The silkworm, (B. mori L). is highly susceptible to pathogens such as protozoa, virus, bacteria and fungus. To evaluate the various bed disinfectant viz, Vijetha, Sericilin, Labex, and Amla compare with untreated control for their suitability and standardization for the management of diseases during silkworm rearing. The rearing of silkworm multivoltine hybrid race [NISTARI × (SK6×SK7)] was carried out in the centre. In the present study the larvae treated with Labex @ 5 g/sq. ft. ½ an hour before resuming feeding had shortest (20.00 days) larval duration. Larvae weight higher (31.24 g) respectively at late 5th instar stage. Larval mortality was observed (25.93%) Effective rate of rearing (64.08%) and significantly lowest disease incidence (26.06%) was recorded.