1989
DOI: 10.1055/s-0038-1646570
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In Vitro Effects of Ethanol on Rabbit Platelet Aggregation, Secretion of Granule Contents, and Cyclic AMP Levels in the Presence of Prostacyclin

Abstract: SummaryEthanol, at physiologically tolerable concentrations, inhibits platelet responses to low concentrations of collagen or thrombin, but does not inhibit responses of washed rabbit platelets stimulated with high concentrations of ADP, collagen, or thrombin. However, when platelet responses to high concentrations of collagen or thrombin had been partially inhibited by prostacyclin (PGI2), ethanol had additional inhibitory effects on aggregation and secretion. These effects were also observed with aspirin- tr… Show more

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Cited by 28 publications
(13 citation statements)
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“…This effect may be mediated by the inhibition of phospholipase A 2 , which reduces arachadonic acid release from platelet membranes and decreases thromboxane A 2 production. 44 45 We did not summarise the effects of alcohol on platelet aggregation owing to large differences in assay methods, but if the effects are causal the subsequent impact on reduced risk of coronary heart disease may be substantial. 46 47…”
Section: Methodsmentioning
confidence: 99%
“…This effect may be mediated by the inhibition of phospholipase A 2 , which reduces arachadonic acid release from platelet membranes and decreases thromboxane A 2 production. 44 45 We did not summarise the effects of alcohol on platelet aggregation owing to large differences in assay methods, but if the effects are causal the subsequent impact on reduced risk of coronary heart disease may be substantial. 46 47…”
Section: Methodsmentioning
confidence: 99%
“…Resveratrol and other polyphenolic compounds decrease platelet aggregation, possibly by interfering with prostaglandin synthesis and ADP-mediated aggregation (28,72,112). Similarly, ethanol inhibits in vitro platelet secretion and aggregation, in part by inhibiting phospholipase A 2 secretion and activity (74,95). In vivo, platelet aggregation was inhibited after healthy human volunteers consumed purple grape juice, suggesting grapederived flavonoids and not just ethanol, may contribute to the apparent antithrombotic effect of red wine (36) (see Fig.…”
Section: Plaque Destabilization Rupture and Thrombosismentioning
confidence: 99%
“…The extent of platelet aggregation (expressed as a percentage) was indicated by the maximum increase in light transmission 3 minutes after the addition of ADP or 5 minutes after addition of SFLLRN. 35 All concentrations reported are final concentrations after all additions to the platelet suspensions.…”
Section: Aggregation Of Plateletsmentioning
confidence: 99%