In vitro effects of Salvia officinalis L. essential oil on Candida albicans

Sookto, Tularat; Srithavaj, Theerathavaj; Thaweboon, Sroisiri; Thaweboon, Boonyanit; Shrestha, Binit

doi:10.1016/s2221-1691(13)60080-5

Cited by 59 publications

(49 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The essential oils and their components, such as linalool, can interfere in the biosynthesis of the cell wall and/or can increase the ionic permeability of the fungal cell membrane (Pierce et al, 2013;Sookto et al, 2013). They may represent an important source of new molecules capable of controlling oral fungal infections.…”

Section: Discussionmentioning

confidence: 99%

Antifungal activity of linalool in cases of Candida spp. isolated from individuals with oral candidiasis

et al. 2017

View full text Add to dashboard Cite

This study analyzed the antifungal activity of phytoconstituents from linalool on Candida spp. strains, in vitro, isolated from patients with clinical diagnoses of oral candidiasis associated with the use of a dental prosthesis. Biological samples were collected from 12 patients using complete dentures or removable partial dentures and who presented mucous with diffuse erythematous or stippled features, indicating a clinical diagnosis of candidiasis. To identify fungal colonies of the genus Candida, samples were plated onto CHROMagar Candida  . The antifungal activity of linalool, a monoterpene unsaturated constituent of basil oil, was performed using the broth microdilution technique. Then, the minimum inhibitory concentration (MIC), the two subsequent stronger concentrations and the positive controls were subcultured on Sabouraud Dextrose Agar plates to determine the minimum fungicidal concentration (MFC). The experiments were performed in triplicate and nystatin was used as a positive control in all tests. Diagnoses of oral candidiasis were verified in eight patients (66.6%) and the most prevalent fungal species was Candida albicans (37.5%), followed by Candida krusei (25.0%); and Candida tropicalis (4.2%). The best antifungal activity of linalool was observed on Candida tropicalis (MIC = 500 mg/mL), followed by Candida albicans (MIC = 1.000 mg/mL), and Candida krusei (MIC = 2.000 mg/mL).Under the study conditions and based on the results obtained, it can be concluded that the Candida strains tested were susceptible to linalool.Keywords: candidiasis, linalool, phytotherapy. Atividade antifúngica do linalol em casos de Candida spp. isolados de indivíduos com candidíase oral ResumoEste estudo analisou a atividade antifúngica do fitoconstituinte linalol em cepas de Candida ssp, in vitro, isolados de pacientes com o diagnóstico clínico de candidíase oral associado ao uso de prótese dentária. As amostras biológicas foram coletadas de 12 pacientes portadores de próteses totais ou próteses parciais removíveis e que apresentavam características de mucosa eritematosa difusa ou pontilhadas, indicando um diagnóstico clínico de candidíase. Para identificar colônias de fungos do gênero Candida, as amostras foram semeadas em CHROMagar Candida  . A atividade antifúngica do linalol, um componente insaturado monoterpene de óleo de manjericão, foi realizada através da técnica de microdiluição em caldo. Em seguida, a concentração inibitória mínima (MIC), as duas concentrações consecutivas mais fortes e os controles positivos foram subcultivados em placas de Agar Sabouraud Dextrose para determinar a concentração fungicida mínima (MFC). Os experimentos foram realizados em triplicata e a nistatina foi usada como controle positivo em todos os testes. O diagnóstico de candidíase oral foi comprovado em oito pacientes (66,6%) e as espécies de fungos mais prevalentes foram Candida albicans (37,5%), seguido por Candida krusei (25,0%); e Candida tropicalis (4,2%). A melhor atividade antifúngica do linalol foi observada em Candi...

show abstract

Section: Discussionmentioning

confidence: 99%

Antifungal activity of linalool in cases of Candida spp. isolated from individuals with oral candidiasis

et al. 2017

View full text Add to dashboard Cite

show abstract

“…With these results, the authors pointed out S. officinalis as natural alternative for the treatment of candidiasis. Sookto et al 27 also assessed the activity of the essential oil of S. officinalis on C. albicans and observed the formation of inhibition halos of 19.5 to 40.5 mm and MIC of 2.780 g/L, confirming the antifungal activity against yeast. It is highlighted that the results found in in vitro test may not correspond to the actual behavior of products tested in vivo, since they are not exposed to the same conditions of the oral cavity 42 .…”

