In vitro enzyme inhibitory properties, antioxidant activities, and phytochemical fingerprints of five Moroccan seaweeds

Grina, Fatiha; Ullah, Zafar; Kaplaner, Erhan; Moujahid, Abderrahman; Eddoha, Rabiaa; Nasser, Boubker; Terzioğlu, Pınar; Yılmaz, Mustafa Abdullah; Ertaş, Abdülselam; Essamadi, Abdelkhalid

doi:10.1016/j.sajb.2019.10.021

Cited by 46 publications

(38 citation statements)

References 74 publications

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“…This finding would mean that the strong antioxidant property of the seaweed extract is caused by polyphenols present in U. prolifera. This correlation is similar to those observed from previous studies from other seaweeds such as Fucus spiralis, S. vulgare, Cystoseira stricta, and Chaetomorpha crasssa on the relationship of phenolic concentration and their antioxidant activities (Grina et al, 2020;Arguelles et al, 2019;Gazali et al, 2019). The significant correlation between antioxidant activity and phenolic concentration suggests that U. prolifera extracts can cause oxidation inhibition via metal chelation and free radical scavenging mechanisms.…”

Section: Correlation Analysissupporting

confidence: 90%

“…Seaweeds' antioxidant activity may be associated with polyphenols such as phloroglucinol, vanillic acids, quinin acids, phenylethanol and dieckol in the U. prolifera extract. These active substances are known to have scavenging free radical ability (Grina et al, 2020;Mekiniae et al, 2019). Also, other biotic and abiotic factors such as strains of the alga and seasonal variation have a significant effect on the synthesis of phenolic compounds and thus affecting the antioxidant properties of the seaweed (Mekiniae et al, 2019;Yuan et al, 2018;Liu et al, 2018).…”

Section: 2-diphenyl-1-picrylhydrazyl (Dpph) Radical Scavenging Activitymentioning

confidence: 99%

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Nutrient Composition, Antioxidant and Antibacterial Activities of Ulva prolifera O. F. Müller

Arguelles

Sapin

2021

Squalen Bull. Marine Fisheries Postharvest Biotech.

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Seaweeds are marine organisms capable of producing diverse kinds of chemical compounds with promising pharmacological use. The study evaluated the proximate and elemental composition and the potential antioxidant (using CUPRAC, ABTS+, and DPPH assays) and antibacterial activities (using microtiter plate dilution assay) of Ulva prolifera O. F. Müller. The seaweed has a total phenolic content of 829 ± 2.00 mg GAE/g. Antioxidant efficiency of U. prolifera exerted high ability of reducing copper ions, potent ABTS+ and DPPH scavenging activities in a concentration-dependent manner with IC50 value of 24.7 mg GAE/mL, 43.52 mg GAE/mL, and 54.1 mg GAE/mL, respectively, more effective than ascorbic acid. In vitro antibacterial activity assay showed that U. prolifera exhibited inhibitory activity against bacterial pathogens such as Methicillin-resistant Staphylococcus aureus (MIC = 125 mg/mL), S. epidermidis (MIC = 125 mg/mL), and Pseudomonas fluorescens (MIC = 500 mg/mL). This investigation is the first documented report regarding antibacterial activity of U. prolifera against P. fluorescens. In addition, results showed elemental composition to be in decreasing order of Ca K Mg Na Mn Fe Zn Cu Pb Cd Cr. Proximate composition of U. prolifera showed high carbohydrate and protein content with a percentage composition of 36.20 ± 0.27% and 23.72 ± 0.31% (dry weight), respectively. This study is the first report in the Philippines that shows the potential of U. prolifera as an excellent candidate organism as source of chemical compounds with relevant application to the pharmacological industry.

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Section: Correlation Analysissupporting

confidence: 90%

Section: 2-diphenyl-1-picrylhydrazyl (Dpph) Radical Scavenging Activitymentioning

confidence: 99%

Nutrient Composition, Antioxidant and Antibacterial Activities of Ulva prolifera O. F. Müller

Arguelles

Sapin

2021

Squalen Bull. Marine Fisheries Postharvest Biotech.

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“…For instance, Metidji et al [ 29 ] reported a phenolic content ranging from 3.49 to 101.05 mg GAE/g dried extract and a lower content of flavonoids (ranging from 0.85 to 5.63 mg QE/g dried extract) using different mixtures of organic solvents like chloroform, methanol, diethyl ether or n-butanol. In another study, Grina et al [ 10 ] described the phenolic and flavonoid contents of Gelidium sesquipedale extracts, but using higher temperatures than in the present study. Using the classical solvent extraction method with 70% ethanol at 60 °C for 2 h, the authors described a phenolic content of 11.1 ± 0.03 µg pyrocatechol equivalents (PE)/mg extract and a flavonoid content of 5.84 ± 0.02 µg QE/mg extract.…”

