This study focuses on evaluating the concentration dependent antimicrobial efficacy of herbal dentifrice (tooth paste) in comparison with a conventional non dentifrice. One non -herbal dentifrice and three herbal dentifrices were selected for this study. Saliva samples were collected from 10 healthy individuals. All toothpaste samples were diluted in saline in 25%, 50% and 100% concentrations. Their antimicrobial activity was determined by modified agar well diffusion method. Five wells were cut at equidistance in each of the nutrient agar plates. The plates were seeded with saliva sample. Dentifrice dilutions were introduced into the wells. The plates were incubated overnight and the diameter of zones of inhibition was measured. The antimicrobial efficacy was similar in herbal and non-herbal dentifrices and also in their different concentrations. We can advocate herbal dentifrices, as there is a sudden surge in the concern over using chemical and non-herbal products. Thus, comparable properties with standard pastes makes herbal pastes a viable option for plaque control.