Section: Resultsmentioning

confidence: 93%

“…For the nystatin and chlorhexidine, the CIMs were 0.0156 mg/mL. For the evaluation of the antimicrobial potential of the extract of S. officinalis species were used of bacteria and yeasts, which are usually associated with the development of caries and oral candidosis, the antimicrobial potential of S. officinalis was evaluated before some species of bacteria and yeasts, with positive results mainly on Staphylococcus aureus, Enterococcus faecalis, Escherichia coli , Streptococcus mutans and Candida albicans 11,[18][19][20][25][26][27] . Thus, the results of this study corroborate the literature to demonstrate the antimicrobial effect on wide variety of microorganisms.…”

Section: Resultsmentioning

confidence: 99%

In vitro Evaluation of the Antimicrobial Potential of Salvia officinalis L. against Oral Pathogens

et al. 2019

View full text Add to dashboard Cite

The emergence of multidrug-resistant strains to antibiotics has motivated the search for new substances with antimicrobial activity, especially those derived from medicinal plants. Salvia officinalis L. is a medicinal plant that arouses scientific interest due to being associated with multiple therapeutic effects. The purpose of this study was to evaluate the in vitro antimicrobial potential of S. officinalis L. against pathogens in the oral cavity. The antimicrobial potential of the ethanol extract of leaf of S. officinalis L was evaluated by broth microdilution, with determination of minimum inhibitory concentration (MIC) and Minimum bactericidal/Fungicide concentration (MBC / MFC), against the species Streptococcus mutans, Streptococcus mitis, Streptococcus oralis, Streptococcus salivarius, Streptococcus sanguis, Candida albicans, Candida glabrata, Candida guillermond, Candida krusei and Candida tropicalis. The extract showed moderate antifungal potential before Candida species (MIC = 1 mg/mL). And for the species of Streptococcus, the antimicrobial activity was from moderate to strong whose MIC ranged from 0.25 to 1 mg/mL. In this study, the extract from the leaves of S. officinalis L. presented oral cavity antimicrobial activity against pathogens. These results point to S. officinalis as a possible source of active ingredients in the development of formulations with antimicrobial activity of dental use.

show abstract

“…Aqueous (70%) and ethanolic (50%) extracts of Salvia officinalis reduced acid production and inhibited adherence of Streptococcus mutans to teeth at a similar level as chlorhexidine (0.2%) (Al-Lamy & Al-Mizraqchi 2012). Salvia officinalis oil inhibited Candida albicans growth and cell adhesion to dentures (Sookto et al 2013). Hydroalcoholic extract of Salvia officinalis and Mentha longifolia inhibited growth of Streptococcus mutans, Lactobacillus rhamnosus and Actinomyces viscosus, which are responsible for tooth decay (Kermanshah et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Essential oils and plant extracts with activity against oral microorganisms: prevention and treatment of oral diseases

Herman

Młynarczyk

2015

Israel J Plant Sci

View full text Add to dashboard Cite

The aim of this study was to compare the antimicrobial activity of essential oils and extracts of Salvia officinalis, Thymus vulgaris, Mentha piperita, Juniperus communis and Rosmarinus officinalis with antibiotics against physiological and pathological strains of microorganisms isolated from the oral cavity. The antibacterial and antifungal activities of essential oils, extracts and antibiotics were evaluated using the disc diffusion method. Essential oils exhibited higher inhibitory activity against physiological microflora and all tested pathogenic microorganism strains than those observed for antibiotics and plant extracts. Essential oils and ethanolic extracts of Thymus vulgaris were the most potent growth inhibitor of all microorganisms isolated from the oral cavity. Depending on the bacterial strain tested, Thymus vulgaris oil had 3–8 times higher inhibitory activity compared with all tested antibiotics and exhibited the same strength of antifungal activity as amfotericin and miconazol against Candida albicans. Essential oils and extracts may be useful in the prevention and treatment of oral diseases caused by oral microorganisms.

show abstract

In vitro effects of Salvia officinalis L. essential oil on Candida albicans

Cited by 59 publications

References 16 publications

Antifungal activity of linalool in cases of Candida spp. isolated from individuals with oral candidiasis

Antifungal activity of linalool in cases of Candida spp. isolated from individuals with oral candidiasis

In vitro Evaluation of the Antimicrobial Potential of Salvia officinalis L. against Oral Pathogens

Essential oils and plant extracts with activity against oral microorganisms: prevention and treatment of oral diseases

Contact Info

Product

Resources

About