In vitro effects of different formulations of bovine collagen on cultured human skin

Trasciatti, Silvia; Podestà, Adriano; Bonaretti, Silvano; Mazzoncini, Viviano; Rosini, S

doi:10.1016/s0142-9612(97)00175-0

Cited by 14 publications

(14 citation statements)

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“…Using artificial skin substitutes for repairing avoids the complications of the grafts, but a perfect material for a scaffold which is strong and allows the regeneration of the skin tissue has to be found [35]. Some existing scaffolds are made from collagen or gelatine, which are appropriate for promoting the tissue regeneration, but they are not mechanically strong [139]. Others, which are made from biodegradable synthetic materials such as poly(L-lactic acid) (PLLA), are stronger, but not so suitable for the tissue growth [140,141].…”

Section: Plla-collagenmentioning

confidence: 99%

Recent advances on biomedical applications of scaffolds in wound healing and dermal tissue engineering

Bakhshayesh

Annabi

Khalilov

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

193

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The tissue engineering field has developed in response to the shortcomings related to the replacement of the tissues lost to disease or trauma: donor tissue rejection, chronic inflammation and donor tissue shortages. The driving force behind the tissue engineering is to avoid the mentioned issues by creating the biological substitutes capable of replacing the damaged tissue. This is done by combining the scaffolds, cells and signals in order to create the living, physiological, three-dimensional tissues. A wide variety of skin substitutes are used in the treatment of full-thickness injuries. Substitutes made from skin can harbour the latent viruses, and artificial skin grafts can heal with the extensive scarring, failing to regenerate structures such as glands, nerves and hair follicles. New and practical skin scaffold materials remain to be developed. The current article describes the important information about wound healing scaffolds. The scaffold types which were used in these fields were classified according to the accepted guideline of the biological medicine. Moreover, the present article gave the brief overview on the fundamentals of the tissue engineering, biodegradable polymer properties and their application in skin wound healing. Also, the present review discusses the type of the tissue engineered skin substitutes and modern wound dressings which promote the wound healing.

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Section: Plla-collagenmentioning

confidence: 99%

Recent advances on biomedical applications of scaffolds in wound healing and dermal tissue engineering

Bakhshayesh

Annabi

Khalilov

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

193

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“…Skin tissue engineering by using cultured fibroblasts and keratinocyte to treat skin defects has been developed as a challenging method for wound healing [2,3]. In this approach, a temporary scaffold serves as support for culture of fibroblasts and keratinocytes to construct three-dimensional (3D) skin architecture [4].…”

Section: Introductionmentioning

confidence: 99%

“…In both clinical and preclinical models, collagen and gelatin are the most commonly used scaffolding materials owing to their advantageous properties, including low antigenicity and promotion of cell adhesion and proliferation [4]. However, the problem that compromises the effect of collagen-and gelatin-based scaffolds is low mechanical strength.…”

Section: Introductionmentioning

confidence: 99%

PLLA–collagen and PLLA–gelatin hybrid scaffolds with funnel-like porous structure for skin tissue engineering

Naoki

et al. 2012

Science and Technology of Advanced Materials

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In skin tissue engineering, a three-dimensional porous scaffold is necessary to support cell adhesion and proliferation and to guide cells moving into the repair area in the wound healing process. Structurally, the porous scaffold should have an open and interconnected porous architecture to facilitate homogenous cell distribution. Moreover, the scaffolds should be mechanically strong to protect deformation during the formation of new skin. In this study, the hybrid scaffolds were prepared by forming funnel-like collagen or gelatin sponge on a woven poly(l-lactic acid) (PLLA) mesh. The hybrid scaffolds combined the advantages of both collagen or gelatin (good cell-interactions) and PLLA mesh (high mechanical strength). The hybrid scaffolds were used to culture dermal fibroblasts for dermal tissue engineering. The funnel-like porous structure promoted homogeneous cell distribution and extracellular matrix production. The PLLA mesh reinforced the scaffold to avoid deformation. Subcutaneous implantation showed that the PLLA-collagen and PLLA-gelatin scaffolds promoted the regeneration of dermal tissue and epidermis and reduced contraction during the formation of new tissue. These results indicate that funnel-like hybrid scaffolds can be used for skin tissue regeneration.

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“…São diversas as aplicações clínicas do colágeno, como por exemplo: no sistema para liberação controlada de drogas (drug delivery system), como matrizes carreadoras na Engenharia de Tecidos, como materiais de preenchimento no reparo ósseo, como agente hemostático, na confecção de enxertos para as mais diversas especialidades médicas como, por exemplo no tratamento de queimaduras, como barreira física na regeneração tecidual guiada. (3,29,30,31,32,33) Os benefícios de utilizar esse material absorvível incluem a promoção da cura da ferida através da fixação do coágulo, estabilização da ferida e homeostase. A membrana de colágeno, também promove o aumento primário da cicatrização da ferida através de sua habilidade quimiotática de atrair fibroblastos.…”

Section: Absorvíveisunclassified

O Uso De Membranas Biológicas Para Regeneração Óssea Guiada Em Implantodontia: Uma Revisão De Literatura

et al. 2016

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The significant development of biomaterials for use in clinical dentistry in the last decade has represented a powerful therapeutic tool in surgical activities, especially in the correction of bone defects. The guided tissue regeneration is a surgical practice in which it uses an artificial barrier called a biological membrane that serves as a barrier to epithelial migration to the success of new bone formation in areas of bone defects. Such membranes can be absorbable or not absorbable. This article discusses the use of the technique of guided bone regeneration techniques and the placement, composition, properties, advantages and disadvantages of the materials to be used.

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In vitro effects of different formulations of bovine collagen on cultured human skin

Cited by 14 publications

References 0 publications

Recent advances on biomedical applications of scaffolds in wound healing and dermal tissue engineering

Recent advances on biomedical applications of scaffolds in wound healing and dermal tissue engineering

PLLA–collagen and PLLA–gelatin hybrid scaffolds with funnel-like porous structure for skin tissue engineering

O Uso De Membranas Biológicas Para Regeneração Óssea Guiada Em Implantodontia: Uma Revisão De Literatura

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