Section: Resultsmentioning

confidence: 57%

“…The authors showed a FRAP value of 16.1 ± 1.1 mg of gallic acid equivalent/g dry extract. In a similar study, Grina et al [ 10 ] described the antioxidant activity of five seaweed species collected from the Moroccan Atlantic Ocean. The aqueous ethanolic extract (70% ethanol) of Gelidium sesquipedale produced by the traditional solvent extraction at 60 °C for 2 h were used to evaluate the antioxidant capacity with different methods: DPPH assay (IC 50 = 84.61 ± 3.9 mg/mL), β-carotene-linoleic acid assay (IC 50 = 75.36 ± 3.6 mg/mL), ABTS assay (IC 50 = 44.46 ± 2.4 mg/mL) and FRAP (IC 50 = 83.73 ± 2.9 mg/mL).…”

Section: Resultsmentioning

confidence: 99%

“…There are signs in the literature of the effective nutritional value and biological activities from Gelidium sesquipedale extracts, such as anti-enzymatic, antimicrobial, antioxidant, anti-inflammatory, or cytotoxic activities [ 9 , 10 , 11 ]. Moreover, the fatty acid composition, the total phenolic (TPC) and total flavonoid (TFC) contents, the identification of functional low-molecular-weight carbohydrates, the recovery of proteins and the detection of mycosporine-like amino acids (MAAs) have been reported in the literature [ 12 , 13 , 14 , 15 , 16 ], showing the potential of Gelidium sesquipedale biomass.…”

Section: Introductionmentioning

confidence: 99%

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Valorization of the Red Algae Gelidium sesquipedale by Extracting a Broad Spectrum of Minor Compounds Using Green Approaches

et al. 2021

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Until now, the red algae Gelidium sesquipedale has been primarily exploited for agar production, leaving an undervalued biomass. In this work, the use of eco-friendly approaches employing ultrasound-assisted extraction (UAE) and green solvents was investigated to valorize the algal minor compounds. The green methods used herein showed an attractive alternative to efficiently extract a broad spectrum of bioactive compounds in short extraction times (15 to 30 min vs. 8 h of the conventional method). Using the best UAE conditions, red seaweed extracts were characterized in terms of total phenolics (189.3 ± 11.7 mg GAE/100 g dw), flavonoids (310.7 ± 9.7 mg QE/100 g dw), mycosporine-like amino acids (MAAs) (Σ MAAs = 1271 mg/100 g dw), and phycobiliproteins (72.4 ± 0.5 mg/100 g dw). Additionally, produced algal extracts exhibited interesting antioxidant and anti-enzymatic activities for potential applications in medical and/or cosmetic products. Thus, this study provides the basis to reach a superior valorization of algal biomass by using alternative methods to extract biologically active compounds following eco-friendly approaches. Moreover, the strategies developed not only open new possibilities for the commercial use of Gelidium sesquipedale, but also for the valorization of different algae species since the techniques established can be easily adapted.

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Subcritical Water Extraction of Phenolic Compounds from Vaccinium Dunalianum Wight Leaves and Their Antioxidant and Tyrosinase Inhibitory Activities in Vitro

Yang

Wang

Jiang

et al. 2023

Chemistry & Biodiversity

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Subcritical water extraction was used to extract bioactive phenolic compounds from Vaccinium dunalianum Wight leaves. The optimal extraction conditions were determined as an extraction temperature of 150 °C, an extraction time of 40 min, and a liquid‐solid ratio of 35 : 1 mL/g. The total phenolic content reached 21.35 mg gallic acid /g, which was 16 % higher than that by hot water extraction. The subcritical water extraction extract exhibited strong scavenging activity of DPPH free radical and ABTS+ free radical, as well as significant tyrosinase inhibitory activity. The study suggests that subcritical water extraction can alter the composition of the extracts, leading to the production of various phenolic compounds, effective antioxidants, and tyrosinase inhibitors from Vaccinium dulciana Wight leaves. These findings confirm the potential of Vaccinium dunalianum Wight as a natural antioxidant molecule source for the medicine and food industries, and for the therapy of skin pigmentation disorders.

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In vitro enzyme inhibitory properties, antioxidant activities, and phytochemical fingerprints of five Moroccan seaweeds

Cited by 46 publications

References 74 publications

Nutrient Composition, Antioxidant and Antibacterial Activities of Ulva prolifera O. F. Müller

Nutrient Composition, Antioxidant and Antibacterial Activities of Ulva prolifera O. F. Müller

Valorization of the Red Algae Gelidium sesquipedale by Extracting a Broad Spectrum of Minor Compounds Using Green Approaches

Subcritical Water Extraction of Phenolic Compounds from Vaccinium Dunalianum Wight Leaves and Their Antioxidant and Tyrosinase Inhibitory Activities in Vitro

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