In vitro effects of famotidine and ranitidine on lower esophageal sphincter tone in rats

Özer, Mahmut; Duman, Mustafa; Taş, Şükrü; Demırcı, Yeliz; Aydın, Muhammet Fatih; Reyhan, Enver; Atici, Ali Emre; Bostancı, Erdal Birol; Akoğlu, Musa; Genç, Ece

doi:10.4318/tjg.2012.0448

Cited by 2 publications

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the ranitidine group (n = 4), after the surgical procedure to prevent development of esophagitis, the rats were treated with ranitidine, a histamine H2 receptor antagonist group antacid (14), at 0.5 mg kg -1 day -1…”

Section: Methodsmentioning

confidence: 99%

Expression of NADPH-d in the vagal nuclei of the chronic esophagitis model in rats

Doshi

Srivastava²

2014

Turk J Med Sci

View full text Add to dashboard Cite

Agricultural biomass is the world's largest, most sustainable, and most promising renewable energy source. This study investigated the potential of Karanja (Pongamia pinnata) oilseed residual waste (defatted kernel, hull, and their mixture) as a source of ethanol. The pretreatment of the finely ground samples was carried out using dilute sulfuric acid (0.5%) hydrolysis at a higher temperature of 121 °C and 15 psi pressure for 90 min. The pretreatment usually removes the lignin and facilitates the hydrolysis of cellulose and hemicelluloses. They were further hydrolyzed using 5% H 2 SO 4 at 50 °C for 70 h. The analyses of hydrolyzed products have shown the presence of 66.06-67.12 mg g -1 of total reducing sugars, 0.41-0.47 mg g -1 of glucose, and 0.36-0.45 mg g -1 of xylose, from which the rate of hydrolysis and conversion percentage of cellulose to glucose (44.44%-55.16%) and hemicelluloses to xylose (53.76%-67.17%) was obtained. The hydrolyzed product of complex polysaccharide was further converted into ethanol by fermentation at 32 °C on an orbital shaker using commercial yeast. The results showed ethanol yield of about 10.3%, 8.3%, and 3.3%, respectively in fermentation broths of kernel, mixture, and hull samples, thus indicating Karanja oilseed wastes as potential sources for ethanol production.

show abstract

Section: Methodsmentioning

confidence: 99%

Expression of NADPH-d in the vagal nuclei of the chronic esophagitis model in rats

Doshi

Srivastava²

2014

Turk J Med Sci

View full text Add to dashboard Cite

show abstract

“…Thus, esomeprazole was selected in the present study. Likewise, famotidine was used as a H2 blocker, because famotidine was superior to ranitidine and cimetidine in inhibition of gastric acid secretion and treatment of GERD (Langtry et al 1989;Wesdorp 1992;Bersenas et al 2005;Ozer et al 2012).…”

Section: Subjects and Study Designmentioning

confidence: 99%

Proton Pump Inhibitor Ameliorates Taste Disturbance among Patients with Laryngopharyngeal Reflux: A Randomized Controlled Study

Suzuki

Yokota

Matsumoto

et al. 2019

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Patients with laryngopharyngeal reflux (LPR) were reported to suffer from hypogeusia that affects quality of life. Proton pump inhibitor (PPI) is a useful drug in the treatment of LPR, but its effect on hypogeusia is not known. We therefore assessed the effects of PPI or a histamine H2 receptor antagonist (H2 blocker) on hypogeusia among patients with LPR. Both PPI and H2 blocker could inhibit acid reflux. LPR was diagnosed with reflux finding score and reflux symptom index. The visual analogue scale (VAS) of taste disturbance symptoms and the gustatory tests were assessed before and 8 weeks after treatment with esomeprazole, a PPI (20 patients, aged 50.0 ± 1.7 years) or famotidine, a H2 blocker (20 patients, aged 47.1 ± 1.8 years). There were no significant differences in VAS scores and recognition thresholds for four basic tastes between the two groups before treatment. Only PPI therapy significantly decreased the VAS scores, suggesting the improvement of taste perception. Moreover, PPI therapy significantly decreased recognition thresholds for bitter taste in the anterior tongue (chorda tympani nerve area) and the thresholds in the posterior tongue (glossopharyngeal nerve area) for salty, sour, and bitter tastes. By contrast, H2-blocker therapy caused no significant changes of thresholds in the anterior tongue, but improved the threshold only for bitter in the posterior tongue, the value of which was however significantly higher than that in PPI group. In conclusion, PPI could ameliorate hypogeusia by improving bitter, salty, and sour tastes among patients with LPR.

show abstract

In vitro effects of famotidine and ranitidine on lower esophageal sphincter tone in rats

Cited by 2 publications

References 38 publications

Expression of NADPH-d in the vagal nuclei of the chronic esophagitis model in rats

Expression of NADPH-d in the vagal nuclei of the chronic esophagitis model in rats

Proton Pump Inhibitor Ameliorates Taste Disturbance among Patients with Laryngopharyngeal Reflux: A Randomized Controlled Study

Contact Info

Product

Resources

About