2007
DOI: 10.1016/j.ijantimicag.2007.05.003
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In vitro efficacy of imipenem in combination with six antimicrobial agents against Mycobacterium abscessus

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Cited by 33 publications
(27 citation statements)
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“…That both drugs had a positive impact in terms of embryo survival was correlated to a significant reduction in the number of CFU and abscesses, demonstrating a proof of concept that ZF embryos are suitable for drug efficacy testing. Since in vitro studies demonstrated decreased MICs in the presence of imipenem, for clarithromycin, minocycline, levofloxacin, and moxifloxacin (38), future work should also address the in vivo efficacy of these drug combinations using the M. abscessus/ZF couple.…”
Section: Discussionmentioning
confidence: 99%
“…That both drugs had a positive impact in terms of embryo survival was correlated to a significant reduction in the number of CFU and abscesses, demonstrating a proof of concept that ZF embryos are suitable for drug efficacy testing. Since in vitro studies demonstrated decreased MICs in the presence of imipenem, for clarithromycin, minocycline, levofloxacin, and moxifloxacin (38), future work should also address the in vivo efficacy of these drug combinations using the M. abscessus/ZF couple.…”
Section: Discussionmentioning
confidence: 99%
“…1Y3 Of all the RGM, M. abscessus is the most difficult to eradicate because the only consistently effective oral agents are macrolides and certain antituberculous agents. 2 levofloxacin. 2 Imipenem combined with moxifloxacin has also showed some additive benefit.…”
Section: Discussionmentioning
confidence: 99%
“…2 levofloxacin. 2 Imipenem combined with moxifloxacin has also showed some additive benefit. 2 Mycobacterium abscessus is found throughout the environment in soil, dust, rocks, bioaerosols, and water.…”
Section: Discussionmentioning
confidence: 99%
“…Notably, the in vitro susceptibilities for MXF against M. abscessus varied with the isolation source as well as between countries and patients infected with the same strain. A previous study conducted using 21 strains of M. abscessus in Japan found that the MIC of MXF ranged from 2 to 32 g/ml with an MIC 90 of 32 g/ml (35). Similarly, a study conducted in Taiwan with 98 M. abscessus clinical isolates reported an MIC range of 0.064 to 32 g/ml, also with an MIC 90 of 32 g/ml (22).…”
Section: Discussionmentioning
confidence: 90%