minerals, trace elements and vitamins. The previous pharmacological studies revealed that it possessed anxiolytic, antidepressant, sedative-hypnotic, anticonvulsant, memory enhancement, improvement of orofacial dyskinesia, neuroprotective, antibacterial, antifungal, anthelmintic, insecticidal, antioxidant, cardiovascular, hypolipidemic, anti-inflammatory, analgesic, antidiabetic, mutagenic, antimutagenic, anticancer, gastrointestinal, deodorizing, dermatological, diuretic, reproductive, hepatoprotective, detoxification and many other pharmacological effects. The current review was designed to give an overview on the chemical constituents and pharmacological effects of Coriandrum sativum.

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Section: Coriandrum Sativummentioning

confidence: 96%

Antiparasitic, antiprotozoal, molluscicidal and insecticidal activity of medicinal plants (part 2) – plant based review

Al-Snafi¹

2016

SAJP

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In vitro effects of Coriandrum sativum, Tagetes minuta, Alpinia zerumbet and Lantana camara essential oils on Haemonchus contortus

Cited by 31 publications

References 43 publications

Essential Oils and Their Bioactive Compounds in the Control of Gastrointestinal Nematodes of Small Ruminants

Essential Oils and Their Bioactive Compounds in the Control of Gastrointestinal Nematodes of Small Ruminants

A review on chemical constituents and pharmacological activities of Coriandrum sativum

Antiparasitic, antiprotozoal, molluscicidal and insecticidal activity of medicinal plants (part 2) – plant based review

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